1MQ4,2BFY,1OL6,1OL5


Conserved Protein Domain Family
STKc_Aurora

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cd14007: STKc_Aurora 
Click on image for an interactive view with Cn3D
Catalytic domain of the Serine/Threonine kinase, Aurora kinase
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Aurora kinases are key regulators of mitosis and are essential for the accurate and equal division of genomic material from parent to daughter cells. Yeast contains only one Aurora kinase while most higher eukaryotes have two. Vertebrates contain at least 2 Aurora kinases (A and B); mammals contains a third Aurora kinase gene (C). Aurora-A regulates cell cycle events from the late S-phase through the M-phase including centrosome maturation, mitotic entry, centrosome separation, spindle assembly, chromosome alignment, cytokinesis, and mitotic exit. Aurora-A activation depends on its autophosphorylation and binding to the microtubule-associated protein TPX2. Aurora-B is most active at the transition during metaphase to the end of mitosis. It is critical for accurate chromosomal segregation, cytokinesis, protein localization to the centrosome and kinetochore, correct microtubule-kinetochore attachments, and regulation of the mitotic checkpoint. Aurora-C is mainly expressed in meiotically dividing cells; it was originally discovered in mice as a testis-specific STK called Aie1. Both Aurora-B and -C are chromosomal passenger proteins that can form complexes with INCENP and survivin, and they may have redundant cellular functions. The Aurora subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
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PSSM-Id: 270909
Aligned: 67 rows
Threshold Bit Score: 312.872
Created: 17-Jul-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Structure:1OL6: Human Aurora-A kinase binds ATP; contacts at 4A.
  • Structure:1MQ4: Human Aurora-A kinase binds Mg2-ADP; contacts at 4A.
  • Structure:2BFY: Xenopus laevis Aurora-B kinase binds inhibitor Hesperidin; contacts at 4A.

cd14007 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd14007 is a member of the superfamily cl21453
Sub-family Hierarchy
cd13968PKc_likecd00142PI3Kc_likecd00891PI3Kccd00896PI3Kc_IIIcd05165PI3Kc_Icd00894PI3Kc_IB_gammacd05173PI3Kc_IA_betacd05174PI3Kc_IA_deltacd05175PI3Kc_IA_alphacd05166PI3Kc_IIcd00895PI3Kc_C2_betacd05176PI3Kc_C2_alphacd05177PI3Kc_C2_gammacd00893PI4Kc_IIIcd05167PI4Kc_III_alphacd05168PI4Kc_III_betacd05164PIKKccd00892PIKKc_ATRcd05163PIKK_TRRAPcd05169PIKKc_TORcd05170PIKKc_SMG1cd05171PIKKc_ATMcd05172PIKKc_DNA-PKcd00180PKccd00192PTKccd05032PTKc_InsR_likecd05061PTKc_InsRcd05062PTKc_IGF-1Rcd05033PTKc_EphRcd05063PTKc_EphR_A2cd05064PTKc_EphR_A10cd05065PTKc_EphR_Bcd05066PTKc_EphR_Acd05034PTKc_Src_likecd05067PTKc_Lck_Blkcd05068PTKc_Frk_likecd05072PTKc_Lyncd05073PTKc_Hckcd05148PTKc_Srm_Brkcd14203PTKc_Src_Fyn_likecd05069PTKc_Yescd05070PTKc_Fyncd05071PTKc_Srccd05035PTKc_TAMcd05074PTKc_Tyro3cd05075PTKc_Axlcd14204PTKc_Mercd05036PTKc_ALK_LTKcd05038PTKc_Jak_rpt2cd05079PTKc_Jak1_rpt2cd05080PTKc_Tyk2_rpt2cd05081PTKc_Jak3_rpt2cd14205PTKc_Jak2_rpt2cd05039PTKc_Csk_likecd05082PTKc_Cskcd05083PTKc_Chkcd05040PTKc_Ack_likecd05041PTKc_Fes_likecd05084PTKc_Fescd05085PTKc_Fercd05042PTKc_Aatykcd05086PTKc_Aatyk2cd05087PTKc_Aatyk1cd14206PTKc_Aatyk3cd05043PTK_Rykcd05044PTKc_c-roscd05045PTKc_RETcd05046PTK_CCK4cd05047PTKc_Tiecd05088PTKc_Tie2cd05089PTKc_Tie1cd05048PTKc_Rorcd05090PTKc_Ror1cd05091PTKc_Ror2cd05049PTKc_Trkcd05092PTKc_TrkAcd05093PTKc_TrkBcd05094PTKc_TrkCcd05050PTKc_Muskcd05051PTKc_DDRcd05095PTKc_DDR2cd05096PTKc_DDR1cd05097PTKc_DDR_likecd05052PTKc_Ablcd05053PTKc_FGFRcd05098PTKc_FGFR1cd05099PTKc_FGFR4cd05100PTKc_FGFR3cd05101PTKc_FGFR2cd05054PTKc_VEGFRcd05102PTKc_VEGFR3cd05103PTKc_VEGFR2cd14207PTKc_VEGFR1cd05055PTKc_PDGFRcd05104PTKc_Kitcd05105PTKc_PDGFR_alphacd05106PTKc_CSF-1Rcd05107PTKc_PDGFR_betacd05056PTKc_FAKcd05057PTKc_EGFR_likecd05108PTKc_EGFRcd05109PTKc_HER2cd05110PTKc_HER4cd05111PTK_HER3cd05058PTKc_Met_Roncd05059PTKc_Tec_likecd05112PTKc_Itkcd05113PTKc_Btk_Bmxcd05114PTKc_Tec_Rlkcd05060PTKc_Syk_likecd05115PTKc_Zap-70cd05116PTKc_Sykcd05037PTK_Jak_rpt1cd05076PTK_Tyk2_rpt1cd05077PTK_Jak1_rpt1cd05078PTK_Jak2_rpt1cd14208PTK_Jak3_rpt1cd05117STKc_CAMKcd14082STKc_PKDcd14083STKc_CaMKIcd14166STKc_CaMKI_gammacd14167STKc_CaMKI_alphacd14168STKc_CaMKI_deltacd14169STKc_CaMKI_betacd14084STKc_Chk2cd14085STKc_CaMKIVcd14086STKc_CaMKIIcd14087STKc_PSKH1cd14088STKc_CaMK_likecd14089STKc_MAPKAPKcd14170STKc_MAPKAPK2cd14171STKc_MAPKAPK5cd14172STKc_MAPKAPK3cd14090STKc_Mnkcd14173STKc_Mnk2cd14174STKc_Mnk1cd14091STKc_RSK_Ccd14175STKc_RSK1_Ccd14176STKc_RSK2_Ccd14177STKc_RSK4_Ccd14178STKc_RSK3_Ccd14092STKc_MSK_Ccd14179STKc_MSK1_Ccd14180STKc_MSK2_Ccd14093STKc_PhKGcd14181STKc_PhKG2cd14182STKc_PhKG1cd14094STKc_CASKcd14095STKc_DCKLcd14183STKc_DCKL1cd14184STKc_DCKL2cd14185STKc_DCKL3cd14096STKc_RCK1-likecd14097STKc_STK33cd14098STKc_Rad53_Cds1cd05118STKc_CMGCcd07829STKc_CDK_likecd07835STKc_CDK1_CdkB_likecd07837STKc_CdkB_plantcd07860STKc_CDK2_3cd07861STKc_CDK1_eukcd07836STKc_Pho85cd07838STKc_CDK4_6_likecd07862STKc_CDK6cd07863STKc_CDK4cd07839STKc_CDK5cd07840STKc_CDK9_likecd07864STKc_CDK12cd07865STKc_CDK9cd07866STKc_BUR1cd07841STKc_CDK7cd07842STKc_CDK8_likecd07867STKc_CDC2L6cd07868STKc_CDK8cd07843