4Y60,3F27


Conserved Protein Domain Family
HMG-box_SoxF
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cd22032: HMG-box_SoxF 
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high mobility group (HMG)-box found in group F SRY-related high-mobility group (HMG) box (Sox) transcription factors
SoxF transcription factors includes three members: Sox7, Sox17, and Sox18. They regulate endothelial cell fate as well as development and differentiation of the developing heart, blood cells, and lymphatic vessels.
Links
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Statistics
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PSSM-Id: 438841
Aligned: 19 rows
Threshold Bit Score: 133.31
Created: 8-Apr-2019
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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DNA binding
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Structure:3F27; Mus musculus SOX-17 binds DNA, contacts at 4A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1       ## ## ##   #  #          ###  ##  #  #                             ## ### 
4Y60_C      3 RIRRPMNAFMVWAKDERKRLAQQNPdlHNAVLSKMLGKAWKELNtaEKRPFVEEAERLRVQHLRDHPNYKYRPRRK 78  house mouse
Q9BT81     44 RIRRPMNAFMVWAKDERKRLAVQNPdlHNAELSKMLGKSWKALTlsQKRPYVDEAERLRLQHMQDYPNYKYRPRRK 119 human
RUS75129   90 KIPRPMNAFMVWAKDERKKLAIENPeiHNAELSKILGRKWRSLKpdEKKPFVDEAERIRVKHTFDHPHYKYKPRRR 165 eastern emerald elysia
3F27_D      6 RIRRPMNAFMVWAKDERKRLAQQNPdlHNAELSKMLGKSWKALTlaEKRPFVEEAERLRVQHMQDHPNYKYRPRRR 81  house mouse
Q8AWH2     57 RIRRPMNAFMVWAKDERKRLAQQNPdlHNAELSKMLGKSWKSLTlaSKRPFVEEAERLRVQHIQDYPDYKYRPRRK 132 tropical clawed frog
Q6F2F0     57 RIRRPMNAFMVWAKDERKRLAQQNPdlHNAELSKMLGKSWKSLTlaSKRPFVEEAERLRVQHIQDYPDYKYRPRRK 132 tropical clawed frog
Q6GLH8     57 RIRRPMNAFMVWAKDERKRLAQQNPdlHNAELSKMLGKSWKSLTlaSKRPFVKEAERLRVQHIQDYPDYKYRPRRK 132 tropical clawed frog
CAD58843  179 RIRRPMNAFMCWAKTERKRMAAAFPdhHNAELSKMLGKKWKEMSneDKRPYITEAEKLRMKHMQEHPDYKYRPRRK 254 vase tunicate
KHN87542   61 RVRRPMNAFMVWARKMRRKLATENPgmHNADLSKILGRRWKGMShvEKQPFVQQAEAIRVQHLNDNPNYKYRPKRK 136 dog roundworm
ABA02366   72 RIKRPMNAFMVWAQVERRRLADANPelHNAELSKMLGLTWRALNstQKRPFVDEAERLRLQHMQDYPNYKYRPRRR 147 starlet sea anemone

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