3BM1


Conserved Protein Domain Family
YdjA-like

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cd02135: YdjA-like 
nitroreductase family protein similar to Escherichia coli YdjA
A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase YdjA from Escherichia coli. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. Members of this family are also called NADH dehydrogenase, oxygen-insensitive NAD(P)H nitrogenase or dihydropteridine reductase.
Statistics
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PSSM-Id: 380312
Aligned: 79 rows
Threshold Bit Score: 127.72
Created: 13-Jan-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
FMN bindinghomodimer
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:FMN binding site [chemical binding site]
Evidence:
  • Structure:3BM1: Escherichia coli nitroreductase YdjA dimer binds two molecules of FMN, contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1              ###                       # ###                                           
3BM1_A         4 LELLINRRSASRLAep-apTGEQLQNILRAGMRAPDHKSMQPWHFFVIegegrerfsavleqga----iaagsddkaidk 78  Escherichia col...
BAE05363       4 QEAIASRRSIKKFKhdmtiDDDKLYQAIEKAADAPNHGMREPWRIIHIakdrlgemsrdvthfa-----fpnhpekqedh 78  Staphylococcus ...
AGK53955      12 MDIIKTRRTIKKFKsd-giNRAVILSWLSAASMAPNHRMTEPWEIVFIgsetran-----------------------lh 67  Bacillus sp. 1N...
PCQ21445       4 KKAIKERRSVKNYDyemyiDEEKVFSLVDLATYAPNHGMREPWRLVYIhkkqipefaeevaes------afvndsakqek 77  Klebsiella pneu...
WP_125061653   2 NRRSVKKFKHDMTI-----DDNALYEAIEKATDAPNHGMREPWRVVHVakdrlgnmseditrf------afpdspekrad 70  Pseudomonas aer...
WP_016913132   4 KKAITERRSVKNYDyemyvDEEKVFSLVDLATYAPNHGMREPWRLVYIskkqipefaekvaes------afandsekqek 77  Staphylococcus ...
WP_068131115   4 IEPILNRKSTKIFKktepiSKEAVETIIEAAIQAPNHHITEPWKFIVMqgenmqqfydaamefqknrdiseeefermkvk 83  Nosocomiicoccus
AQL56654       4 KDAILNRRSIKIFGes-tiDVEVVKQAINSAIYAPNHGVREPWHIKYVqkeqleqyaeqvgdi------afkgdeqkkrn 76  Auricoccus indicus
GBU10390       4 TSVMKERRTIRTFTgn--iPDKDLLALLGSASYAPNHRMREPWSFILVnsigdweklytlttk-------rppylaqlak 74  Erysipelotricha...
STO09137       8 QQLIESRRTIRMFTeg-alDTAELYELLTSAHQAPFHNKVEPWNVYLFngdgkdvlldalepa------fadgaeakrek 80  Exiguobacterium...
Feature 1                                    #  ##                   #####                       
3BM1_A        79 arnaPFRAPLIITVVAkceen-hkvprWEQEMSAGCAVMAMQMAAvAQGFGGIWRSGAltesPVVREAFGCreQDKIVGF 157 Escherichia col...
BAE05363      79 ynnvTNLGGMLVLVLKtdpr---qrqnRENFFAMGAYAQNLMLLLhEQGIGTCWKTPPyifePKVRKVFGVhgDEVIAGF 155 Staphylococcus ...
AGK53955      68 hktnFGNAPTVFAIISqrgkn--everEENRSATSCFIQNFMLAAwAEGVGTFWSSIGi--tPKNRTLLNVpdDYDVIGV 143 Bacillus sp. 1N...
PCQ21445      78 yinkVTKVGGMFVILSkrdsr--qkenLENQMAIGAFVQNLMLLMhDEGMGSCWKTPAfifnPSFRKTVGAhdDEDVCGF 155 Klebsiella pneu...
WP_125061653  71 hydkVTKLGGMLLLIMkadpr--qrqnRENYFAFGAFAQNLMLLLyEAGIGTCWKSPAyifePKIRKALNIedDEILAGF 148 Pseudomonas aer...
WP_016913132  78 yinkVTKVGGMFVILSkrdpr--qkenLENQMAVGAFVQNLMLLMhDEGMGSCWKTPEfifrPTFRKIVGVndDEEVNGF 155 Staphylococcus ...
WP_068131115  84 mvskTMVAPTVILAVYsknknktrgkyEEDILAVGAAIQNMLIQAtSMGIDSIWKTGPvynaTEVKSALGIeeDEEVVGA 163 Nosocomiicoccus
AQL56654      77 haskLSMLGGILVVSVdrdvr--qkqhHENLMAGGAFMQNLMLLLhAEAVGTCWHTPGymftPEYYQMMNVssDQEIIAE 154 Auricoccus indicus
GBU10390      75 qlenDGTYPTGIIVICpvnad--pkvaREDLLATAAFIQNFQLAAwADKYGVVWRTTCi--dADFEQSIGIkaNEIVVGF 150 Erysipelotricha...
STO09137      81 iagrIRNAAACIYVTTkpfet--ekdkKDALLATATFIQNFHLLCsERDIGLVWRTGGifedARLQDMIGAe-GETFVGL 157 Exiguobacterium...
Feature 1             
3BM1_A       158 LYLGT 162 Escherichia coli K-12
BAE05363     156 LYLTD 160 Staphylococcus haemolyticus JCSC1435
AGK53955     144 LAVGY 148 Bacillus sp. 1NLA3E
PCQ21445     156 LYLTE 160 Klebsiella pneumoniae
WP_125061653 149 LYLTD 153 Pseudomonas aeruginosa
WP_016913132 156 LYITE 160 Staphylococcus vitulinus
WP_068131115 164 IFFGE 168 Nosocomiicoccus
AQL56654     155 LYLMD 159 Auricoccus indicus
GBU10390     151 LQAGT 155 Erysipelotrichaceae bacterium
STO09137     158 LQLGR 162 Exiguobacterium aurantiacum

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