2E4Z,3MQ4


Conserved Protein Domain Family
PBP1_mGluR_groupIII

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cd06376: PBP1_mGluR_groupIII 
Click on image for an interactive view with Cn3D
ligand-binding domain of the group III metabotropic glutamate receptor
Ligand-binding domain of the group III metabotropic glutamate receptor, a family which contains mGlu4R, mGluR6R, mGluR7, and mGluR8; all of which inhibit adenylyl cyclase. The metabotropic glutamate receptor is a member of the family C of G-protein-coupled receptors that transduce extracellular signals into G-protein activation and ultimately into intracellular responses. The mGluRs are classified into three groups which comprise eight subtypes.
Statistics
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PSSM-Id: 380599
Aligned: 9 rows
Threshold Bit Score: 828.675
Created: 6-Jun-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
ligand bindingputative dimer
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:2E4Z; Rattus norvegicus mGluR subtype 2I complexed with 2-morpholin-4-ylethanesulfonic acid, contacts at 4A
  • Structure:3MQ4; Rattus norvegicus mGluR subtype 2I complexed with 2 Ly341495, contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                     #                  #  #                                            
2E4Z_A        11 IRIEGDVTLGGLFPVHAKGps----gvPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQ 86   Norway rat
3MQ4_A        11 IRIEGDVTLGGLFPVHAKGps----gvPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQ 86   human
O00222        40 IRVDGDIILGGLFPVHAKGer----gvPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQ 115  human
NP_001073489  54 IKIEGDITLGGLFPVHSRGpa----giPCGEVKKEKGIHRMEAMLYALDQINSDPDLLPNITLGARILDTCSRDTYALEQ 129  zebrafish
NP_001106479  39 IRIEGDITLGGLFPVHSRGlp----gmPCGDIRKENGIHRLEAMLYALDQINSDPDILPNVTLGARILDTCSRDTYALEQ 114  western clawed...
EEN53384      26 IIVDGNITLGGLFPVHSRGsn----gvGCGEVKEEAGIQRMEAMLYAIDKINQDDTLLPGVSLGAHILDTCSSDTHALGE 101  Florida lancelet
O15303        33 VRLAGGLTLGGLFPVHARGaa----grACGQLKKEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQ 108  human
EFX87236       4 HLVLTDHSGGGGAAGSAAGlgggglefPCGAIKEEKGIQRLEAMLYALDLINDDPHILPNITIGAVILDTCSSDTHALDQ 83   common water flea
OCT85749      39 IRLEGDVTLGGLFPVHARGll----gmPCGDIRKENGIHRLEAMLYALDQINSDPDILPYVTLGARILDTCSRDTYALEQ 114  African clawed...
Feature 1                                                   # #                                  
2E4Z_A        87 SLTFVQaliqk----dtsdVRCTNGEPPVFv-kPEKVVGVIGASgSSVSIMVANILRLFQIPQISYASTAPELSDDRRYD 161  Norway rat
3MQ4_A        87 SLTFVQaliqk----dtsdVRCTNGEPPVFv-kPEKVVGVIGASgSSVSIMVANILRLFQIPQISYASTAPELSDDRRYD 161  human
O00222       116 SLTFVQaliek----dasdVKCANGDPPIFt-kPDKISGVIGAAaSSVSIMVANILRLFKIPQISYASTAPELSDNTRYD 190  human
NP_001073489 130 SLTFVQaliqk----dnsdVRCSNGEPPIIp-kPERVVGVIGASaSSVSIMVANVLRLFAIPQISYASTAPELSDNNRYD 204  zebrafish
NP_001106479 115 SLTFVQaliqk----dtsdVRCTNGDPPVFv-kPEKVVGVIGASeSSVSIMVANILRLFQIPQISYGSTAPELSDDRRYD 189  western clawed...
EEN53384     102 ALAFVRsimdr----dvrdAVCKDGAPALKk-rRRPVVGVIGAAsSSVSVDVANILRLFEIPQISYASTSAELSDKSRFD 176  Florida lancelet
O15303       109 ALSFVQalirgrgdgdevgVRCPGGVPPLRpapPERVVAVVGASaSSVSIMVANVLRLFAIPQISYASTAPELSDSTRYD 188  human
EFX87236      84 SMEFVRsymnk----daseYQCESGDAPRYv-pHKPITGVIGASfSTESIMVANILRLFKIPQISYASTSAELSDKSRFE 158  common water flea
OCT85749     115 SLTFVQaliqk----dtsdVRCTNGDPPVFv-kPEKVVGVIGASeSSVSIMVANILRLFQIPQISYGSTAPELSDDRRYD 189  African clawed...
