Conserved Protein Domain Family
IspG

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COG0821: IspG 
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG/GcpE [Lipid transport and metabolism]
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG/GcpE is part of the Pathway/BioSystem: Isoprenoid biosynthesis
Statistics
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PSSM-Id: 440583
Aligned: 411 rows
Threshold Bit Score: 400.186
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_011001165  17 LPRRHSRAAEIrwgeRLVRVGGDAPVCVQSMTNTDTADAIGTAIQVKELARTGSELVRITVNTPEAAAAVPAIREQLdrm 96 
WP_012911045   3 IQRNPTRSVRI----GSCTIGSGHPIAVQSMTATHTQDIDGTVALVNDLYENGADVVRIAVDSKKDAEALAEIRKQT--- 75 
WP_013108888   3 LRRNPTRAVRV----GSCTIGGGHPIAVQSMTATHTQDIDATVAQVLDLEKAGADVIRIAVDSPKDAAALKEIRSQV--- 75 
WP_041399500   3 ITRNPTREVRI----GSIAIGAGNPIAVQSMTATKTQNVDATVAQIQHLLEANADVIRVAVDSKKDAAALKEIAAQT--- 75 
NP_864753      7 IRRNPTRPVTI----GSITIGDGHPIAVQSMTATKTQNIDATVEQAEALHARGAGVVRIAVDSDKDAEALAEIRKQT--- 79 
WP_075097023   6 IARNPTRSVRI----GSVTIGGGNPIAVQSMTATHTQNIEATVGQIRDLVEAGADVIRVAVDSRKDADALREVAQRI--- 78 
WP_068804025   3 IARYPTRPVRI----GRITIGADHPVAVQSMCATKTQDVAATVAQANDLVAAGAGVVRIAVDTPKDADALPAIRAQT--- 75 
WP_077026537   3 IQRNPTRRVKI----GSVAIGDGCPIAVQSMTATRTTDIDATVAQINDLVNAGADIVRVAIDSQKDAEALIEVRSQV--- 75 
WP_096460564   5 LPRNPTRAVRI----GSVTIGAGHPIAVQSMCATRTQDIEATVGQVQALAAAGADVIRIAVDNRKDAAALASIRSQT--- 77 
WP_096527063   3 LPRNPTRPVSI----GNITIGNGNPIAVQSMCATHTQDIVATVKQVNDLVEAGADIIRIAVDTKRDVEALADIRQQT--- 75 
WP_011001165  97 giDVPLVGDFHYNGHKLLQDHPacaeALSKYRINPGNVGQga---krDTQFAQMIETACRYGKPVRIGVNWGSLDQDLLA 173
WP_012911045  76 --KANLSVDLQENYRLAELVAP----HVDKVRYNPGHLYHhethkpwQEKVRYLAQVAIDNDCAMRVGVNCGSVDPAKKE 149
WP_013108888  76 --KANLSVDLQENYRLAEQVAP----YVDKIRYNPGHLYHherskpwQEKVAYIAQVAKDHDCALRVGVNCGSVDPAKKV 149
WP_041399500  76 --NANLSVDLQENYRLAELVAP----YVQKIRYNPGHLYHherekpwQEKVAYIVDVAKENDCAIRVGVNCGSVDPAKLD 149
NP_864753     80 --QANLAVDLQENFRLAEKVAP----HVDKIRYNPGHLYHhareltwQEKVRYLIDTAGSNNCAVRIGVNCGSVDPAKKE 153
WP_075097023  79 --EANLAVDLQENYRMAEVVAP----SIAKIRYNPGHLYHherekpwQDKVKYLVDVATEHDCAMRVGVNCGSVDPDKKE 152
WP_068804025  76 --EANLSIDLQENYRMAERVAP----HVDKIRYNPGHLYHhekhkpwQDKVRYLADIAARHDCALRVGVNAGSLDPARAA 149
WP_077026537  76 --SGNFSVDLQENYRLAEVIAP----YVDKLRYNPGHLYHherekpwEDKVRYIADVAKDNDCAIRVGVNCGSVDPDKKA 149
WP_096460564  78 --NANLSADLQENYRMAELVAP----HVDKLRYNPGHLYHherakpwQDKVRYLVDIAGGRGIALRVGVNCGSVDPAKAD 151
WP_096527063  76 --QANLSVDLQESYRLAKTVAP----HVDKIRYNPGHLYHhekqkpwQDKVKFLVDVAGENDCAIRVGVNGGSVDPSKTS 149
WP_011001165 174 RI-MDEnaqraapwdaravMIEALITSAIESARKAEEIGLpgSQIILSCKVSAVQDLIAVYRELARRC-DYALHLGLTEA 251
WP_012911045 150 MFdPHD-------------SITPMLESAKEHCDLLDSIGF--TRYNVSLKDSDPKKVVEVNKRFAEMRpDVPLHLGVTEA 214
WP_013108888 150 DDyGGD-------------ENGPLLASAFEHCEYLDSIGF--TRYVVSIKDSDPKNVIEVNKRFALQRpDIPLHLGVTEA 214
WP_041399500 150 KYdPED-------------SISPMLESAFDHCEYLDSLGF--TRYCVSLKDSDPQKVIEVNRRFAEKRpDVPLHLGVTEA 214
NP_864753    154 KYdHDD-------------SITPMLESALEHCELVDSLGF--HNFVVSLKDSDPSKVVQVNTLFAEKRpDVALHLGVTEA 218
