3RHW,3RI5,3RIF,4TNW


Conserved Protein Domain Family
LGIC_TM_GluCl

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cd19062: LGIC_TM_GluCl 
transmembrane domain of glutamate gated chloride channel (GluCl)
This family contains transmembrane (TM) domain of the glutamate-gated chloride channel (GluCl) found only in protostomia but are closely related to mammalian glycine receptors. The transmembrane region consists of four transmembrane-spanning alpha-helical segments (M1-M4) that are linked by loops. The intracellular loop that links M1 and M2 determines the ion selectivity of the channel. These GluCl channels have several roles in these invertebrates, including controlling locomotion and feeding, and mediating sensory inputs into behavior. Comparison of the GluCl gene families between organisms shows that insect gene family is relatively simple, while that found in nematodes tends to be larger and more diverse. Glutamate is an inhibitory neurotransmitter that shapes the responses of projection neurons to olfactory stimuli in the Drosophila. GluCls are targeted by the macrocyclic lactone family of anthelmintics and pesticides in arthropods and nematodes, thus making the GluCls of considerable medical and economic importance. In Drosophila melanogaster, GluCl mediates sensitivity to the antiparasitic agents ivermectin and nodulisporic acid, suggesting that their drug target is the same throughout the Ecdysozoa.
Statistics
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PSSM-Id: 349864
Aligned: 16 rows
Threshold Bit Score: 133.631
Created: 16-Oct-2017
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 35 residues -Click on image for an interactive view with Cn3D
Feature 1:pentamer interface [polypeptide binding site]
Evidence:
  • Structure:3RHW: Caenorhabditis elegans glutamate-gated chloride channel (GluCl) transmembrane domain interacts with adjacent domains, and forms a homopentamer; contacts at 4.0A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1     #  ##      ## ##  #  ###  #### ### ##  ##     ## ##      ##          #   #  #   
3RHW_A    215 FYLLQLYIPSCMLVIVSWVSFWFDrtAIPARVTLGVTTLLTMTAQSAGINSQLPPVSYIKAIDVWIGACMTFIFCALLEF 294 nematode
NP_495489 266 FFLLQLYIPSSMLVGVAWVSYWIDwkSTAARVPLAIVTLLTMITTSHAINSNLPPVSYAKSIDIWVGACVVFIFFSLIEY 345 nematode
P91730    250 YYLVQLYGPTTMIVIVSWVSFWIDmhSTAGRVALGVTTLLTMTTMQAAINAKLPPVSYVKVVDVWLGACQTFVFGALLEY 329 barber pole worm
Q17328    247 YYLVQLYAPTTMIVIVSWVSFWIDlhSTAGRVALGVTTLLTMTTMQSAINAKLPPVSYVKVVDVWLGACQTFVFGALLEY 326 Caenorhabditis ele...
EEC16818  251 YYLIQIYIPCCMLVIVSWVSFWLDptSIPARVSLGVTTLLTMATQISGINASLPPVSYTKAIDVWTGVCLTFVFGALLEF 330 black-legged tick
EFV52763  262 FFLLQLYIPSSLLVAVSWVSYWIDwrAAAGRVPLSIITLLTMITHSYAINAKLPPVSYAKALDVWIGACIMFIFGSLIEY 341 Trichinella spiralis
EFV55070  288 FFLLQLYIPSSLLVVVSCLSYWIDwrASAGRMLLTIVTLLTLITQHYSVSANLPPVSYATAIDVWVGACVVFVFTSLVEY 367 Trichinella spiralis
EFX71888  238 YYLITIYIPCCMLVIVSWVSFWLDanAVPARVSLGVTTLLTMATQTTGINNSLPPVSYTKAIDVWTGVCLTFVFGALLEF 317 common water flea
CCN97896  257 FYVAQIYLPSTLLVVVSWVSFWLErtAVPARVTLGVTTLLTMTTQAAAINNSLPPVSYIKAVDVWIGTCLAFIFAAVVEF 336 Ostertagia ostertagi
