Conserved Protein Domain Family
CathepsinC_exc

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pfam08773: CathepsinC_exc 
Cathepsin C exclusion domain
Cathepsin C (dipeptidyl peptidase I) is the physiological activator of a group of serine proteases. This domain corresponds to the exclusion domain whose structure excludes the approach of a polypeptide apart from its termini. It forms an enclosed beta barrel structure composed from 8 anti-parallel beta strands. Based on a structural comparison and interaction data, it is suggested that the exclusion domain originates from a metallo-protease inhibitor.
Statistics
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PSSM-Id: 462598
Aligned: 30 rows
Threshold Bit Score: 145.883
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EGR34889                      316 DLPVHCVKSEIV-GKWQIQISHPivkGNSrSMVTCGhevpDNPNTSFkasngkiqgvqqTFDIELTKDNKVLGE--LGEG 392
EGR30116                       23 DLPIHCLKNQVT-GYWILQRGKIeatNNErKMVSCGhqspDNENTSYkalngkldvvenEEIIKINPDFTVSGD--KGTG 99 
WGS:AAGF:cds.TTHERM_00445920A  23 DLPVHCVRSQIT-GKWLLKEGKVlasSNN-KPVSCGhqipDKAESSNsamggvlteverEYEVFLDEDFTVRGK--EGKG 98 
A0E8K5                         14 dLPVHCVRHQIV-GKWQLEFTEPqikGSG--PLTCGhnvpDNERTSQvagqnt-fvktsTHEVILTAKNNVVQKk-KLQG 88  Paramecium tetraurelia...
A0DDP2                         26 DLPVHCVRHQIV-GKWQLQFTEPqikGSG--PLTCGhnvpDNERTSQfagqnt-fqqafTHEVVLTAKNNVVLKk-KLQG 100 Paramecium tetraurelia...
A0E1S5                         18 DLPVHCLRHQIV-GKWKMEVSDVqlrGVG--AVPCGhhvpDTQHSSYkagwed-frasdSFELTLGNDYTVTDKdrKQSG 93  Paramecium tetraurelia...
A0DZB1                         18 DLPVHCMKHQIT-GKWKMEVSQTklkGMG--AVPCGhhvpDSQQSSYqagfdd-fkavdTFEVNLSNDYSVQDKerKTSG 93  Paramecium tetraurelia...
EFC36668                       23 DIPVHCLFHQVF-GDWTFYRTSTsfsNDV-VHNTCAltnpLPNVNVD------------TIKLRLLAPDVVYDEq-GNEG 87 
EFC37894                       31 DLPVHCLYNSTApGVWEFELTDQnmsGDD-VAAKCDi--rAPIQATR------------TMKVYLQMPDIAIDEk-GNTG 94 
ESO10294                       22 DTPVSCMYEDIR-GKWVFYVGNG---GYD-NNINCStmgyEVSKILF------------QYKLELKYPNIVIDEf-NNEG 83 
EGR34889                      393 TWTMIYDEGWEIDYGGIKFMNFFKYSKKElsLF----YKIDCGKTLvGWYNN--YTELNRGCSQ 450
EGR30116                      100 KWTLIYDEGWEIDYNNTKYTHFFKYYNQN--GN----YKTDCDNTLvGWFNS--YSVSQRGCSI 155
WGS:AAGF:cds.TTHERM_00445920A  99 RWTLVYDEGWEIEYNGVKYTHFFKYAKDDs-GQ----YKSVCSQTLvGWFNH--IQKKSRGCSQ 155
A0E8K5                         89 KWTMVYDEGFEVDFSKYKCFAFSKYKTNY--SG----AYSYCGETLiGWYQN--TETNERGCYR 144 Paramecium tet...
A0DDP2                        101 KWTMVYDEGFEVDFMHYKCFAFSKYKTNY--SG----AYSYCGETLvGWYQN--TKTNERGCYR 156 Paramecium tet...
A0E1S5                         94 SWTMVYDEGFEVEHNGVKYFAFSKYEPNG--VD----YKSLCGETLiGWYNN--QKTGEKGCYR 149 Paramecium tet...
A0DZB1                         94 QWTMVYDEGFEVEHNGVKYFAFSKYAPNG--SD----YKSYCGETLiGWYNN--LKTGEKGCYR 149 Paramecium tet...
EFC36668                       88 FWTLIYDQGFEVVINKQKYFAFFNYTQQG--KV----VTSNCGQTFtGWYHDagIAVKKFGCFR 145
EFC37894                       95 FFTLVYDQGFEVVVGGNKYWAFFNYTTAGkdSQgndiIISNCDRTFtGWYHEakVKAKSWGCYR 158
ESO10294                       84 TWTMIYDEGFEVTIHNRKFFAFSKFTGNM--FN----STSFCNETFpGWSHD--VFGRDWACYY 139
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