WP_075097023 153 KFaADD-------------SIGPMLASAFEHCELLDSLGF--TRYAVSLKDSDPRNVIEVNRRFAEQRpDVPLHLGVTEA 217
WP_068804025 150 LFdAHD-------------SISPMLLSAAEHCELLDSIGF--TRYCVSLKDSDPAKVVELNKRFAAQRpDVPLHLGVTEA 214
WP_077026537 150 KYaADD-------------SISPMLESAWDHCRLLDDYGF--TRYCVSLKDSDPQKVIEVNKRFAEERpDVPLHLGVTEA 214
WP_096460564 152 KYaAND-------------KLSPMIESALEHCELLDRIGF--TNYCVSLKDSDPNQVIEVNTRFAAERpDVPLHLGVTEA 216
WP_096527063 150 KFaVDD-------------SISPMLASAFEHCELLDSLSF--TRYCVSLKDSDPSKVIEINKRFAADRpDIPLHLGVTEA 214
WP_011001165 252 GMGSKGIVASTAALSVLLQEGIGDTIRISLTPePgaprEKEVIVAQEILQTMGL-RNFT--------PMVIACPGCGRTT 322
WP_012911045 215 GLPPDGIIKTRIAFEQLIGRGIGDTIRVSLTV-PndrkKDEISAGRQILADIAAgRVRSvvdyglktLNIISCPSCSRVE 293
WP_013108888 215 GLPPDGIIKTRIAFEQLISQGIGDTIRVSLTV-PnnrkHEEIEAGRKILADIAAgRVRSfvdfgldtLNIISCPSCSRVE 293
WP_041399500 215 GMPPDGVIKTRIAFEQLIGKGIGDTIRVSLTV-PndrkREEIEAGRNILADIAAgRVRSvvnfdtsgLNIISCPSCSRVE 293
NP_864753    219 GMPPDGIIKTRIAFEQLIGKGIGDTVRVSLTL-PnprkPEEIDAGKQIVEDIHAgRVRSvvkfddskLNIISCPSCSRVE 297
WP_075097023 218 GMPPDGIIKTRIAFEQLISRGIGDTIRVSLTV-PnarkSEEIVAGRKILDDIAAgRVRSvvdyglnvLNIISCPSCSRVE 296
WP_068804025 215 GLPPDGIIKTRIAFEQLIGAGIGDTIRVSLTL-PnarkAEEVTAGQQILADIAAgRVRSvvdf-gkgLNIISCPSCSRVQ 292
WP_077026537 215 GMPPDGVIKTRIAFEQLISRGIGDTIRVSLTV-PnnrkHEEIEAGRSILDDIANgRVRSvvdyglktLNIISCPSCSRVE 293
WP_096460564 217 GLPPDGIVKTRVAFEQLISRGIGDTIRVSLTV-PnprkHEEIVVGRQILADIAAgRVRSvvrydnsgLNIISCPSCSRVE 295
WP_096527063 215 GMPPEGIIKTRIAFEQLISRGIGDTIRVSLTL-PlnqkGEEIKAGRQILADIAAgRVRSvvdyglksLNIISCPSCSRVE 293
WP_011001165 323 STVFQeLAARIQSYLREqMpvwKtqypgvEDMNVAVMGCIVNGPGESKHANIGISLPGtGEspaAPVFVDGVKVKTLRGE 402
WP_012911045 294 NQAFIeLAQQVKEMTRY-A---Eq-----HSLTIAVMGCRVNGPGETDDADLGLWCGP-NF---VNLKRGSTELGQYAYD 360
WP_013108888 294 NEAFIdLAQQVKEMTAY-A---Kd-----HKITIAVMGCRVNGPGETDDADLGLWCGP-NH---VNLKKGPVELGHFKYD 360
WP_041399500 294 NEAFVeLAGQVKEMTAY-A---Ke-----YDLTIAVMGCRVNGPGETDDADLGLWCAP-NF---VNLKKGTEALGAYPYD 360
NP_864753    298 NEAFIdLAAKVKEMTTF-A---Qe-----YSITIAVMGCRVNGPGETDDADLGLWCGP-AK---VNLKRGPEALGAFGYD 364
WP_075097023 297 NEAFIdLAAQVKEMAAY-A---Kd-----HAVTIAVMGCRVNGPGETDDADLGLWCGP-NF---VNLKKGPLELGAYSYE 363
WP_068804025 293 NEAFVdLAEQVRELTTY-A---Kd-----HHLTIAVMGCRVNGPGETDDADLGLWCGP-KQ---VNFKRRGELVGSFGYD 359
WP_077026537 294 NEAFVdLAEQVKEMTRY-A---Ed-----HSITIAVMGCRVNGPGETDDADLGLWCGP-NH---VNLKKGPESIGAYTYD 360
WP_096460564 296 NEAFIdLAEQVREMTRY-A---Aa-----HAVTIAVMGCRVNGPGETDEADLGLWCGP-NH---VNLKRGERSLGAFRYD 362
WP_096527063 294 NEAFIeLAQQVKAMTEY-A---Ad-----YAITIAVMGCRVNGPGETDDADLGLWCGP-KA---VNLKRGSETLGSYGYS 360
WP_011001165 403 RIAEDFQVIVDEY 415
WP_012911045 361 AILPRLQAELDSL 373
WP_013108888 361 EILPRLKQELDLV 373
WP_041399500 361 EIIPRLKQELDLL 373
NP_864753    365 EILPKLKQELDDL 377
WP_075097023 364 EILPRLKSELDRL 376
WP_068804025 360 EILPRLKTELDAL 372
WP_077026537 361 EILPKLKAELDAL 373
WP_096460564 363 EILARLKQELDAV 375
WP_096527063 361 EILPRLKQELDLI 373
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