Conserved Protein Domain Family
PAG

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pfam15347: PAG 
Phosphoprotein associated with glycosphingolipid-enriched
PAG, or Cbp/PAG (Csk binding protein/phospho-protein associated with glycosphingolipid-enriched microdomains) is a transmembrane family that has a negative regulatory role in T-cell activation through being an adapter for C-terminal Src kinase, Csk. This family of proteins is found in eukaryotes.
Statistics
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PSSM-Id: 434654
Aligned: 11 rows
Threshold Bit Score: 434.221
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007659574   1 MGPAGGLLS-SG--QVPVVFWGSLATVGTFlLLLTFLLFLCSSCDREKKP--KQ-SGDHENLMNVPSDKGLLSHSVTSLT 74 
XP_012396700   1 MGPEGSLLH-GG--QVHIIIWGSLAAVATF-LLITFLIFLCSSCEREKKP--KQqNGDHENLMNVPSDKEMFSHSVTSLG 74 
XP_016848323   1 MGPDVGFFS-TS--LLHIIVWGGLAAMTML-LVLIFLIFLCSSCDREKRP--KQlNGDHENLMNVPSDKEVFSHSVTSLA 74 
XP_003205191   1 MGPDSGFLS-SG--RVHVILWGSLAAVTTL-LFLTFLIFLCSSCNREKKS--KHqNGDHENLMSVPSEKEVFSHSITSSA 74 
XP_004915220  17 SGEQAAFMA-----------WGGLAAVSTI-IFLSILLFLCSSCYREKKK--KHqNGDHENLMTAPSDKETYSHSVTSLG 82 
XP_005997607   9 IGDEEGLLS-SG--QPQVVLWGTLAAITSF-LLLNLLVFLCTSCEREQKA--KTqTEDHEILMNMPSDKETFSHSVTSLG 82 
XP_013126143  24 STGVASWLG-SG----QLILIATLSILTAL-LLVSVLLLLCASCQGQKKAvnGHpAGDHQSLVNGVSERDV-SQSADSPA 96 
XP_006102204   1 MGPSGSLLG--G--HLQIALWGSLAAAATF-FLITFLIFLCSSCDREKKP--RQySGDHENLMNVPSDKEVFSRSVTSLA 73 
Q9NWQ8         1 MGPAGSLLG-SG--QMQITLWGSLAAVAIF-FVITFLIFLCSSCDREKKP--RQhSGDHENLMNVPSDKEMFSRSVTSLA 74  human
Q3U1F9         1 MGPAGSVLS-SGqmQMQMVLWGSLAAVAMF-FLITFLVLLCSTCDREKKP--RQhSGDHENLMNVPSDKDMFSHSATSLT 76  house mouse
XP_003408410   5 MGPVGSMLSiSG--QVQIVLWETLAAVAIF-FLIAFLIFLCSSCDREKKP--RPqSGDDENLMNVTSDKEMFSHSVTSLA 79  African savanna...
XP_007659574  75 TDAAASSEPNGGLSNGDILSEDSTKAYTLPYEEVQTSVSDLLDSQESVGKSIKCHQSRELPRIPPNGTLEPILPPRTEAR 154
XP_012396700  75 TELPASSEQNGGLTNGDILSEDSTMTCMQHYEEVQTSISDLLESQDSTGKSAKCHQSRELPRIPPNDTLDTILTTSNVES 154
XP_016848323  75 TDPLASSEQNGGLSNGDVLSEDSTTACIQPYEEVQTSVTDLLEPQDSLGRSLKCHQSRELPRIPPNNAIETILSTRNTEN 154
XP_003205191  75 TEPPPSSEQNGALSNGDVLSEDSTTACIQPYEEVQTSISDLLE-QDSLGKSLKCHQSRELPSIPPNNTMETIISARNAEN 153
XP_004915220  83 TEAPASY-RNGAVSNGDV-SEDSSAACIQPYEDVQGSLPDLCDLQDCTSKSIRCHQSRELPRIPPNSNLETISPAEDDEN 160
XP_005997607  83 TDPPVSSCQNGELSNGDVLSEDNAGTNTQPSEEMKTSLPDLISQQDSMGKPLRYPQSRELPSIPPNSSVEGPKSSNATEN 162
XP_013126143  97 TDAAVSTSHNGPLTSGTILT-DTQDTSPQLSEEMLSSQSEL--------RSSKCPQDRELPSIPPNNALIGNGPPPSGDS 167
XP_006102204  74 TDAPLSSDQNGALTNGDIASEGSAGTCAQHYEEVLAAASDLLDAQDGSGKP-KGHQSRELPQIPPDSAVDTLASTGSVDG 152
Q9NWQ8        75 TDAPASSEQNGALTNGDILSEDSTLTCMQHYEEVQTSASDLLDSQDSTGKP-KCHQSRELPRIPPESAVDTMLTARSVDG 153 human
Q3U1F9        77 TDALASSEQNGVLTNGDILSEDSTLTCMQHYEEVQTSASDLLDSQDSTGKA-KCHQSRELPRIPPENAVDEILTARAADT 155 house mouse
XP_003408410  80 TDALASSDHNGALTNGDILSEDSTMTCMQHYEEVETSASDLLDSQDSAGRPSKCHQSRELPRIPPNSTVDTTVNASSVDG 159 African savanna...
