4DAP


Conserved Protein Domain Family
SfsA-like_bacterial
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cd22359: SfsA-like_bacterial 
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Sugar fermentation stimulation protein A and similar proteins
Sugar fermentation stimulation protein A may bind to DNA in a non-specific manner and may act as a regulatory factor involved in the metabolism of sugars such as maltose. However, it contains a well-conserved PDDEXK nuclease active site and may have hydrolytic activity towards an unknown target. The putative catalytic domain belongs to a superfamily of PDDEXK nucleases including very short patch repair (Vsr) endonucleases, archaeal Holliday junction resolvases, MutH methyl-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and FokI. The N-terminus of SfsA resembles a DNA-binding OB-fold domain.
Links
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Statistics
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PSSM-Id: 411763
Aligned: 209 rows
Threshold Bit Score: 161.504
Created: 28-Jul-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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putative active
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:putative active site [active site]
Evidence:
  • Structure:4DAP: Escherichia coli SfsA active site binds cation; contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
4DAP_A     12 LIQRYKr---fLADVITp--dGRELTLHCPNTGAmtgcatPGDTVWYSTSDntk--------rkyPHTWELTQSqsGAFI 78  Escherichia coli K-12
RKZ00479   20 YFLQRLn---kFLGKVKl--dGREAFVFIPNPGRmeelliEGAEVVLIPKNspn---------rkTRFDLVGVKhgSTWV 85  Candidatus Hydroth...
RLA86041   39 TFLNRVn---rFLVEVQv--eGRVQKAFLPNSGRlqgvliPGRTVLLKPQNsvs---------rkTVLDLWGVFdgRIWI 104 Deltaproteobacteri...
RLB07399   10 IFVERRn---rFLVLVEv--nGMLKEAHLPNSGRlrellvPGATALVREVSqqg---------rkTPYDLWGIYtgKNWV 75  Deltaproteobacteri...
RLA80112   14 TFEERLn---rFLVSVRv--eGKTERAHLPNSGRlkellvRGRRVLLVPSRsrg---------rkTPFDLWGVEgdRGWV 79  Deltaproteobacteri...
OLS31997    8 LFARFLsrpnrFLATVKlensREIVEVHVPDPGRleelllSDLEVIVRQEEskn---------rrTRYTLVGVKtgLIWV 78  Candidatus Heimdal...
RME43878   11 TFVRRDn---rFRATVLv--gGRFTKAHVPNSGRlhelfrPGQSVLLAHVPaph---------rvTDYDLIMVRlgDQLV 76  Chloroflexi bacterium
VVB63226   11 KFLERTs---rFTVIAEr--dGRLLDCFLANPGRlkellvPGHNLLLRCVVpgg--------tkkTGFDVIGVCleGKVV 77  uncultured archaeon
Q67QV9     15 TFLERPn---rFVARVRle-dGREVPVHVASSGRmkellvPGAPVIVTLQGdasaqptrpfggrkTAGRLLMVRtgSTWV 90  Symbiobacterium th...
GBC74911    5 SFVKRKn---rFTCIVKl--kDRLEEAYLPNPGRleeiliPNNILYLVPSFk------------kLPYMIIGGKvgDELV 67  archaeon HR06

Feature 1            #                       #          #              # #                    
4DAP_A     79 CVNtlWANRLTKEAILNEsiselsgysslKSEVKYgaerSRIDFMLQads-rpDCYIEVKSVTLa---ENEQgy--fPDA 152 Escherichia coli K-12
RKZ00479   86 SIDsrMPNRFFEDAVKHSilpdfkgvdvaKSEFRFa--sSRFDFLLEdp--ehHYLVEVKSCTLv---RDGVam--fPDA 156 Candidatus Hydroth...
RLA86041  105 LVDsrMANRLLPWTISKGtipylrdlsdlKPEVKRg--gKRFDFFAYwr--gkDLWIEAKSVTLv---RDGLal--fPDA 175 Deltaproteobacteri...
RLB07399   76 CVDarYANDLFLKALRQGlieklkwytsvDKEVNFg--pRRLDFTVKkg--gnRHLIEVKSVTLv---REGIal--fPDA 146 Deltaproteobacteri...
RLA80112   80 CIDsrMANNLFLQALSSGlipefrgdeevEREVTLs--gRRIDFLLRqg--gkGYWVEVKSVTLv---KGDLal--fPDA 150 Deltaproteobacteri...
OLS31997   79 NIEsiFTNDIFRQEFHKLekfkh--lelvRSEFTFg--kSRFDFLMKnkktnkQELVEIKGATLv---ENQIal--fPDA 149 Candidatus Heimdal...
RME43878   77 SMDarLPGRLFHEAVAAGrldafagythiEPEVRFg--eSRLDFRLEka--geQCYVEVKSVTLv---EDGCgl--fPDA 147 Chloroflexi bacterium
VVB63226   78 TIDsrIPNAMTREALCARslrefqgysvvRSEPAFg--sGRFDFLLDp-----PCFVEVKSCTLv---KNGVal--fPDA 145 uncultured archaeon
Q67QV9     91 SVDtsLPGKLFHQAVVAGscapfagytevRPEYRYg--gSRIDFLLTapd-lpPCLVEVKSVTSvlpdADGArvarfPDA 167 Symbiobacterium th...
GBC74911   68 SLDsrLPNKIVYEELLSKrmsifgsykriLKEFKVn--kSKFDFLLLng---kRKLLEVKSVTLv---INRIgl--fPDA 137 archaeon HR06