STKc_CDC2L1cd07844STKc_PCTAIRE_likecd07869STKc_PFTAIRE1cd07870STKc_PFTAIRE2cd07871STKc_PCTAIRE3cd07872STKc_PCTAIRE2cd07873STKc_PCTAIRE1cd07845STKc_CDK10cd07830STKc_MAK_likecd07831STKc_MOKcd07832STKc_CCRKcd07833STKc_CDKLcd07846STKc_CDKL2_3cd07847STKc_CDKL1_4cd07848STKc_CDKL5cd07834STKc_MAPKcd07849STKc_ERK1_2_likecd07850STKc_JNKcd07874STKc_JNK3cd07875STKc_JNK1cd07876STKc_JNK2cd07851STKc_p38cd07877STKc_p38alphacd07878STKc_p38betacd07879STKc_p38deltacd07880STKc_p38gammacd07852STKc_MAPK15-likecd07853STKc_NLKcd07854STKc_MAPK4_6cd07855STKc_ERK5cd07856STKc_Sty1_Hog1cd07857STKc_MPK1cd07858STKc_TEY_MAPKcd07859STKc_TDY_MAPKcd14132STKc_CK2_alphacd14133PKc_DYRK_likecd14210PKc_DYRKcd14224PKc_DYRK2_3cd14225PKc_DYRK4cd14226PKc_DYRK1cd14211STKc_HIPKcd14227STKc_HIPK2cd14228STKc_HIPK1cd14229STKc_HIPK3cd14212PKc_YAK1cd14134PKc_CLKcd14213PKc_CLK1_4cd14214PKc_CLK3cd14215PKc_CLK2cd14135STKc_PRP4cd14136STKc_SRPKcd14216STKc_SRPK1cd14217STKc_SRPK2cd14218STKc_SRPK3cd14137STKc_GSK3cd05122PKc_STEcd06605PKc_MAPKKcd06615PKc_MEKcd06649PKc_MEK2cd06650PKc_MEK1cd06616PKc_MKK4cd06617PKc_MKK3_6cd06618PKc_MKK7cd06619PKc_MKK5cd06620PKc_Byr1_likecd06621PKc_Pek1_likecd06622PKc_PBS2_likecd06623PKc_MAPKK_plant_likecd06606STKc_MAPKKKcd06624STKc_ASKcd06625STKc_MEKK3_likecd06651STKc_MEKK3cd06652STKc_MEKK2cd06653STKc_MEKK3_like_u1cd06626STKc_MEKK4cd06627STKc_Cdc7_likecd06628STKc_Byr2_likecd06629STKc_Bck1_likecd06630STKc_MEKK1cd06631STKc_YSK4cd06632STKc_MEKK1_plantcd06607STKc_TAOcd06633STKc_TAO3cd06634STKc_TAO2cd06635STKc_TAO1cd06608STKc_myosinIII_N_likecd06636STKc_MAP4K4_6_Ncd06637STKc_TNIKcd06638STKc_myosinIIIA_Ncd06639STKc_myosinIIIB_Ncd06609STKc_MST3_likecd06640STKc_MST4cd06641STKc_MST3cd06642STKc_STK25cd06917STKc_NAK1_likecd06610STKc_OSR1_SPAKcd06611STKc_SLK_likecd06643STKc_SLKcd06644STKc_STK10cd06612STKc_MST1_2cd06613STKc_MAP4K3_likecd06645STKc_MAP4K3cd06646STKc_MAP4K5cd06614STKc_PAKcd06647STKc_PAK_Icd06654STKc_PAK1cd06655STKc_PAK2cd06656STKc_PAK3cd06648STKc_PAK_IIcd06657STKc_PAK4cd06658STKc_PAK5cd06659STKc_PAK6cd14131PKc_Mps1cd05123STKc_AGCcd05570STKc_PKCcd05587STKc_cPKCcd05615STKc_cPKC_alphacd05616STKc_cPKC_betacd05588STKc_aPKCcd05617STKc_aPKC_zetacd05618STKc_aPKC_iotacd05589STKc_PKNcd05590STKc_nPKC_etacd05591STKc_nPKC_epsiloncd05592STKc_nPKC_theta_likecd05619STKc_nPKC_thetacd05620STKc_nPKC_deltacd05571STKc_PKBcd05593STKc_PKB_gammacd05594STKc_PKB_alphacd05595STKc_PKB_betacd05572STKc_cGKcd05573STKc_ROCK_NDR_likecd05596STKc_ROCKcd05621STKc_ROCK2cd05622STKc_ROCK1cd05597STKc_DMPK_likecd05623STKc_MRCK_alphacd05624STKc_MRCK_betacd05598STKc_LATScd05625STKc_LATS1cd05626STKc_LATS2cd05599STKc_NDR_likecd05627STKc_NDR2cd05628STKc_NDR1cd05629STKc_NDR_like_fungalcd05600STKc_Sid2p_likecd05601STKc_CRIKcd05574STKc_phototropin_likecd05575STKc_SGKcd05602STKc_SGK1cd05603STKc_SGK2cd05604STKc_SGK3cd05576STKc_RPK118_likecd05577STKc_GRKcd05605STKc_GRK4_likecd05630STKc_GRK6cd05631STKc_GRK4cd05632STKc_GRK5cd05606STKc_beta_ARKcd05633STKc_GRK3cd14223STKc_GRK2cd05607STKc_GRK7cd05608STKc_GRK1cd05578STKc_Yank1cd05579STKc_MAST_likecd05609STKc_MASTcd05610STKc_MASTLcd05611STKc_Rim15_likecd05580STKc_PKA_likecd05612STKc_PRKX_likecd14209STKc_PKAcd05581STKc_PDK1cd05582STKc_RSK_Ncd05583STKc_MSK_Ncd05613STKc_MSK1_Ncd05614STKc_MSK2_Ncd05584STKc_p70S6Kcd05585STKc_YPK1_likecd05586STKc_Sck1_likecd08215STKc_Nekcd08217STKc_Nek2cd08218STKc_Nek1cd08219STKc_Nek3cd08220STKc_Nek8cd08221STKc_Nek9cd08222STKc_Nek11cd08223STKc_Nek4cd08224STKc_Nek6_7cd08228STKc_Nek6cd08229STKc_Nek7cd08225STKc_Nek5cd08528STKc_Nek10cd08529STKc_FA2-likecd08530STKc_CNK2-likecd08216PK_STRADcd08226PK_STRAD_betacd08227PK_STRAD_alphacd13973PK_MviN-likecd13974STKc_SHIKcd13975PKc_Dustycd13976PK_TRBcd14022PK_TRB2cd14023PK_TRB1cd14024PK_TRB3cd13977STKc_PDIK1Lcd13978STKc_RIPcd14025STKc_RIP4_likecd14026STKc_RIP2cd14027STKc_RIP1cd13979STKc_Moscd13980STKc_Vps15cd13981STKc_Bub1_BubR1cd14028STKc_Bub1_vertcd14029STKc_BubR1_vertcd13982STKc_IRE1cd13983STKc_WNKcd14030STKc_WNK1cd14031STKc_WNK3cd14032STKc_WNK2_likecd14033STKc_WNK4cd13984PK_NRBP1_likecd14034PK_NRBP1cd14035PK_MADMLcd13985STKc_GAK_likecd14036STKc_GAKcd14037STKc_NAK_likecd13986STKc_16cd13987STKc_SBK1cd13988STKc_TBK1cd13989STKc_IKKcd14038STKc_IKK_betacd14039STKc_IKK_alphacd13990STKc_TLKcd14040STKc_TLK1cd14041STKc_TLK2cd13991STKc_NIKcd13992PK_GCcd14042PK_GC-A_Bcd14043PK_GC-2Dcd14044PK_GC-Ccd14045PK_GC_unkcd13993STKc_Pat1_likecd13994STKc_HAL4_likecd13995STKc_MAP3K8cd13996STKc_EIF2AKcd14046STKc_EIF2AK4_GCN2_rpt2cd14047STKc_EIF2AK2_PKRcd14048STKc_EIF2AK3_PERKcd14049STKc_EIF2AK1_HRIcd13997PKc_Wee1_likecd14050PKc_Myt1cd14051PTKc_Wee1cd14138PTKc_Wee1acd14139PTKc_Wee1bcd14052PTKc_Wee1_fungicd13998STKc_TGFbR-likecd14053STKc_ACVR2cd14140STKc_ACVR2bcd14141STKc_ACVR2acd14054STKc_BMPR2_AMHR2cd14055STKc_TGFbR2_likecd14056STKc_TGFbR_Icd14142STKc_ACVR1_ALK1cd14143STKc_TGFbR1_ACVR1b_ACVR1ccd14144STKc_BMPR1cd14219STKc_BMPR1bcd14220STKc_BMPR1acd13999STKc_MAP3K-likecd14057PK_ILKcd14058STKc_TAK1cd14059STKc_MAP3K12_13cd14060STKc_MLTKcd14061STKc_MLKcd14145STKc_MLK1cd14146STKc_MLK4cd14147STKc_MLK3cd14148STKc_MLK2cd14062STKc_Rafcd14149STKc_C-Rafcd14150STKc_A-Rafcd14151STKc_B-Rafcd14063PK_KSRcd14152STKc_KSR1cd14153PK_KSR2cd14064PKc_TNNI3Kcd14065PKc_LIMK_likecd14154STKc_LIMKcd14221STKc_LIMK1cd14222STKc_LIMK2cd14155PKc_TESKcd14156PKc_LIMK_like_unkcd14