XP_007659574 155 ERGLGTEGPYEVLKV--SCSQENMVEDCLYETVKEIKEAGASADADPSHGGghQEGSATAGRGLL-GSVSEGQTG----- 226
XP_012396700 155 DQGLGMEGPYEVLKD--SSSQENMVEDCLYETVKEIKEVGTSANLEKGQNG--RPNSVTAFKEIQ-GPQVLNKIE----- 224
XP_016848323 155 DQGLGMEGPYEVLKD--SSSQENIVEDCLYETVKEIKELGATSGTEKC-----KPKTAVLVNGSL-DHVLAHKVE----- 221
XP_003205191 154 DQGLGMEGPYEVLKD--SSSQENIVEDCLYETVKEIKDVGAAANMERSCNR--KSAASMMVTEDQ-DQIPECRIE----- 223
XP_004915220 161 ELPLGNEGPYEVLKD--SSSHENIIEDSLYETVKEIKDAHALPLNEETE----RSMDAVSPKRQE-FRIEAG-------- 225
XP_005997607 163 DQALVTDVTYEVLKD--SSSQDNIIEDSLYETVKELKEECGPARNDTASLS--RPSTTAEEVEAQsPENAAGATQ----- 233
XP_013126143 168 T--------YEVVKEmaVASRDVSADESLYETVKELKEPAAEAGLPNGTIQpsPDEPPPHPPALLnGHVSPSTPErgpif 239
XP_006102204 153 DQGAGAEGPYEVLKD--SSSQENMVEDCLYETVKEIKEAAAPPGKGPGG----RSRAAPAPKEPP-APQAPGRAD----- 220
Q9NWQ8       154 DQGLGMEGPYEVLKD--SSSQENMVEDCLYETVKEIKEVAAAAHLEKGHSG--KAKSTSASKELP-GPQTEGKAE----- 223 human
Q3U1F9       156 ELGPGVEGPYEVLKD--SSSQENMVEDCLYETVKEIKEVA-----DKGQGG--KSKSTSALKELQ-GAPMEGKAD----- 220 house mouse
XP_003408410 160 DQSGGMEGPYEVLKD--SSSQENMVEDCLYETVKEIKEVGATTHPDKGHNG--KSKSITTLKELP-EPQTQGKME----- 229 African savanna...
XP_007659574 227 -SAEYASVDRNKKGRQSLSAES----------VLGGLADLEEEAPPPVPVKLLDENENVWEKEDERSaavk-eeeGEASE 294
XP_012396700 225 -SAEYASVDRNKKSRHSVNAES----------ILGNSVDVEEEAPPPVPVKLLDENENVQDKVDGETv------nKGATE 287
XP_016848323 222 -SAEYASVDRNKKSRQSANSES----------PLSNTPDVEDEPPPPVPLKLLDENENVQEKEAEEE--------KEATE 282
XP_003205191 224 -SAEYASVDRNKKSRQSANSES----------PLDNTPDIEDELPPPVPMKLLDENENVQENEVDE---------GEGTE 283
XP_004915220 226 --AEYASVDHNRKSRQSINTQS----------AGSTPTSQEEDVPPPLPKKLLDENENVQSKEPEAEpeaepealKENIE 293
XP_005997607 234 -SAEYASVDWNKKSHRSQVLCA----------GDRASANSDEEAPPPVPTKILDENENVQNKGTE----------GEHLK 292
XP_013126143 240 aGAEYASVNLNKKSRHSADMEAkrrsgnaavpQQKPQEEPEEDLPPPVPEKVLDENDNQPALMM-----------NGLAE 308
XP_006102204 221 -FAEYASVDRNKKCRQSMNVDS----------VLGPARDAEEEAPPPVPVKLLDKNENLQAQD------------NSASE 277
Q9NWQ8       224 -FAEYASVDRNKKCRQSVNVES----------ILGNSCDPEEEAPPPVPVKLLDENENLQEKEGGEAe-------ESATD 285 human
Q3U1F9       221 -FAEYASVDRNKKCRHSANAES----------ILGTCSDLDEESPPPVPVKLLDENANLPQEGGGQAe-------EQAAE 282 house mouse
XP_003408410 230 -FAEYASVDKNKKCRQSANSEI----------VLGSSHDPEEETPPPVPVKLLDEKENLQEKEERPAd------eEGATE 292 African savanna...
