Conserved Protein Domain Family
BORCS6
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pfam10157: BORCS6 
BLOC-1-related complex sub-unit 6 C-terminal helix
This is a family of conserved proteins found from nematodes to humans. Family members include BORCS6 (BLOC-1-related complex sub-unit 6) also known as Lyspersin (lysosome-dispersing protein) or C17orf59. It constitutes sub-unit 6 of the BORC complex (BLOC-one-related complex). BORC is a multisubunit complex that regulates the positioning of lysosomes at the cell periphery, and consequently affects cell migration. BORC associates with the lysosomal membrane, where it functions to recruit the small GTPase Arl8. This initiates a series of interactions that promote the microtubule-guided transport of lysosomes toward the cell periphery. this entry represents a C-terminal alpha helix according to structure predictions.
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Statistics
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PSSM-Id: 462969
Aligned: 46 rows
Threshold Bit Score: 83.0031
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
RKP12016       22 GPDPDTYRLlATLEVDARALSARLDALLHQLQNELSDSSDSTQESIVVFHDVVEATCASVDAMVERTGVLVDRCEKLDRS 101 
GAQ84065       96 SIPVAVEVL-AEVEKDASNVANNLVQLMATLRASLADVTHCSLEHLECHSEAARELHEAVTDAASSGNRFINECQRLDQE 174 
XP_016502684   41 GKEI-LKAI-QVVERDSMAIAESFTSLFASLRSTLSEVTSTSVDHMNCFGDAAGRVQECALDAATKGNRYINSCLRLNEE 118 
PNR44714       76 DIATAVKLV-KAVEDDAKAVAGSLVGLFSSLQSALSEVTGSSVDHMKCHSEAAGLLQDASIDAAAKGQRFINACLRLNEE 154 
Q54Q24        349 LTNVGFATL-KNIECNAIKCSEEVVLLTKTLHQSLSTITKISIELFETFNGSTEVTCNAIGYSVNETKTMIDKCFELNNH 427  Dictyostelium...
KYQ89352      233 LTNVGFKTL-KSIEMDAMKCSESVIALTRSLNYSLQMMTKMSVELFHAYKMSTDSLCQNAVNSMRETEIMITRCIELNEQ 311 
EFA85884      368 LSNVGFNTL-KSVEMDSLRCAESVVTLTRNLNYSLMVMSRMSVELFNNLKMSNDMVCFTIGGGVGQTEKLINKCIELNEQ 446 
CEI95306        4 EANIDLDFF-ESLESKSQQLFQQFVDHVSKVQEQMQQMSTSTTELGHVYLSSTQHLCEELEASTRKSIELITHCDELDKD 82  
OAJ39700       20 SVPLDPSLL-EEIELQAETIGQELAQLIQNLQIRLKEISGYTLESVELHKVAVDKLCDAVEENIVHTSEFVQVVDDISQD 98  
EFA78619      325 KPEEFQQLL-TRIKENSAHYGAQFNDLVNRTKVINHSMSHIMMENFENYSKTCTDVLDETYHSMESMKTLINSMELLNSD 403 

RKP12016      102 LNLIHPLSHQIKGIKQALVALE 123 
GAQ84065      175 MRDVGELAAQIKAMRQLVDHFE 196 
XP_016502684  119 MKGIDNLATQLKIIRRNVDALD 140 
PNR44714      155 MKSVGNLAAQLKALRQVVDQFE 176 
Q54Q24        428 TKSVISLHQKIKTVRDQLDKFD 449  Dictyostelium discoideum
KYQ89352      312 TKSIQNLHQKIKLIKENINRFE 333 
EFA85884      447 AKSMTLLHQKIKQIREYVDKLE 468 
CEI95306       83 LLQLQELARQIKSVDKALDQLQ 104 
OAJ39700       99 MLTVQRLSQQIADIRGSLDWLE 120 
EFA78619      404 LFHVYKLASQIKHIKKSLDLLD 425
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