Conserved Protein Domain Family
EFh_CREC_cab45
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cd16225: EFh_CREC_cab45 
EF-hand, calcium binding motif, found in 45 kDa calcium-binding protein (Cab45)
Cab45, also termed stromal cell-derived factor 4 (SDF-4), is a soluble, lumenal Golgi resident low-affinity Ca2+-binding protein that contains six copies of the EF-hand Ca2+-binding motif. It is required for secretory pathway calcium ATPase1 (SPCA1)-dependent Ca2+ import into the trans-Golgi network (TGN) and plays an essential role in Ca2+-dependent secretory cargo sorting at the TGN.
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Statistics
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PSSM-Id: 320023
Aligned: 19 rows
Threshold Bit Score: 269.169
Created: 24-Nov-2014
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:EF-hand motif [structural motif]
Evidence:
  • None
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        ####################   ########                                                 
Q9BRK5        67 LEMDGHLNRGFHQEVFLGKDl--GGFDEDAEprr-srrKLMVIFSKVDVNTDRKISAKEMQRWIMEKTaehfqeameESK 143 human
ELT88564      28 MEQDGHLNRDYHKEVIIGNH---EEFEEGDEeek--ekKLREIFFKVDTDLDTYISQEELEEWIQVKVqehfdestdETE 102 Capitella teleta
EKC18995      53 FEKDGHINKDFHKEVFLGNH---EEIDDEPIqia--eaKLVDIFHKIDKDTDGYLNEGELDSWILDKInehmneameENA 127 Pacific oyster
XP_009049768  38 MEHDGHINKEYHKELFLGDH---EEIESDSKsa---daKMKDIFKKVDLDTDGSLSELEMEDWIKQKMqehfdeaitENE 111 owl limpet
XP_011671669  73 MERNGALNKDFQQELFWGPAh--EEMTDVREeeg--rlRLMEIFKLADRDEDKFLTMDELAAWIEEKTaehyseavsSSR 148 purple sea urchin
XP_002121909  92 FGRDGNLNSNYHKEVFLGEEv--KKFENGEYelkeqknQLIKMFKLIDENGDGSLDEAELSKWVLHKTkehfseakqENE 169 vase tunicate
XP_001633892  18 LERDGDINKDFHHEAFLGKLi--KDGTLTFEnkm-gykKLIEIFHQVDYDKDHLVSKDELSYWIHERIlehveearlRNE 94  starlet sea ane...
KDR09191      66 LERDGDVNINFHKDVIIGDV---KEGPQYEDpk----tLLENIFKNADVSGDGLLSLQELSDWINKKIqehinealrDNF 138 Zootermopsis ne...
NP_495338     35 LEKDGELNDKFRQEMIFSHNldpSDSKQLSE-------SIKEMFKKTDVNDDGFLTAGELKQQIRKNMeehleksknDSE 107 Caenorhabditis ...
KFM70938      74 MERDGHLNKEFRKEVLLGNEs--QSGTQDEQ-------LLISIHKKADTNQDGFLNVEELEIWIMNKVkehfqravrDNF 144 Stegodyphus mim...

Feature 1                                                                                        
Q9BRK5       144 THFRAV-DPDGDGHVSWDEYKVKFLASKghsekevadairln-eelkvdeetqevleNLKDRWYQADsPPADLLLTEEEF 221 human
ELT88564     103 RIFKHL-DSDKDGTVAWEEFHVHFLLAKgvsaeeaekqvsdyyavgsldpdakenliRYKFRWAEADlDPQDNKLTMEEF 181 Capitella teleta
EKC18995     128 AIFKHL-DPDGDGYVEWKEYYKHFLLAKghglnetekyledy-dtdilqdderdklvWYKFKWTDADiKPIDNRLDVEEF 205 Pacific oyster
XP_009049768 112 QIFKHL-DPDGNGKVHWKEYYVHFLLAMdvpeekarkhvidy-diveldsddkedliRYKFRWADADeEPEDNELTKEEF 189 owl limpet
XP_011671669 149 QGFPQV-DTNKDGYLQWDEYREQFFKHRgldeeklkayreg---klsidetleqdyaMYRDRWDRAD-EDNDNSLSVEEF 223 purple sea urchin
XP_002121909 170 QKFKEL-DTDNDGNVTWNEYLTEFLSRKnysrvevaeklrnk-vkievdakvrdevdDVHDKWLQAS-NDGDSNMSVSEF 246 vase tunicate
XP_001633892  95 GLFKSA-DLNKDGSITWLEYRTKLLVGDgnatvspkkyv--------fssgedgglpDEYGHWKKAD-VNQDGKIDVTEF 164 starlet sea ane...
KDR09191     139 GLFDAIdNNPKNGVISWEEYHTYFLRQKgfskeyaenhdkk---hrglnrsikeavmRDRASWSEAA-HSDPDHLTLDEF 214 Zootermopsis ne...
NP_495338    108 IFFDIV-DTNKDGSIVWEEFEPHFSKMHekdhsdselmd--------vhtedphrvdDEKRMFNRSD-ITRDGRLDRMEW 177 Caenorhabditis ...
KFM70938     145 LIFTSL-DKDHNGRVSWEEFHVNFMIEQgfnktyaknhpen---hkhlkrkvkekilLDKAAWSEAA-NSDPDALNIDEF 219 Stegodyphus mim...