Feature 1                                           ##                                           
2E4Z_A       162 FFSRVVPPDsFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAggLCIAQSVRIpqerkdrtidFDRIIKQ 241  Norway rat
3MQ4_A       162 FFSRVVPPDsFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAggLSIAQSVRIpqerkdrtidFDRIIKQ 241  human
O00222       191 FFSRVVPPDsYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIggVCIAQSQKIprep--rpgeFEKIIKR 268  human
NP_001073489 205 FFSRVVPPDsFQAQAMVDIVKAMGWNYVSTLASEGNYGESGVDAFIQISREAggLCIAQAIKIprep--rpgeFDKIIKR 282  zebrafish
NP_001106479 190 FFSRVVPPDsFQAQAMVDIVKAMGWNYVSTLASEGSYGEKGVESFMQISREAggVCIAQSLKIpyer--ttsdFDKIIKQ 267  western clawed...
EEN53384     177 YFSRVVPPDtYQAQAMVDLAKELGWTYVSTIASEGNYGESGVETFAARARQNg-VCIAASEKIdrha--sdetFEDIIEY 253  Florida lancelet
O15303       189 FFSRVVPPDsYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREAggVCIAQSIKIprep--kpgeFSKVIRR 266  human
EFX87236     159 YFSRVVPPDnFQAQALVEMVRQLGWKYVSTVAVEGDYGEKGIASFVTLAEAAg-ICIAVSEKIlrra--edadYDRIIER 235  common water flea
OCT85749     190 FFSRVVPPDsFQAQAMVDIVKAMGWNYVSTLASEGSYGEKGVESFMQISREAggVCIAQSLKIpyer--ttsdFDKIIKQ 267  African clawed...
Feature 1                                                                                        
2E4Z_A       242 LLDTpNSRAVVIFa-NDEDIKQILAAAKRAdqvGHFLWVGSDSWGSKINPlhqhEDIAEGAITIQPKRATVEGFDAYFTS 320  Norway rat
3MQ4_A       242 LLDTpNSRAVVIFa-NDEDIKQILAAAKRAdqvGHFLWVGSDSWGSKINPlhqhEDIAEGAITIQPKRATVEGFDAYFTS 320  human
O00222       269 LLETpNARAVIMFa-NEDDIRRILEAAKKLnqsGHFLWIGSDSWGSKIAPvyqqEEIAEGAVTILPKRASIDGFDRYFRS 347  human
NP_001073489 283 LMETsNARGVIIFa-NEDDIKRVLEAAKRAnltGHFLFVGSDSWGAKISPilnqEDVAEGAVTILPKRASIEGFDQYFTT 361  zebrafish
NP_001106479 268 LLETsSARAVVLFavDDDDIRQVLSAVKRAdkvGHFHWVGSDTWGAKVGPiiqnEDVAEGAITILPKRATIEGFDAYFTS 347  western clawed...
EEN53384     254 LGKTpKARAVIVFa-DEDDLKKLIAAAKRLgvgSHFLWVGSDSWGTKVTPvegqEEAAEGAITILFKSQTIPGFDRYFTK 332  Florida lancelet
O15303       267 LMETpNARGIIIFa-NEDDIRRVLEAARQAnltGHFLWVGSDSWGAKTSPilslEDVAVGAITILPKRASIDGFDQYFMT 345  human
EFX87236     236 LSQKsSARGVVMFa-DEDETRRMLAATMRLnktGQFLWVGSDSWGAKLHPvrdqEFAAEGAITILPKRSSLAGFDAYFKA 314  common water flea
OCT85749     268 LLETsNARAVVLFavDDDDIRQVLSAVKRAdkvGHFHWVGSDSWGTKTGPisqhEDVAEGAITILPKRATIEGFDAYFTS 347  African clawed...
