4QBL,4QBN


Conserved Protein Domain Family
VRR-NUC-like
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cd22365: VRR-NUC-like 
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Virus-type replication repair nuclease
This model characterizes a set of nucleases that resemble Holliday-junction resolving enzymes. They belong to a superfamily of nucleases including very short patch repair (Vsr) endonucleases, archaeal Holliday junction resolvases, MutH methyl-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and FokI.
Links
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Statistics
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PSSM-Id: 411769
Aligned: 6 rows
Threshold Bit Score: 112.934
Created: 27-Jul-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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active site
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1: active site [active site], 5 residue positions
Conserved feature residue pattern:E Q D E KClick to see conserved feature residue pattern help
Evidence:
  • Structure:4QBL: Psychrobacter sp. VRR-NUC DNA repair nuclease active site binds a divalent cation; contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #   #                                                          #              
4QBL_A         5 LTEDEVQTVVXNWSKRQkfkgrplfdYIHHSPNGgkraakigssgkryspeaakfkrxgvkaGYPDLIIDIArg------ 78  Psychrobacter s...
4QBN_A         2 TKEGRVQKYAKERFEALg-------gLVRKLSYEgr-------------------------sGAPDLLVILPr------- 42  Salmonella phag...
WP_137500312   3 TPEGRVQKYAKERFEAIg-------gLVRKLSYEgr-------------------------sGAPDLLVILPg------- 43  Escherichia coli
YP_009004669   2 TPEGKVQAHLQRRFKAIg-------gLVRKISYEgr-------------------------rGCPDLFIVLPg------- 42  Edwardsiella ph...
QBQ80489       2 TPEGKIQSHLKRRVKEVg-------gFCRKLAWEgr-------------------------aGAPDLIIIIN-------- 41  Escherichia pha...
ATE85589       4 TPEGEIVEYIKKQLKARg-------cLIRKIGYEmr-------------------------rGCPDLLVLAPqyfihsse 51  Salmonella phag...

Feature 1                        # #                                          
4QBL_A        79 ---------aYHGLRIEIKKDgNSYATPAQKERIEXLAKEGYCAVVAKGIDNVISVIQQYI 130 Psychrobacter sp. PRwf-1
4QBN_A        43 ----------GVIWFVEVKKDeNTKPDPHQLREHERFRKRGANVFVVGSFKQVDKLIEHYY 93  Salmonella phage SETP3
WP_137500312  44 ----------GIVLFVEVKKDeNTKPDPHQLREHERMRKRGANVFVVGSFKQVDDLIANYY 94  Escherichia coli
YP_009004669  43 ----------GVVVMVEVKKP-GGTPEPHQVREIERLRQRGVPVYVIDSIEGADKLVAFYS 92  Edwardsiella phage eiAU-183
QBQ80489      42 ----------GKIVFVEVKRP-GGKPKPHQVREHERMARRGADVRVIDNISDCDLLVAELV 91  Escherichia phage vB_EcoS_PTXU06
ATE85589      52 ssdgcpfyreSCVIFVEVKKSeDTQPEEHQLREHARMRAVGADVRVIGSKRQVDALVKELF 112 Salmonella phage St162

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