Conserved Protein Domain Family
HMG-box_SoxH_SOX30
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cd22033: HMG-box_SoxH_SOX30 
high mobility group (HMG)-box found in sex determining region Y (SRY)-box 30 (SOX30) and similar proteins
SOX-30 is a crucial transcription factor that controls the transition from a late meiotic to a post-meiotic gene expression program and subsequent round spermatid development. It specially prevents Wnt-signaling to suppress metastasis. SOX-30 binds to the DNA sequence 5'-ACAAT-3' and shows a preference for guanine residues surrounding this core motif. SOX-30 is the only member of the group H of SRY-related high-mobility group (HMG) box (Sox) transcription factors.
Links
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Statistics
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PSSM-Id: 438842
Aligned: 14 rows
Threshold Bit Score: 132.927
Created: 8-Apr-2019
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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putative DNA
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:based on the structure evidence that Mus musculus SOX-4 binds DNA
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         # ## ## ##   #  #   #      ###  ##  #  ##                  #         # #### 
O94993        336 HVKRPMNAFMVWARIHRPALAKANPaANNAEISVQLGLEWNKLSe-EQKKPYYDEAQKIKEKHREEFPGWVYQPRP 410  human
XP_005993122  139 HIKRPMNAFMVWARIHRPALAKANPaASNAEISVQLGLEWNKLTe-EQKKPYYDEAQKIKEKHREEFPGWVYQPRP 213  coelacanth
CDQ73656      156 YIKRPMNAFMVWARIHRPALSKANPtANNADISVQLGIEWSKLTe-EEKRPYYVEARKLKDKHRQEFPGWIYQPRP 230  rainbow trout
XP_007889707  181 HIKRPMNAFMVWARIHRPSLAKANPnANNAEISVQLGLEWNKLTe-EQKKPYYDEAQKIKEKHREEFPGWVYQPRP 255  elephant shark
XP_006815472  221 HIKRPMNAFMVWARVYRPILAKEHPnANNAEISVKLGEVWHRMTd-LQKKPYYEESQKIKDQHKKDHPGWVYQPRP 295  Saccoglossus kowa...
PFX24800      165 KVKRPMNAFMIWARLYRSTIAKRYPnANNAEISVKLGEIWNELSt-EQQRPYFDEASRLKEKHRNEHPNWVYQPRP 239  Stylophora pistil...
NP_001071823  420 KIKRPMNAFMVWARQKRTIYAKNNPgLNNADISVRLGERWNSMTa-AQKQPYYDQADKIKADHKKEHPDWTYQPKP 494  vase tunicate
XP_011663630  653 KIKRPMNAFMIWSRQQRAVLARQRPkMTNADISVKLGVMWNDLDy-DVKQNYFDEAIQLKFQHRKDHPDWVYQPRP 727  purple sea urchin
XP_022091786  506 HIKRPMNAFMVWARIHRARLAHQFPhANNADISIQLGQSWNALTq-EQKQPFYDEAEKLRKLHRQEHPGWVYSPRP 580  crown-of-thorns s...
XP_002608275  146 HVKRPMNAFMVWARIHRPALARSHPrANNADISCQLGEKWSHELtnEDKKPYYEEACRLKSLHKKDHPGQMPSVAY 221  Florida lancelet

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