Conserved Protein Domain Family
DPCD
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pfam14913: DPCD 
DPCD protein family
This protein is a found in eukaryotes and a mutation in this protein is thought to cause Primary Ciliary Dyskinesia (PCD). This protein is 203 amino acids in length, 23 kDa in size and its function remains unknown. The gene that encodes this protein is a candidate gene for PCD and is expressed during ciliogenesis. PCD affects the airways and reproductive organs, and probing Northern blots show DPCD expression in humans is highest in the testes. Additionally, there is no indication of major splice variants.
Links
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Statistics
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PSSM-Id: 464369
Aligned: 28 rows
Threshold Bit Score: 248.318
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_001956075   6 WLNYLQSAEKNSMISGRLRKVLYKFPDGQQMAEEYNMDTGIIQRRAWRKCKQLMGEPEWEIELGEEPRQLNwsgnkqtgp 85 
2_pfamImport   1 WVELLTAARKTALLQEGRRKIHFTMSDGAELLEEYDVRSNELLVRKWRRKSALGGQKGWEYEVGEADLTAK--------- 71 
EDV20765       4 WVEMLKSSQKTCLVQDGRKKIHYTFKNHTEMAEEYDMATFDLSVRKFRKKSTLGSSGQWEYEIGEATNITN--------- 74 
EDO40351      11 WLETLRNARKTSLVQDGKRKIHFTFADGTQMVEEYSVANGELLVRKWKKKTTLGKECKWEYEIGEEVQPVN--------- 81 
Q0IEH0         6 WLTKIRGADKSSAIQGTVRKVHYSFPDGTEMAEEYSTETGCVLRRAWKLRSDLLRKDDWEIELGEPIPK----------- 74  yellow fever mo...
XP_004932676  37 WYHTLLDAEKSCLKEEKVKKIHYKFEDGREMVEEYNVDTQVLLRRAWKVKGKLGGEGKWHVEIGDPIPDAI--------- 107
EEZ97894       3 WLSQLKSAKKSCMVQNNLKKVHYDFGNGKEMVEEYNMDTNVVTRRAWKVKGEMGGEGEWDIELGDPEVNPT--------- 73 
XP_002431095   6 WLTAISNSEKTCIIQD----VHFKFSDGQEMVEEYNLETNVVVRRAWKVTKKFGSQPKWEVEIGDPEPCFQ--------- 72 
EFN69346       6 WLKIIQNAKITVLIEDGKRKVHFLFENGKEMVEEYNMDTNVVVRRLWKKKNNFGTDIGWIVEIGEPEPK-E--------- 75 
XP_012062541   6 WLKIIQNARKTAVIEDGKRKVHFLMEDGKEMVEEYSTDTNVVVRRAWKEKNGFGTNIGWMVEVGDPELK-Q--------- 75 

XP_001956075  86 ggdADSlagSEFTVRESNTAPLLTKRVTKKNIEWRIRNMPYALEVYNVTASPEQRAIIVRTTNKKYYKVIPVPDLDRCGV 165
2_pfamImport  72 ---FAAlshGSEHVVESHENPICFRCDTKKLFQWRIRNLPFPTSTYELSIRDQ--SIVVRTSNKKYFKILQIPDMERYGL 146
EDV20765      75 ---I-----EELSIRESNTTPRFSAKYSKNAFQWRIRNLPYPLDNYSITVDDEKRQLVLRTKNKKYFKRISIPDMDRFHL 146
EDO40351      82 ---I-----DSEHIMESRANPIFIRKDVNKAFQWRVRNLPYPLEVYSVTVDDDRKTITTRTNNKKYFKKFSIPDMVRAEL 153
Q0IEH0        75 ---ALKndhDGFALQEAATEPFLSKRVTRNCIEWRIRNLPYPLSTYTITCEGDARTITVRTSNKKYFKKIAVPEFQRCGF 151 yellow fever mo...
XP_004932676 108 ---SNS---DCAEITECKDQPQVFRRNTRINLEWRIRNLPYPIETYSISANNDERCIVIRTTNKKYFKKFKIPELERLNL 181
EEZ97894      74 ---Ke----QNLIIRENSGQPVVSRRNTRINLEWRIRNLPYPIETYSVTVDNEKNCLVVKTTNKKYYKILRVPELDRLRI 146
XP_002431095  73 ---EDM---ENSGIKESSTAPTTTARITKNCLEWRIRNLPYPIDNYTVLASQDDNCIIVKTKNKKFFKKIRVPDLERIGV 146
EFN69346      76 ---NNI---EKDGIQESSNTPFVTQRITKTCLEWRIRNLPYPSNVYSVTAEEDN-TITVRTSNKKYFKKLKVLDLERIGL 148
XP_012062541  76 ---NNI---EIYGIEESSNTPIITRRITKASLEWRIRNLPYPESVYSITAEHDG-TMTVRTSNKKYFKKIKIPDLERIGL 148

XP_001956075 166 APAQDNISVHHQFNTLIITYKKPDILCEMEAQVLLLLKNVETETD 210
2_pfamImport 147 SLNESELSFAHANNTLIVQYKKPVEIITDQDMLMVEFKKMKVTKE 191
EDV20765     147 PLDQNAVKLAHANNCLIISYQKPSQIIEHEKALHKELRKMKASKD 191
EDO40351     154 PLDQSSISLAHANNTLIISYAKPPMILEQEKLIKVELAKTQGSKE 198
Q0IEH0       152 APKVEDLMVKHQYNTLIIAYKKPAILVEMEKAVLAELQNVETVEY 196 yellow fever mosquito
XP_004932676 182 NIEQANIQSSHHFNTLIIMYKKPQQLLDMEKEWYEELKKVKPIKD 226
EEZ97894     147 APQHEAIQIAHKYNTLIITFKKPKELLEFEKKVLEEVSKIQPKNF 191
XP_002431095 147 KLEQDKIDYSHKFNTLIISYKKPPQLILSEKLILEEVNKLKSVKE 191
EFN69346     149 KPEQERISFKHQYNTLIITYKKPLELLNVEKKILSRILQFKPIES 193
XP_012062541 149 KPEQERISFRHQYNTLIITYKKPPQLLNMEKKILAAVLQLKTDSK 193
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