Feature 1                                                                                     
4DAP_A    153 VTERGQKHLRELMSVAaeg----------qrAVIFFAVLHsaITRFSPArhIDEKYAQLLSEAQQrGVEILAYKAEisa- 221 Escherichia coli K-12
RKZ00479  157 PTTRGVRHVRELIEVAknhgtlkpnstkrllAAIVFVIQRddAEYFMPNyeMHPEFGEVLKEAYHgGVKVVAYRTRfdpq 236 Candidatus Hydroth...
RLA86041  176 PTPRGRDHLKALRGLSskg----------saALVTFMVLRedASAFAPNreIDPGFAEALTEAVEgGVMVEALCFTvge- 244 Deltaproteobacteri...
RLB07399  147 PTVRGRKHLELLTKAAkrg----------qkGGVVFIVQRkdAHSFSPNkeTDPAFATALHKAASqGIWVVACKFEikkg 216 Deltaproteobacteri...
RLA80112  151 PTQRGTEHLRLLTSLRerg----------ggAGVFFIIQRgdARAFSPNdeTDPQFASSLKDAAKrGVLVGAISFQvgr- 219 Deltaproteobacteri...
OLS31997  150 PTKRGARHVRELGEAVtkg----------wnAHVVFIIKRndAISFKPNekMDPKFAEELKLAQQkGVKLTAAICEyd-- 217 Candidatus Heimdal...
RME43878  148 PTLRGQRHVRELMAARrag----------hrAAAVFVIQRsdARCFRPHatADPAFAEVLQEAREaGVEVYAFTCV---- 213 Chloroflexi bacterium
VVB63226  146 PTARGRRHLLEMSEALkqg----------yrCVVIFVVQRddARLFRPNseTDPEFSKALLETYSsGVEAIAYTTKyvd- 214 uncultured archaeon
Q67QV9    168 PTARGARHLDELAGAVreg----------yrAAVCFITQRddAQAFGPWdeIDPFFGETLRKVARaGVEIRAFVTHvtp- 236 Symbiobacterium th...
GBC74911  138 PTERGRRHLLDMVKLIdeg----------yeCNLLFVIQRsdADFFKPNkeRDEGFYDAFKRAYEkGVNIQAIKFKkivn 207 archaeon HR06

Feature 1                  
4DAP_A    222 -egmALKKSLPVT 233 Escherichia coli K-12
RKZ00479  237 slrlIYLDQLPIK 249 Candidatus Hydrothermae bacterium
RLA86041  245 -gtvLDAKRIPVI 256 Deltaproteobacteria bacterium
RLB07399  217 -wvgRGERIPVVL 228 Deltaproteobacteria bacterium
RLA80112  220 -gwiGEGRRVPIT 231 Deltaproteobacteria bacterium
OLS31997  218 ---pIITKEIAIV 227 Candidatus Heimdallarchaeota archaeon AB_125
RME43878  214 ----VTLDQVVID 222 Chloroflexi bacterium
VVB63226  215 -rliELARRIEVE 226 uncultured archaeon
Q67QV9    237 -egaVLGGELPVR 248 Symbiobacterium thermophilum IAM 14863
GBC74911  208 fkdiELDGFVKVL 220 archaeon HR06

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