2FFS


Conserved Protein Domain Family
AtaL

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pfam08982: AtaL 
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Acetylaranotin biosynthesis cluster protein L
This entry includes acetylaranotin biosynthesis cluster protein L (AtaL) from Aspergillus terreus, which is a non-ribosomal peptide synthetase. It is required for the biosynthesis of the toxin acetylaranotin, which is a disulfide bridged cyclic dipeptide. There are a number of steps in the biosyntheis of this epipolythiodioxopiperazine toxin from two phenylananines, but the specific function of AtaL has yet to be determined. homologs are also known from bacteria.
Statistics
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PSSM-Id: 430354
Aligned: 69 rows
Threshold Bit Score: 77.2405
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2FFS_B        11 DRTLV--DLPVLDRLQLWEGLVCRAREPQYFVVGLERFEI-LVDDGD-------RLHRRLYLPgl--------vVEDEVV 72  Pseudomonas aer...
WP_011763820  11 DLADP--HTTRLTREELWFGLLCRAEDARPFLPGLESCRI-VERSPN-------ELVRDLHFGaa--------vIRDRVR 72  Azoarcus olearius
Q5P4G1        11 DPADP--LLTELNREEVWFGLLCRAEDARPFLPGLEACMI-VERSES-------ELVRELQFGsa--------lIRDRVT 72  Aromatoleum aro...
BAL22386      11 DPANP--LASPLTREEVWFGLLCRVLDSRPFLPGLEACRI-LERTET-------EFRRELDFGsv--------vIRDQVT 72 
WP_011828052  11 DPADP--RVPPMSRAELWRGLLVRVESPQQFPLGPDRCEArAGAHAR-------ERRRSVHFGal--------rFEDTVQ 73  Methylibium pet...
WP_016475271  12 VPGLP----CEVTREELSGELADFAHRPEHFLEEVTKSEV-VSPERRgsepgsiAFERNIYFGhl--------vFHETVQ 78  Sutterella wads...
Q0CS65        15 VPINKdpSQPTLTLEEFWRGLHRGSEKPQLFAEYVADTEV-LPNSKSa-----nEFQRKLIMAngavhtakgveLLQDVR 88  Aspergillus ter...
EHY54829      14 VPVNPegVEPVVNAKEFWTGLRRGGARPELFAEYVAKTEV-MNQASDl------VFQRRLHMAdgavhtkggatIDQDVR 86 
CCT69463      10 QSVNPpdQNVVLNETELWYGIRRGGRNPHDFAPYVASCEV-LAGTKN-------EFRRKLTLAdgavhtaagedLIQDVI 81 
EHK22125      15 APANKptDETKLTSADLWLGVAHVARTPQEFAPYVAKCDV-LWETKNk-----qRLGRAVTLGdggvhtvnsqvLYQEVS 88 
2FFS_B        73 LKAPDSAHYSIKP-Saev--agGSLDXTIE--EPEPG-----SLFVRFAYCTRylqpLGD------ELPYD-AFVKQAYI 135 Pseudomonas aer...
WP_011763820  73 FAELEWISFESEA-Naeh--agGSLTIRIE--EPQPG-----ALFLRFIYATT----LPDvg--geDAKYA-DIVRSAYH 135 Azoarcus olearius
Q5P4G1        73 LMPMESIRFESER-Tash--pgGSLTITIE--EPAEG-----VLVLRFRYLTT----LPEeag-spDRAYA-EYVKAAYH 136 Aromatoleum aro...
BAL22386      73 VQPMDWVRFESER-Teth--agGTLTIAIE--EPAPE-----TMVLRFEYRTT----LSEhts-gdDVAYA-EFVKSAYH 136
WP_011828052  74 LEPEQRIVFTPEP-Hega--apVRLTVTIE--EPAPG-----ALFLRFVYETDdag--------saEEKALqGYRQQAWL 135 Methylibium pet...
WP_016475271  79 IGAD--GSYRSHA-AgsgerpaSDFSMQIE--EPEPG-----QLFIRFIYFED----RPEv---------------pTAI 129 Sutterella wads...
Q0CS65        89 NADGLLddg-------------------------------pdALYLTAVYELH----VPDvepgseRAKEIeREYAQLAL 133 Aspergillus ter...
EHY54829      87 LAENLMCEGVTIGnG-------SRSTMLLS--HGAQPtdgpnDLYLTAIYELH----VPDvepgssRAAEIeRDYTKLAK 153
CCT69463      82 IAPPLHVQAKTVStG-------ATSTFLLShgTTWQQdgerpVLFLTAMYELK----LDNvepgtqAAKDIeVNYTALAR 150
EHK22125      89 IADKLHVAATTLDtG-------AKTTFLVSyqPNAVVspdstDVSFTVIYELK----LAGvqpgsdKAKEIeRDYPELAR 157
2FFS_B       136 A--XDVETIATIRDRF 149 Pseudomonas aeruginosa PAO1
WP_011763820 136 Q--SDLDTLKMIRMIA 149 Azoarcus olearius
Q5P4G1       137 Q--SDLDTVRVIRMIA 150 Aromatoleum aromaticum EbN1
BAL22386     137 A--SDLDTLRVIRMIA 150
WP_011828052 136 E--LDRDMLRTLREWQ 149 Methylibium petroleiphilum
WP_016475271 130 EmnSREQQVDYLRRLA 145 Sutterella wadsworthensis
Q0CS65       134 G--AARTVVETIRRWK 147 Aspergillus terreus NIH2624
EHY54829     154 G--AANTVVQRIREWK 167
CCT69463     151 G--ACENAVKDIRKWK 164
EHK22125     158 K--ACVDTIEQIRESK 171
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