Conserved Protein Domain Family
RING-HC_RNFT2
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cd16742: RING-HC_RNFT2 
RING finger, HC subclass, found in RING finger and transmembrane domain-containing protein 2(RNFT2)
RNFT2, also known as transmembrane protein 118 (TMEM118), is a multi-pass membrane protein containing a C3HC4-type RING-HC finger. Its biological role remains unclear.
Links
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Statistics
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PSSM-Id: 438400
Aligned: 6 rows
Threshold Bit Score: 148.489
Created: 24-Mar-2015
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                       #  #           # #  #  #          #  #              
Q96EX2       369 GVRATGQQCTEAGDICAICQAEFREPLILLCQHVFCEECLCLWLDrERTCPLCRSVAVDTLRCWKDG 435 human
NP_001018369 368 GMRASAQQCGEAGDVCAICQAEFREPVALLCQHVFCEECLCLWFDrERTCPLCRSTVVETLRNWKDG 434 zebrafish
XP_007071966 373 GVRATSQQCSEAGDICAICQVEFREPLILMCQHVFCEECLCLWFDrEKTCPLCRSIAVETLRCWKDG 439 green sea turtle
AAH81207     315 GVRASSQQCAEAGDVCAICQGDFKDPLILICQHVFCEECLCLWFDrERTCPLCRSVAVETVRLWKDG 381 African clawed frog
XP_006001213 360 GVRATSQQCNEAGDICAICQVEFREPLVLACQHVFCEECVCLWFDtEKSCPLCRSVVTETLRCWKDG 426 coelacanth
XP_007900524 380 GVRATSQQCSESGDICPICQAEFRDPVMLICQHIFCEECACLWFDhERSCPLCRTAVTETLRCWKDG 446 elephant shark

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