Conserved Protein Domain Family
bHLHzip_SREBP2
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cd18922: bHLHzip_SREBP2 
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding protein 2 (SREBP2) and similar proteins
SREBP2, also termed Class D basic helix-loop-helix protein 2 (bHLHd2), or sterol regulatory element-binding transcription factor 2 (SREBF2), is a member of a family of bHLHzip transcription factors that recognize sterol regulatory element 1 (SRE-1). It acts as a transcription activator of cholesterol biosynthesis.
Links
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Statistics
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PSSM-Id: 381492
Aligned: 6 rows
Threshold Bit Score: 160.122
Created: 17-Jan-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative DNAputative dimer
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLHzip mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Comment:Based on the structure evidence that Homo sapiens SREBP1 (1AM9) bHLHzip binds DNA.
  • Citation:PMID 9634703
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #     # ### ## ###   #                 ##                                    
Q12772        326 PKEGERRTTHNIIEKRYRSSINDKIIELKDLVMGtDAKMHKSGVLRKAIDYIKYLQQVNHKLRQENMVLKLANQKNK 402  human
Q6GQ26        286 PKEGERRTTHNIIEKRYRSSINDKIMELKDLVMGtDAKMHKSGVLKKAIDYIKYLQQVNQKLRQENMALKLANQKNK 362  African clawed frog
CAC35016      172 PKEGERRTTHNIIEKRYRSSINDKIIELKDLIMGtDAKMHKSGVLRKAIDYIKYLQQGNHKLRQENMVLKLANQKNK 248  chicken
A3KNA7        316 VKEGERRTTHNIIEKRYRSSINDKILELRDLVLGnDAKMHKSGVLRKAIDYIKYLQQVNHKLRQENLTLKMANQKNK 392  zebrafish
XP_007908491  296 LKEGEKRTTHNIIEKRYRSSINDKIIELKDLVMGsESKMNKSGVLRKAIDYIKYLQQANHKLRQENMALKVATQRSK 372  elephant shark
XP_006820383  306 LVKGEKRSAHNAIERRYRSSINDKIIELKEMVLGrDTKMNKSGILRKAIDYIKFLQNSNHKLKEENMMLKMGLGKSG 382  Saccoglossus kow...

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