CEF68378  290 FYLLHLYLPSTMMVIISFISFWLDptSVPGRVTLGITTLLTITTKSTGINSKLPPVSYIKAIDVWIGICTTFIFAVLIEF 369 Strongyloides ratti
Feature 1     #  ##                                                                           
3RHW_A    295 ALVNHIANagtt-------------------------------------------------------------------- 306 nematode
NP_495489 346 AVVNYVGIldehrqmkkaacnrsrlsnviendnfgeslqsltfspqekkrlirrrpkknmemq----------------- 408 nematode
P91730    330 AFVSYQDSqrqteqaksraarkaqkrrakmelvereqy------------------------------------------ 367 barber pole worm
Q17328    327 AFVSYQDSvrqndrsrekaarkaqrrreklemvdaev------------------------------------------- 363 Caenorhabditis ele...
EEC16818  331 ALVNYASRseshrqnmqkqkrkweleppmesdhledgtttfampl----------------------------------- 375 black-legged tick
EFV52763  342 AFVNYAGLreqf-------------------------------------------------------------------- 353 Trichinella spiralis
EFV55070  368 AFVNYIGLiqqqkriassypfqrlsnvqqdvfenlcqqstsgehhsspsfhdekydkysyfhyffhglrsrknsrrqlst 447 Trichinella spiralis
EFX71888  318 ALVNYASRsdahrekmkkqrkqwemehqaaldamaadgllddrnsfamk------------------------------- 366 common water flea
CCN97896  337 AIVSYCAApkhgpshhkeclcaareatdkdrssdevnrkvvga------------------------------------- 379 Ostertagia ostertagi
CEF68378  370 AFVTFLYNrkinrescpevyddsgllevekknsvikrtinkdktknhpndisipmi------------------------ 425 Strongyloides ratti
Feature 1                                                                         #           
3RHW_A    307 -------------------------------------------------------ewndISKRVDLISRALFPVLFFVFN 331 nematode
NP_495489 409 ----egdfeaiemvdrgpprsaglmeegwtfhdttdlvyigqrkrvelvrwcsvlssrgRAERIDIIARIIFPLAFILFN 484 nematode
P91730    368 ------------------------------qppctchlyqdyepsfrdrlrryftkpdyLPAKIDYYARFCVPLGFLAFN 417 barber pole worm
Q17328    364 ------------------------------yqppctchtfearetfrdkvrryftkpdyLPAKIDFYARFVVPLAFLAFN 413 Caenorhabditis ele...
EEC16818  376 -----------------------vhhhgdmhadklrqcevhmktpktnlckawlskfptRSKRIDVVSRIFFPLMFALFN 432 black-legged tick
EFV52763  354 -------------------------------------------------------kiaeIKANESQIESANFSTDQYDRP 378 Trichinella spiralis
EFV55070  448 srtqavdefnntesliinnpefsaeepcscvmsqraqrrlyhqlhlpaldtdfyflwndRAEKIDSIFRYLIPICFFFFN 527 Trichinella spiralis
EFX71888  367 ------------------plvpastevifmedgrdrgqqrndgmqtetccrtwigtytlRSKRIDVISRIIFPLVFAVFN 428 common water flea
CCN97896  380 -------------------------eakntemeplqasnvtrphkggfsfwrrwkegadPPKVIDLKSRIMFPVFFIVFN 434 Ostertagia ostertagi
CEF68378  426 ------------dsgydensqmspignnlmkfqdnglgslkwvknippiqyltmkfggpKAKRLDRYCRIIFPTLFLIFN 493 Strongyloides ratti
Feature 1            
3RHW_A    332 ILYWSRF 338 nematode
NP_495489 485 FAYWSIY 491 nematode
P91730    418 AIYWTSC 424 barber pole worm
Q17328    414 VIYWVSC 420 Caenorhabditis elegans
EEC16818  433 LVYWTTY 439 black-legged tick
EFV52763  379 IYANQDE 385 Trichinella spiralis
EFV55070  528 IVYWSVY 534 Trichinella spiralis
EFX71888  429 MAYWSTY 435 common water flea
CCN97896  435 LVYWTWY 441 Ostertagia ostertagi
CEF68378  494 ICYWFTF 500 Strongyloides ratti

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