Feature 1                                                                                        
Q9BRK5       222 LSFLHPEHsrgmlrfMVKEIVRDLDQDGDKQLSVPEFISLPVGTVenqqgqdi--ddnwvkdRKKEFEELiDSNHDGIVT 299 human
ELT88564     182 ASFRHPEQskdmlerLVKEIMDNLDQDSNDEISLKEFVALPPGEIeyaaqds---dkmwqneREKEFKEVvDLNSDGKIT 258 Capitella teleta
EKC18995     206 FSFRHPEHsvqlienMVLSIINSLDVDKDGKLTLKEFSKPDIMEEdptteke---reeeykvREKEFVSAiDKNKDGVAT 282 Pacific oyster
XP_009049768 190 LSFRHPEQspkslnnMVFSIINALDKNGDNILTVQEFAALPPGEVegedqkdl--drqwqkeRENEFHIAvDIDRDGKAT 267 owl limpet
XP_011671669 224 LAFLHPEHcksmlsmLVEEVLHDLNQNDDTALNLREFLSLPDDAHldlgkaan--ddewvreRKNEFEENiDLDGDGIAT 301 purple sea urchin
XP_002121909 247 LDFQHPETgremleyLVQDFLHDMDVDGDEVLTIQEYISVGSDVDvdtqdd------dwakeRRNEFRNViDQNKDGKVT 320 vase tunicate
XP_001633892 165 LYFQHPEYnpetikkMAEDMLVNFDRNGDKIMTGDEFLALPPGEVdpdqaaa---ekeykedRKREFKLM-DKNGDGVVK 240 starlet sea ane...
KDR09191     215 LSFRHPESshatiiaLVDELLDKFDRDGDEILTEDEFSVLQTEGDgekeget---ltqgedeRRKEFRDViDRNHDGKAD 291 Zootermopsis ne...
NP_495338    178 HIFLHPEYsaqglveIVNDLMGVYDKNNDEVVSQDDFVNGIPGTVdelnpefenmeklekerRLREFNEEiDENSDGKAT 257 Caenorhabditis ...
KFM70938     220 LTFRHPEHshvsllnMVNDIIGSLDNDGDEMLSEQEFVEMPDPDEtnqsla------ewkqqRTREFRDTiDLNHDGRVS 293 Stegodyphus mim...

Feature 1                                                        
Q9BRK5       300 AEELESYMDPMNeynalnEAKQMIAVADENQNHHLEPEEVLKYSEFFT 347 human
ELT88564     259 KDELKVYMDPKNpthsrsEAASLIQMADENNDGKLSLTEVLDNEDLFM 306 Capitella teleta
EKC18995     283 KEEMMEYMNPRNpqqslqEAKNLMSLMDDNKDGKLSVDEIKKHKDIFI 330 Pacific oyster
XP_009049768 268 KEEVHKYIDPRNpiqakmEAKSLISLIDVNKDNKLSIGEIMDRKDIFL 315 owl limpet
XP_011671669 302 FEELEKYMDPRNkqhaesEARHLMGVADMDGDGKLSPREVSNSYFVFL 349 purple sea urchin
XP_002121909 321 KEELKRYLDPMSeamaqqEARQLIGFGDENFDMKLSLKELLENSEYYT 368 vase tunicate
XP_001633892 241 LDELALYLDPRNeqhaanEASYLISVADKNKDAKLSELEMLQNYQLFT 288 starlet sea anemone
KDR09191     292 RKELLMYNDPKNprhaheEAVALLVLSDADHDGSLSLQEILNKMDLFL 339 Zootermopsis nevadensis
NP_495338    258 FRELYDYVDPQNfrlaskEVNDIMMLTDANNDEKLSLEELLERDWLLA 305 Caenorhabditis elegans
KFM70938     294 REELLMYNDPENpvhskmEAKKLIKLADVNKDQLLSLEEVLAKKDSFL 341 Stegodyphus mimosarum

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