Conserved Protein Domain Family
CLSTN_C

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pfam19699: CLSTN_C 
Calsyntenin C-terminal
This is the cytoplasmic C-terminal domain of clasyntenin (CLSTN) proteins 1, 2 and 3 (also known as Alcadein-alpha, gamma and beta). These are postsynaptic Ca2-binding proteins, evolutionarily conserved type I membrane proteins. CLSTN forms a complex with APP and X11-like that stabilizes both APP and CLSTN proteins metabolically. CLSTN strongly associates with kinesin-1 light chains (KLC1) that induce kinesin-1 association with vesicles and functions as a novel cargo in axonal anterograde transport. This domain includes the WD motifs required for KLC1 interaction (although one WD motif is sufficient), and the NP motif.
Statistics
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PSSM-Id: 466150
Aligned: 8 rows
Threshold Bit Score: 565.163
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
KPP66417      527 DLQLPKEIGRSIRAQFNPSQSSLTLK--SDGTVNLNGAMQHISYLNSRQFPTPGIRQLRISTTVKCISEDSCVFVPDAEM 604 
XP_017951391  601 ELHTVDGIGEAVKINLNTSRSDVTLE--GNEIDKCDQAMQQVSYVNSRQFPTPGMRRFTITTSVRCFNEETCITIPDVEG 678 
XP_016050428  500 DLQVPEDSGHSVKIQADPSQSALTLE--GEDIGELEKAMQHLSYLNSRQFPTPGIRRLKITSTVKCFNEAACISAPPLDS 577 
5_pfamImport    1 DLPALPNASSAVKVHFNPTRLTLTLEveGHDLEQLTEAVKRVAYVNTRQFPTPGPRDLHLATVLHCVEEG-CPDVPEVSA 79  
XP_683286     560 DFGDLETLGSGMKVHVNPSQSVLVLE--GDDIESFNRAVQQVTYRNSLRFATPGVRPLKLTTSLRCFSEESCLSLRQLEG 637  zebrafish
XP_020365698  574 DLLDSGNSYKGVMVHFNPTQSVLSME--GDDIESFDKNMQHVSYLNSRQFPTPGIRRLKISTTVKCFNEETCITIPDVEG 651  whale shark
XP_017202086  598 ELQLPEDSGRGVQIQANPGQSVLTVA--GDDVGELEKALQHVSYVNSRQFPTPGVRRLTLTSSVKCFNEAACISLPPVDG 675  rabbit
XP_015149404  607 DYSDFDSLGKGMKVHVNPSQSLLTLE--GDDVETFNHAIQHVAYMNSLRFATPGVRPLRLTTNVKCFSEESCVSIPDVEG 684  chicken
KPP66417      605 YLMVLQPEEPKISLSGI-DHFARSAAEFESDEGVTLFPELRIVSTITREVDVEVEAEgtddpTVQESMLSEEIMHNLDRC 683 
XP_017951391  679 YIIVLQPEEPRISIKGI-DHFARSASEFESNGGVPLFPELHIISTITREIESDGEDP-----TVQESLVSEEIVHDLDTC 752 
XP_016050428  578 CVVVLQPEEPRISLSGI-HHFARAASEFESAEGVFLFPELRAISTVTRAVGPEGDGDed--pTVQESLVSEEVVHDLDSC 654 
5_pfamImport   80 YVMVLQPEDPHIVLSGA-DSFARPAGEF--PDGVVLFPDLRVVSSVTREVPSDVRSS-----PGQEAVVSEEILHNLDRC 151 
XP_683286     638 YLVVLQPDAPQISLSGVgPHLARPAAEFEGPQGVPLFPELRIVCSLSHAVNTAAQGM------EGGALMSDAVAHTLDGC 711  zebrafish
XP_020365698  652 YVMVLQPDEPKISLSGI-DHFARAASEFESNEGVPLFPELKIVSTITREVESEAEDEde--pTVQESMISEEIMHNLDMC 728  whale shark
XP_017202086  676 YVMVLQPEEPKISLSGV-HHFARAASEFESAEGVSLFPELRIVSTITREVEPEGDGAed--pTVQESLVSEEIVHDLDTC 752  rabbit
