2OTM


Conserved Protein Domain Family
YjgF_YER057c_UK114_like_1
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cd02199: YjgF_YER057c_UK114_like_1 
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This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.
Links
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Statistics
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PSSM-Id: 100006
Aligned: 100 rows
Threshold Bit Score: 72.4927
Created: 8-Feb-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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homotrimerputative active
Conserved site includes 28 residues -Click on image for an interactive view with Cn3D
Feature 1:homotrimer interaction site [polypeptide binding site]
Evidence:
  • Structure:2OTM; Shewanella oneidensis putative endoribonuclease trimer
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                          ##  # #  # # ##                                              
2OTM_A       12 AAGLELPEVAAAlg----nYEPYSIVGSQLXTSGQFPylq---gklLYQGQLGady-tvSEGYAACRLATLNAIAQLKQA 83  Shewanella oneid...
YP_511386    10 DLGLRLPPPTRLpdglhlpFALINLRGDRLLFSGHPKtard-gsigGPFGTLGadm-stDQGYAEARDILLSVLANMKAE 87  Jannaschia sp. CCS1
YP_703973     9 DLGLVLPRAVQLppgvelpFSWVRVHGRRVLVSGHGPlaed-gtpaGPFGSVPadv-saADATHSARLTALAVLAGVRRA 86  Rhodococcus sp. ...
YP_468006    10 EMGLELPEPLKVrdglklpFTWVRVRGSRAYISGHVAcnpd-gtlaKPLGKVGaev-spEQGYASARLVALAHLASLKRA 87  Rhizobium etli C...
ZP_01851830   9 ELGLVFEPIEPGy------LKLCIRSGNQLLTSGHVS---------DQKGRLGenv-svEEGQAAARDCAIKILRSVRDE 72  Planctomyces mar...
ZP_01744409  11 EMGLDLPPSAPSra----lFLPGKITGNLLFLSGQICewe---gepKYFGPVAdgf-dmAEGQAAARMCALNLLFCIKKV 82  Sagittula stella...
ZP_02141833  11 KLGLELPPDWTPrg----qFLPFRRDGAIVYLSGQICewd---gavTHTGPAQdtpegiKTARKAAQICALNLLYRLREA 83  Roseobacter lito...
ZP_01093199  10 ELGFPVERTTPEgs----lVDAVSTVGNLLYASGQVPfdg---dqlKYVGKVPtev-slDDATQAAALCTANILRAVRKE 81  Blastopirellula ...
ZP_02735134  10 AAGFPLDRGPKEgp----vIDLLSVLGDTVYASGQVPyda---gvlTSKGKVPsqv-svEEATRAAALCAANILRAVVLK 81  Gemmata obscurig...
YP_770365    12 DMSIVLGGYREPas----rYKPAIRVGNLLYFSGQLSameydgvvaGITGQLGsei-gvDAGYEAARQCAIGLLNRAQTM 86  Rhizobium legumi...

Feature 1                # ## # #              #  #   #         #########         # # #  
2OTM_A       84 c-GELSrIKQIYRLEGVLNVHQSCIEHPKALDGASDLLLEIFGe--aGRHSRXIWTNpVXPLNSLCLVYLFAE 153 Shewanella oneidensis
YP_511386    88 i-DELSrITGWTRVFGMVTSAPGYTEQHLVVNGFSDLVVEVFGpe-iGRHARSAIGVaALPLGFAMEIEGEVS 158 Jannaschia sp. CCS1
YP_703973    87 v-GDLDlIGAWLTVTGFVNAEPGYDQTTAVLNGFSEVVLDVFGpd-vGDHARTAIGVaALPLNLPVVVAAELE 157 Rhodococcus sp. RHA1
YP_468006    88 v-GDLDrVTAWLRVFAMVNVAPGFNETPLVTNGYSDLILELYGpe-aGAHARSSIGM-AIPLNAPVNCEAEVE 157 Rhizobium etli CFN 42
ZP_01851830  73 h-GTLD-GLKVVKLLGCVNSTPDFTDQHLVINGASDLFHELYGksgdGYHARSALGFaALPTGVAVEIEAVFE 143 Planctomyces maris DSM ...
ZP_01744409  83 a-GSLSrVKEVVRLGGFVAAPPDFGDGPMIVNGASQLFIDLYGd--aGRHARTAVNVsSLPAKALVEVDAVIE 152 Sagittula stellata E-37
ZP_02141833  84 cdGDLDrVDAVLRLGGFVNCTSGFGQSPAVINGATELFIALFGe--dGWHARTAVGVsGLPGNAMVEVDAIVR 154 Roseobacter litoralis O...
ZP_01093199  82 i-GSLEtIERVVRITGYVNCEADFTQQHLVINGASQLVRDVFGe--aGRHARTALGMqQLPLGASVEVEMILL 151 Blastopirellula marina ...
ZP_02735134  82 l-GSLDrIERVVRVTGYVNTDPDFTDCHLVINGATDLLKAVFGpd-aGRHARTALGMgQLPLGTSVEVEAIFQ 152 Gemmata obscuriglobus U...
YP_770365    87 l-GDLSrIRQIARLTGYINSGPGFTDQHLVLNGCSDVLIAALGe--aGTHTRLAIGVvGLSFNTSVEVDCIVE 156 Rhizobium leguminosarum...

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