XP_007659574 295 SPVDTSKRLSSLSYKSREDDPALTEEEISAMYSSVNK-P-GLANR--------------LAP--APSVAIQEVGPPRSPS 356
XP_012396700 288 STGQINKRLSSLSYKSREEDPTLTEEEISAMYSSISK-P-GQTLK--------------VPE--STYSCIQEVAPKRSPS 349
XP_016848323 283 GPSDPDKRLSSLSYKSREDDPSLTEEEISAMYSSVNK-P-GLATR--------------DLE--PAYTCIPEIAPQKSPS 344
XP_003205191 284 GASKPEKRLSSMSYKSREEDPSLTEDEISAMYSSVSK-P-GQAIR--------------AMD--SPYTCIQEITSQRSPS 345
XP_004915220 294 GASQDDKRQSLVSYKSREEDPCLTETDISAMYSTVSKtS-GQSFE--------------LQEefSHYAYIQDIAQDTSPT 358
XP_005997607 293 EASEVEKK--RLSYRVHGDGPPLTEEEISAMYSTVNR-P-AQSVK--------------SLE--CDYVEVKALSLERTPS 352
XP_013126143 309 AGLHNGELHSPPSPAPKFDNHVLSDNE-SAVYSTVNKtNcDDAVN--------------EEDkeHDYSSIAEIKGLVPAS 373
XP_006102204 278 GTQETNKRFSALSYKSREEDPTLTDEEISAMYSSVNK-P-GQSLK--------------VPE--SSDTCSP-GAARRSPS 338
Q9NWQ8       286 TTSETNKRFSSLSYKSREEDPTLTEEEISAMYSSVNK-P-GQLVNksgq-------sltVPE--STYTSIQ-GDPQRSPS 353 human
Q3U1F9       283 GTGGHSKRFSSLSYKSREEDPTLTEEEISAMYSSVNK-P-GQSAHkpgp-------cmkGPE--SACHSMK-GLPQRSSS 350 house mouse
XP_003408410 293 GTTEINKRFSSLSYKSREEDPTLTDEEISAMYSSVNK-P-GQSVNkpgqsvnksaqllqVPE--SSYTCIQDGAPQSSPS 368 African savanna...
XP_007659574 357 SSNDLYATVTDFENLTDGQe--pPPP--RRDNEPEPDYAAI---QSLGRDEGRAGPGPERGRPLPAQpESDYESIGDLHH 429
XP_012396700 350 SGNDLYATVRDFEKNPNIL----PPPgvHSNGEPEPDYEAI---QSLNKDEEKTVSMANGNHITFPK-ENDYESIGDLQQ 421
XP_016848323 345 ICSGLYASVKDLENTPNITt--fPQSgeRLNGELEPDYEAI---QTVHHDEDRNGLIPHSSQSTLSQ-ENDYESIGDLQQ 418
XP_003205191 346 VCSGLYASVKDFENTLSATt--vPQSagRPNGELEPDYEAI---QAVSQDEDRTLSVPHTNHIAPSG-ENDYESIGDLQH 419
XP_004915220 359 TCNGTYATVRDLDKSPDSIa--gPHAmdKANGGPDPEYEAI---ANLSREEERTMLYTNAGQTLLAHgESDYESIGDLVQ 433
XP_005997607 353 MNSDLYATVRDFEKEPNVLwptpSPSdqTIQQETDPGYEPI---SSVKNEDETTESQLSASPATDQKiENDYEIISEFQK 429
XP_013126143 374 SSGDLYATVRDIYSQPDEP---------GPADSTDPGYETIripKTNSSEDEHRAEGSDVGKA-----EPDYESVGELGL 439
XP_006102204 339 SCNDLYATVKDFEQPPSGAg--tLAPaaRPR-EPEPDYEAI---QALSREDEKATLEPSSLRGPFPK-ENDYESIGDLQQ 411
Q9NWQ8       354 SCNDLYATVKDFEKTPNST----LPPagRPSEEPEPDYEAI---QTLNREEEKATLGTNGHHGLVPK-ENDYESISDLQQ 425 human
Q3U1F9       351 SCNDLYATVKDFEKTPNSIs--tLPParRPSEEPEPDYEAI---QTLNREDEKVPLETNGHH--VPK-ESDYESIGDLQQ 422 house mouse
XP_003408410 369 SCNDLYATVKEFEKAPNSVs--tPPPaeRPSVEPEPDYEAI---QTLNREEEKATQETNGLHVLFPK-ENDYESIGDLEQ 442 African savanna...
XP_007659574 430 GKDFTRL 436
XP_012396700 422 SKDITRL 428
XP_016848323 419 HKDVTRL 425
XP_003205191 420 HRDVTRL 426
XP_004915220 434 NGDFTRL 440
XP_005997607 430 D-EITRL 435
XP_013126143 440 GPEMSRL 446
XP_006102204 412 CREVTRL 418
Q9NWQ8       426 GRDITRL 432 human
Q3U1F9       423 CRDVTRL 429 house mouse
XP_003408410 443 CRSITRL 449 African savanna elephant
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