XP_015149404  685 YVVVLQPDAPQILLSGT-AHFAHPASDFEAPDGVPLFPNLQITCSISHQVEAKKDENwh--gTVTDTRMSDEIVHNLDGC 761  chicken
KPP66417      684 EVTVIDEELDSEHESLEVDMGLVHQYNLQISSSTLGMVITGVNTMASYEQVLHLIRYKNWHTEALFERKFKLVCSELSAR 763 
XP_017951391  753 EVVVMGEELNPGEESLQLDVTHLQQTRIEISSSNYGISLTGIDSMENYEELLHLIRYRNWNTVSLFDRKFKLICSELNGR 832 
XP_016050428  655 EVTVEGEELNPEQESLEVDMARLQQKGIEVSSSHLGMTLTGVGTMASYEEALHLLRYRNWHTRSLLDRKFKLTCSELNGR 734 
5_pfamImport  152 EVAALGDPLEGPQERFEVPADQLSPQGLEVTSGPQGITISGVESLASYERVLRTVRYLHNNPDSLFERRFRLTCSELNGR 231 
XP_683286     712 EVQPLGEELNTEREELLVDMESLRERGLDIINTTAYIAITGAESISVYEDVLRSIHYRLAKGSARFERRFRLSCSEMNGR 791  zebrafish
XP_020365698  729 EVSVLGDELNAEQESFEVDPSQLQQRGMEMSNSSTGLTITGVNTMANYEEMLHSIRYRNWNSESLFERKFKIVCSELNGR 808  whale shark
XP_017202086  753 EVTVEGEELNPEQESLEVDVARLQQKGIEVSHSDLGVVFTGVDAMASYEEVLHLLRYRNWHTRSLLDRKFKLICSELNGR 832  rabbit
XP_015149404  762 EISLVGDDLDSEREYLLLDGALLQQRGLELVNTSAYLTITGVESIAVYEEILRQVSYHINRGAALYERKFHLSCTEMNGR 841  chicken
KPP66417      764 YVSNHFKVEVSVIHTANPAEHAN--AMVQPQFISPVQHASMDLPGHNLVNAHQASVVPSAATIVIVVCVSFLVFMIIVGV 841 
XP_017951391  833 YISNEFHVEVNVIHTASHVEVPNh-IMAQPQFVHPMHPLFGDLTGHNIANPHASSVVPSAATIVIVVCVSFLVFMIILGV 911 
XP_016050428  735 YVSNEFQVEVNVLHTARPVEHASh-MAAQPQFVHPEHRAFVDLSGHNLASPHPFAVVPSTATVVIVVCVSFLVFMIILGV 813 
5_pfamImport  232 YASNSLPLDVTVLHVVRASEHVNh-ARVQPEFVHSVH--YPELSGHSLTATAHSNAIPGTATVVIVLCVGFLVFAIVLGV 308 
XP_683286     792 YTSNELTLEVNFLHSLDSLYHPShlLASQQQFLHPSHHTG-ELSGHTLPNPHRNSVVPGAATVIIMVCVGFLVVMVILGV 870  zebrafish
XP_020365698  809 YASNEFKVEVNVIHTANPVEYPNh-LLAQPEFVRPVQHASVDLSGHNLANPHSSSVVPSAATVVIVVCVSFLVFMIILGI 887  whale shark
XP_017202086  833 YMSNEFKVEVNVIHTASPVEHASh-MAAQPQFVHPEHRSFVDLSGHNLANPHPFAVVPSTATVVIVVCVSFLVFMIILGV 911  rabbit
XP_015149404  842 YSSNEFSVEMNVLHNMNQAAHPNh-MLNSQQFIHRGHHLPPELSGHSLASTHNSPMVPSAATIIIVVCVGFLALLVILGI 920  chicken
KPP66417      842 FRIRSAHQNAMRDQ-----------ENCKENEMDWDDSALTITVNPMETYE 881 
XP_017951391  912 FRIRVTHQRALRDQ-----------EGGKENEMDWDDSALTITVNPMETYE 951 
XP_016050428  814 FRIRAAHQRTMRDH-----------DSGKENEMDWDDSALTITVNPMETYE 853 
5_pfamImport  309 VRARSANQRGAREQ-----------EGSRDNEMDWDDSALTITVNPMEEEE 348 
XP_683286     871 FRIRSIHRRGEGAR-----------GGGKEGGNQWDDSALTIIVNPMETYE 910  zebrafish
XP_020365698  888 FRIRAAHQRTMRDQ-----------ENGKENEMDWDDSALTITVNPMETYE 927  whale shark
XP_017202086  912 FRIRAAHQRTMRDQ-----------DAGKENEMDWDDSALTITVNPMETYE 951  rabbit
XP_015149404  921 LRIHSLHRQGMGQEvpgaaaeghtgTGSKDGDLFWDDSALTIIVNPMESYQ 971  chicken
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