6WJ2,6ULG


Conserved Protein Domain Family
Gtr1_RagA

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pfam04670: Gtr1_RagA 
Gtr1/RagA G protein conserved region
GTR1 was first identified in S. cerevisiae as a suppressor of a mutation in RCC1. Biochemical analysis revealed that Gtr1 is in fact a G protein of the Ras family. The RagA/B proteins are the human homologs of Gtr1. Included in this family is the human Rag C, a novel protein that has been shown to interact with RagA/B.
Statistics
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PSSM-Id: 398377
Aligned: 30 rows
Threshold Bit Score: 241.332
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6WJ2_F        32 KVLLMGKSGSGKTSMRSIIFANYIARDTRRLGATIDVEHSHVRFLGNLVLNLWDCGGQDTFMEN--YFTSQRDNIFRNVE 109
Q4Q0H2        10 KVLLMGLRKSGKSSIQKVVFEGMQPHDSATLATTVQPEKSTVHSNDFVNFEVWDFPGQNDPFDSsnASRYDVNQLLENCG 89  Leishmania major
Q38A82        10 KVLLMGLRKSGKTSIQKVVFEGMQPHHCVDLTTTVQPEKSTVCSYDFVNFEVWDFPGQTDPFDLnnTVHYDVGVLLENCG 89  Trypanosoma brucei
XP_002633370  28 TVILMGHKRSGKTSIRKVVFQKMSPNETMFVESTARITRDTIC-SSFINFETIEFPGQMCPFDD--S--LDPIGIFQKCE 102
EDN97763      74 RLLLMGQRRSGKSSISSVVFHKMPPNETLFLESTARIQKDSM--HSFMDFQVWDFPGQIDFQDA--Q--FDVEAIFGEIG 147
O74544         5 KIILMGLRRSGKSSIQKVVFYKMPPNETLFLESTSKLTQDHI--SSFIDFSVWDFPGQVDVFDA--A--FDFESIFTQVG 78  Schizosaccharom...
Q6C9K9        16 KVLLMGLRRSGKSSICKVVFHNMQPLDTLYIESTSKPVEEEF--NSLIDFSVQELPGQLNFFEP--DQYIDSDRLFQNVG 91  Yarrowia lipoly...
EDK42061      15 TILLMGLRRGGKSSICKVVFHNMQPLDTLYLESTSKPTNEQF--SSLIDLSVMELPGQLNYFEP--N--YDSERLFSSVG 88 
Q17AT2        41 RILLMGLRRSGKSSIQKVVFHKMSPNETLFLESTNKIVKDDINNSSFVQFQIWDFPGQIDFFDP--T--FDSDMIFGGCG 116 yellow fever mo...
Q54PK6        40 KIFLMGLKRSGKSSIQKVVFHKMLPNETLFLESTSKVVKNDISNSSFVQFQIWDFPGQLDFFDP--S--FDYEYILNNCG 115 Dictyostelium d...
6WJ2_F       110 VLIYVFDVEsRE-LEKDMHYYQSCLEAILQNSPDAKIFCLVHKMDLVQEDQRDLIFKEREEDLRRLSRPLE-------CA 181
Q4Q0H2        90 AIVYVLDCR--ElIDDARARLLDTISAAYRHNPELCVEVFIHKVDALSEDHQADLLASLQRRVEEEAKPLLenvqplrLN 167 Leishmania major
Q38A82        90 AIVFVMDCG--ElIDDSHARLVETVCAAYDRDPELSVEVFIHKVDKLSEDHQADLLTSLQRRVEAEARQRLnataqlrLN 167 Trypanosoma brucei
XP_002633370 103 ALLFIIDAQ--AeLQEPIATLVEYFCRAYKINQNIKFEVFVHKADGLTEEARVETKFNIYHQVKETIKDQIdvd--lqVT 178
EDN97763     148 ALIWVIDAQ--DdYLEAIARLNSTIFNLHQSFPNINIEVFIHKVDGLSDDYMLDIQRDIMQRIQDELSDQGmen--apVN 223
O74544        79 ALIFVIDAQ--DdYLDALARLHVTVARVVTINPNICIEVFIHKVDGLSDEFKIDTQRDIQQRTQDELADIGlen--vpIS 154 Schizosaccharom...
Q6C9K9        92 ALVYVIDSQ-DE-YLNALSNLHNIIEYAFKINPDINVEVLIHKVDGLSEDFRLDTQRDIMQRVSDELVDARlddgdvkLN 169 Yarrowia lipoly...
EDK42061      89 ALVYVIDSQ--DeYLNALTNLSMIIDFAYRVNPKINIEVLIHKVDGLSEDYRMDAQQDIMQRTGDELLDLGleg--vsVS 164
Q17AT2       117 ALVFVIDAQ--DeYIEALAKLNQTVTKAHKVNPRIKFEVFIHKVDGVSDDFKMESQRDIHSRATDDLADAGleg--vhLS 192 yellow fever mo...
Q54PK6       116 AIVFVIDAQ--DeIIEALQKLHQTIAKVYQINPNIHFEVFIHKSDGLSDDHKIDRQRDIQQKTTEELADANin---vhPS 190 Dictyostelium d...
6WJ2_F       182 CFRTSIWDETLYKAWSSIVYQLI-PNVQQLEMNLRNFAQIIEADEVLLFERATFLVISHYQCKEQrdvhRFEKISNII 258
Q4Q0H2       168 FNLTSIYDHSVFQAFSLVVQKLIkSKTPYITELLQMLNSNSNIDLSYLFLSHSKIYVAVDERNRLks-rTYDLCSDAI 244 Leishmania major
Q38A82       168 FNLTSIYDHSVFQAFSSVVQKLMkLQIPYITELLQILNSNSNLDLSYLFLSRSKIFLSVDERNRVkt-rTYEICSDAI 244 Trypanosoma brucei
XP_002633370 179 YHLTSIYDHSIFEAFSKVVQNLV-KQLPTLERLLDVFNNSSKVTKSFLFDILSKIYIATDS-EPVem-sIYELCCDMI 253
EDN97763     224 FHLTSIYNHSIFEAFSKVIQKLI-PHLATLEALLNDLCRNCRFEKAYLFDVLSKIYIATDS-SPVdm-pCYEICSDYI 298
O74544       155 FHLTSIFDHSIFEAFSRVIQKLI-PQLPTLENLLNIFCSNSLVEKAYLFDVLSKIYVATDS-SPVdv-qSYEICSDFI 229 Schizosaccharomyc...
Q6C9K9       170 FHLTSIFDHSIYEAFSRIIQKLI-PELPVFENLLNVLCSHSLFEKVFLFDVNSKIYVATDS-SPVdn-qTYEVCTDFI 244 Yarrowia lipolytica
EDK42061     165 FYLTSIFDHSIYEAFSRIVQRLI-PELPSLEHMLDNLVQHSNIDKVFLFDVNSKIYVATDS-LPVdi-qTYEVCAEFI 239
Q17AT2       193 FHLTSIYDHSIFEAFSKVVQKLI-PQLPTLENLLNIFISNSGIEKAFLFDVVSKIYIATDC-SPVdm-qSYELCCDMI 267 yellow fever mosq...
Q54PK6       191 FYVTSIYDHSIFEAFSKVIQKLI-PQLPTLENLLDVFISRSRIEKAFLVDVVSKIYVATDN-SPVdm-qTYELCSDMI 265 Dictyostelium dis...
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