066STKc_IRAKcd14157STKc_IRAK2cd14158STKc_IRAK4cd14159STKc_IRAK1cd14160PK_IRAK3cd14664STK_BAK1_likecd14000STKc_LRRKcd14067STKc_LRRK1cd14068STKc_LRRK2cd14001PKc_TOPKcd14002STKc_STK36cd14003STKc_AMPK-likecd14069STKc_Chk1cd14070STKc_HUNKcd14071STKc_SIKcd14072STKc_MARKcd14073STKc_NUAKcd14161STKc_NUAK2cd14074STKc_SNRKcd14075STKc_NIM1cd14076STKc_Kin4cd14077STKc_Kin1_2cd14078STKc_MELKcd14079STKc_AMPK_alphacd14080STKc_TSSK-likecd14162STKc_TSSK4-likecd14163STKc_TSSK3-likecd14164STKc_TSSK6-likecd14165STKc_TSSK1_2-likecd14081STKc_BRSK1_2cd14662STKc_SnRK2cd14665STKc_SnRK2-3cd14663STKc_SnRK3cd14004STKc_PASKcd14005STKc_PIMcd14100STKc_PIM1cd14101STKc_PIM2cd14102STKc_PIM3cd14006STKc_MLCK-likecd14103STKc_MLCKcd14190STKc_MLCK2cd14191STKc_MLCK1cd14192STKc_MLCK3cd14193STKc_MLCK4cd14104STKc_Titincd14105STKc_DAPKcd14194STKc_DAPK1cd14195STKc_DAPK3cd14196STKc_DAPK2cd14106STKc_DRAKcd14197STKc_DRAK1cd14198STKc_DRAK2cd14107STKc_obscurin_rpt1cd14108STKc_SPEG_rpt1cd14109PK_Unc-89_rpt1cd14110STKc_obscurin_rpt2cd14111STKc_SPEG_rpt2cd14112STKc_Unc-89_rpt2cd14113STKc_Trio_Ccd14114STKc_Twitchin_likecd14115STKc_Kalirin_Ccd14007STKc_Auroracd14116STKc_Aurora-Acd14117STKc_Aurora-B_likecd14008STKc_LKB1_CaMKKcd14118STKc_CAMKKcd14199STKc_CaMKK2cd14200STKc_CaMKK1cd14119STKc_LKB1cd14009STKc_ATG1_ULK_likecd14120STKc_ULK1_2-likecd14201STKc_ULK2cd14202STKc_ULK1cd14121STKc_ULK3cd14010STKc_ULK4cd14011PK_SCY1_likecd14012PK_eIF2AK_GCN2_rpt1cd14013STKc_SNT7_plantcd14014STKc_PknB_likecd14015STKc_VRKcd14122STKc_VRK1cd14123STKc_VRK2cd14124PK_VRK3cd14016STKc_CK1cd14125STKc_CK1_delta_epsiloncd14126STKc_CK1_gammacd14127STKc_CK1_fungalcd14128STKc_CK1_alphacd14017STKc_TTBKcd14129STKc_TTBK2cd14130STKc_TTBK1cd14018STKc_PINK1cd14019STKc_Cdc7cd14020STKc_KIScd14099STKc_PLKcd14186STKc_PLK4cd14187STKc_PLK1cd14188STKc_PLK2cd14189STKc_PLK3cd05119RIOcd05144RIO2_Ccd05145RIO1_likecd05146RIO3_eukcd05147RIO1_eukcd05120APH_ChoK_likecd05150APHcd05151ChoK-likecd14021ChoK-like_eukcd05156ChoK_eukcd05157ETNK_eukcd05152MPH2'cd05153HomoserineK_IIcd05154ACAD10_11_N-likecd05155APH_ChoK_like_1cd05121ABC1_ADCK3-likecd13969ADCK1-likecd13970ABC1_ADCK3cd13971ADCK2-likecd13972UbiBcd05124AFK
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                         #####   #             # #                               #       
1MQ4_A         13 DFEIGRp---------LGKGKFGNVYLAREKq-sKFILALKVLFKAQlekagvEHQLRREVEIQSHLrHPNILRLYGYFH 82   human
1OL6_A         11 DFEIGRp---------LGKGKFGNVYLAREKq-sKFILALKVLFKAQlekagvEHQLRREVEIQSHLrHPNILRLYGYFH 80   human
CAB11112     1379 DFIVDKy--------pIGNGRTGLVFKAIIKkeeNKKVALKVMAKDTimslniERQVLKEIIIQASLkHINILELIAYFE 1450 Plasmodium fa...