Feature 1                                                                                        
2E4Z_A       321 RTLe-------------------------NNRRNVWFAEYWEENFNCKLtisgs-----kkedtDRKCTGQERIgkdsnY 370  Norway rat
3MQ4_A       321 RTLe-------------------------NNRRNVWFAEYWEENFNCKLtisgs-----kkedtDRKCTGQERIgkdsnY 370  human
O00222       348 RTLa-------------------------NNRRNVWFAEFWEENFGCKLgshgk------rnshIKKCTGLERIardssY 396  human
NP_001073489 362 RSLe-------------------------NNRRNIWFAEFWEDDFKCKLtrpgi-----rgdggLRKCTGEERIgrdsgY 411  zebrafish
NP_001106479 348 RTLe-------------------------NNRRNVWFAEFWEENFNCKLtitgs-----kkedtDRKCTGQERIgqdslY 397  western clawed...
EEN53384     333 LKPe-------------------------NNRRDVWFEEYWESHFNCRFdnipsn----tggdgLQKCTGKKTIstasgF 383  Florida lancelet
O15303       346 RSLe-------------------------NNRRNIWFAEFWEENFNCKLtssgt-----qsddsTRKCTGEERIgrdstY 395  human
EFX87236     315 LRPktakvanasgngenqyyrnavkgsriYNCRNPWFRQFWEQHFKCRFnssasasgtgqssstLPECKGGDKLt---yY 391  common water flea
OCT85749     348 RTLe-------------------------NNRRNVWFAEFWEENFNCKLtitgs-----kkedtDRKCTGQERIgqdspY 397  African clawed...
Feature 1                                                                                        
2E4Z_A       371 EQEGKVQFVIDAVYAMAHALHHMNKDLCad-yrGVCPEMEqa-gGKKLLKYIRHVNFNGSAgtPVMFNKNGDAPGRYDIF 448  Norway rat
3MQ4_A       371 EQEGKVQFVIDAVYAMAHALHHMNKDLCad-yrGVCPEMEqa-gGKKLLKYIRNVNFNGSAgtPVMFNKNGDAPGRYDIF 448  human
O00222       397 EQEGKVQFVIDAVYSMAYALHNMHKDLCpg-yiGLCPRMSti-dGKELLGYIRAVNFNGSAgtPVTFNENGDAPGRYDIF 474  human
NP_001073489 412 EQEGKVQFVIDAVYAMAHALHSMHIDLCpg-smGVCDKMDpv-dGRMLLTYIRAVNFNGSAgtGVMFNENGDAPGRYDIF 489  zebrafish
NP_001106479 398 EQDERVQFVVDAVYAMAHALHNMNKDLCpg-stGICPEMEha-gGKKLLKYIRNVSFNGSAgtPVMFNKNGDALGRYDLF 475  western clawed...
EEN53384     384 VQEGKVQFVVDSVYAMAYALHDMRNDLCpgttsGLCEEMEhv-nGKQFLEYIRNVTFTGIGgdTVAFNAKGDGPGRYDIF 462  Florida lancelet
O15303       396 EQEGKVQFVIDAVYAIAHALHSMHQALCpg-htGLCPAMEpt-dGRMLLQYIRAVRFNGSAgtPVMFNENGDAPGRYDIF 473  human
EFX87236     392 EQEGLVPFVVDAVYAMAHAVHRMIADVCghdarELCDELKpapsGRNLLKYIRNVNFIGPQgqPVRFNKDGDAYGSYSFY 471  common water flea
OCT85749     398 EQDGRVQFVVDSVYAMAHALHNMNKDLCps-stGICPEMEha-gGKKLLKYIRNVSFNGSAgtPVMFNKNGDALGRYDIF 475  African clawed...
Feature 1                                             
2E4Z_A       449 QYQttnt--tnpgYRLIGQWTD----ELQLNIEDMQW 479  Norway rat
3MQ4_A       449 QYQttnt--snpgYRLIGQWTD----ELQLNIEDMQW 479  human
O00222       475 QYQitnk---steYKVIGHWTN----QLHLKVEDMQW 504  human
NP_001073489 490 QYQlsnt--tnpgYKLIGQWTN----HLRLSAEDMQW 520  zebrafish
NP_001106479 476 QYQitng--stqgYRLIGQWTD----ELQLNIEDMQW 506  western clawed frog
EEN53384     463 QYQnnng---iyqYVPIGTWDDsrhrRLSLTSSLLHW 496  Florida lancelet
O15303       474 QYQatngsassggYQAVGQWAE----TLRLDVEALQW 506  human
EFX87236     472 QYQrhgs---kydYVRIGDWSA----SLVLNMSMLAW 501  common water flea
OCT85749     476 QYQttng--smqgYRLIGQWTD----ELQLNIEDMQW 506  African clawed frog

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