CAD98337       95 HFEIYDgie-----gvLGRGAYSSVFKIRSKr-sGNIYALKVMSVEHftcrglSGQLRREIQLQSQCfHPNIVQLYKCLE 168  Cryptosporidi...
CAK63948       68 DFQAMQq--------tLGQGSFGWVTLVKEIs-tGKLLAMKAMKKAElfkyctVDNLKREIKIQRKLnHPNIIKLDSYFE 138  Paramecium te...
CAK59378        9 EFEFVEkkdngkaqeeLGKGAFGRVRLAHDKv-tDTKVAIKTIPKKLlkenaqAENIKREIKLHRKLdHPHIVKLYHSLE 87   Paramecium te...
CAK73956       33 DFEVIQg---------LGQGAFGKVFKVRHKk-tKMVFALKQIAKKQikqqkmTQQIINEVKIMYGLeHPNIVKLYNHYE 102  Paramecium te...
CAK60351       32 DFEELKi---------LGQGAFGVVKKVTHKk-tNIVYAIKIVEKAMlkktnmVEQMQNEVKIMYSLnHPYILKLYNHFE 101  Paramecium te...
CAK89087       82 DYEFINgdk-----gmLGRGAFGEVRLAIDIe-lQQEMAIKILNKKKmlrncnLQQLKNEIKLQRSLnHPNIIQLYHAFE 155  Paramecium te...
XP_001007833   65 DYTFLDqkdk---kafLGQGSYGTVRLAIDKs-dGQKYAIKMMHKSTifqyctIDNLKREIKIQKRMnHPNICKLYHYFE 140  Tetrahymena t...
Feature 1                  # #                  #                                              ## 
1MQ4_A         83 DatRVYLILEYAPl---------------GTVYRELQKLs--kFDEQRTATYITELANALSYCHS--KRVIHRDIKPENL 143  human
1OL6_A         81 DatRVYLILEYAPl---------------GTVYRELQKLs--kFDEQRTATYITELANALSYCHS--KRVIHRDIKPENL 141  human
CAB11112     1451 DktRLFLILELANg---------------GSVRNKMKQKkq-pLNEEEVALYVFQIADALSYLHN--FNIIHRDLKPDNI 1512 Plasmodium fa...
CAD98337      169 HngYVFLILEKKKnhviragarrnryipsDEEYQEEESSl---FARNEVVSYLTQILKAINYLHE--MSIVHRDVKPENI 243  Cryptosporidi...
CAK63948      139 DktNVYLVLEYAEg---------------GSLFKQIKKQr--hLSEDEASHYLYQTCLGIDYLHK--QKIIHRDIKPENL 199  Paramecium te...
CAK59378       88 DetNVYLVLEYVPm---------------GNLFVYLKKRk--tLEEQEAFVYFLQTALALDYLHK--KGIIHRDLKPENI 148  Paramecium te...
CAK73956      103 EedYIYLILECATg---------------GQLWQKLNRVg--rFDEKTVKQFMQEAMSAIEYLHTrnPPIIHRDIKPENI 165  Paramecium te...
CAK60351      102 DdiNVYLILEFVGg---------------GQLYAVLWRQpqkkFDEKTSAKFILQACLALENIHS--KNIVHRDIKPENL 164  Paramecium te...
CAK89087      156 DreNIYFALEYASn---------------GSLYKYLRKLk--vMPEPEAFVYFFQTCLAVDYLHK--KNVIHRDLKPENI 216  Paramecium te...
XP_001007833  141 DkqYVYLVLEYAEq---------------GSLFHNLRKVk--kFSEELAFRFFYQTCLGIDHLHK--NSIIHRDLKPENL 201  Tetrahymena t...
Feature 1         #                     #                                                         
1MQ4_A        144 LLGs-----------aGELKIADFGWSVHAPs--sRRTTLCGTLDYLPPEMIEgr-mhDEKVDLWSLGVLCYEFLVGKPP 209  human
1OL6_A        142 LLGs-----------aGELKIANFGWSVHAPs--sRRTTLCGTLDYLPPEMIEgr-mhDEKVDLWSLGVLCYEFLVGKPP 207  human
CAB11112     1513 LIHysnehlnnkiykyGVIKLADFGFSCQLKnkrqKRSTFCGTIDYMPPEIINqi-pyDCNVDLWCLGIVIFELLVGFPP 1591 Plasmodium fa...
CAD98337      244 LISc-----------eGRVKLGDFGWCGDLCr---RCNSMAGTFCYMAPEILKge-rqTAKVDSWSVGILIYELYMGNVP 308  Cryptosporidi...
CAK63948      200 LLDn-----------kGNIKICDFGWSTEMGn---LKKAFCGTIEYMAPEMIKsq-stNYKLDIWCLGVLLYEMVQGKPP 264  Paramecium te...
CAK59378      149 LLDa-----------qGNIKICDFGWSAELQp---ERRTFCGTLDYMCPEMLNsq-nhDHRVDIWAMGILLFEMLHGHAP 213  Paramecium te...
CAK73956      166 LLDa-----------nGHIKIADFGWSNINNh---QRTTYCGTLDYLAPEMILec-ghDEKIDHWSLGVLIYELLTGKAP 230  Paramecium te...
CAK60351      165 LLDe-----------kQDIKLADFGWSNFLKpn-eIRQTFCGTLDYLAPEMLEksrqhDHQVDIWAVGVLCFELLTGLSP 232  Paramecium te...
CAK89087      217 LLDe-----------qGNVKLCDFGWSAESVe---MRSTFCGTFDYMAPEMLHnk-phDYRVDIWALGILLYELLHGNAP 281  Paramecium te...
XP_001007833  202 LIDg-----------kGDIKLCDFGWSAEQRns-iVRKTFCGTVDYMPPEMIEnq-phDHRVDIWCLGILLYELIHGYAP 268  Tetrahymena t...
Feature 1                                                                                         
1MQ4_A        210 FEAn----------tYQETYKRISR---VEFTFPDFVt------------EGARDLISRLLKhnPSQRPMLREVLEHPWI 264  human
1OL6_A        208 FEAn----------tYQETYKRISR---VEFTFPDFVt------------EGARDLISRLLKhnPSQRPMLREVLEHPWI 262  human
CAB11112     1592 FTDd----------tQERIFDQIKE---LNFHFPKSVs------------LLAQELILKLCSrtAEERISADEVKSHPWI 1646 Plasmodium fa...
CAD98337      309 FIPnnssggggrggrEGECDGNTNS---QVISMLNSIreiskdarpsrfpPDAWHLCCWLLRknSNERASPIQALNHPFL 385  Cryptosporidi...
CAK63948      265 FTGr----------nDQEKCQAILSg--SPLKYDEYVs------------EDCKSLISMILQqnPFNRPSIQGILSHRWM 320  Paramecium te...
CAK59378      214 YNKnr--------qsQEVVIKAILNaatTKIPFNDKIs------------NDAKDLIQALLKvnPLDRLSMEEIFNHKWI 273  Paramecium te...
CAK73956      231 FAPssqik--dqkesQKILEDNILK---VKINFPNDFp------------SLAKSLVLGLLQrdPQKRFNIQKMREHPWF 293  Paramecium te...
CAK60351      233 FAPqinin--nqtfvEKTTKDNIVN---LRFQFPPTFp------------AQAQDLIKKILVkePGKRFTCQQIKEHQWI 295  Paramecium te...
CAK89087      282 FTK------------AHFAKENISN---LTIKFSQSVs------------SQAKNLITSILQhdPKKRMSMDQIFAHQWL 334  Paramecium te...
XP_001007833  269 FLGh----------dDQTKLKNIRNr--QEIVFEPFVp------------KDLEELIRGILQhnPLHRLSMDDIFRHRWM 324  Tetrahymena t...
Feature 1          
1MQ4_A        265 T 265  human
1OL6_A        263 T 263  human
CAB11112     1647 K 1647 Plasmodium falciparum 3D7
CAD98337      386 A 386  Cryptosporidium parvum
CAK63948      321 L 321  Paramecium tetraurelia
CAK59378      274 K 274  Paramecium tetraurelia
CAK73956      294 A 294  Paramecium tetraurelia
CAK60351      296 V 296  Paramecium tetraurelia
CAK89087      335 K 335  Paramecium tetraurelia
XP_001007833  325 V 325  Tetrahymena thermophila

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