Conserved Protein Domain Family
PRK05476

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PRK05476: PRK05476 
S-adenosyl-L-homocysteine hydrolase; Provisional
Statistics
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PSSM-Id: 235488
Aligned: 581 rows
Threshold Bit Score: 308.976
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
269794250   6 FSESPGQYKVRD---------LS--LAEAGRHQIRLAEHEMPGLMSLRAEYGESQPLAGARIAGSIHMTVQTAVLIETLT 74 
189439735  65 TDGHSEEFLCDGtqs---idsITdmRKASGLEAMEYAEQHMPVLRDTMDSLTTRVDFSGIRIAVCLILEPKTAILLRKLK 141
23465683   65 TDEHNEEFLCDGtqsidsitdMR--KAS-GLEAMEYAEQHMPVLRDTMDSLTTRVDFSGIRIAVCLILEPKTAILLRKLK 141
213692812   1 -------MRTAS-----------------GLEAMEYAEQHMPVLRDTMDDLTTRVDFSGIRIAVCLILEPKTAILLRKLK 56 
283455408  66 IDATMPLGDVVDar------eLT------GAEAMRFAQEHMLVLDALMRQMRKDVDFTGIRIAVCLILEPKTAVLLRQLK 133
11498491    1 ---------------------MK--LVRKFARDIEVDE-----------------------LAICIPLEYKSACLIYELS 34 
108804820   1 ---MIRDSIIKD---------PS--LAPEGHRKIAWVAQHAPVLRAIAQRRLSDGSLRGRRVAMAIHLEAKTAYLAILLR 66 
108803081   1 --MRGENSVVKD---------PA--LAPEGHRKIEWAAAHSPVLAAVRERYLKDGTFDGLGVGVALPVEAKTAYLAAVLA 67 
269926589   1 ------MSISPD---------AN--LIKEGERKIEWVAQHSPVLNRLRDTILNDGTFQGKRLALCVHLEAKTAYLATILA 63 
269926590   1 --MISNESIIKD---------PS--LAPSGERKIQWVDQHSPVLNALREKYLNKESIGGLKIGIIVPLEAKTGFLATVLA 67 
269794250  75 ALGAKVRWASCNIFSTQDEAAAAVVVGphgtvedpqGVP-VFAWKGESLEEYWECTEQILlwpadpdagadaPYAGPNMI 153
189439735 142 AAGAIVG-VYCGPDSTDPRVAEQLRRE---------GIT-VESSRDWTAEQAHEAALHLLd------------EIQPDII 198
23465683  142 AAGAIVG-VYCGPDSTDPRVAEQLRRE---------GIT-VESSRDWTAEQAHEAALHLL------------DEIQPDII 198
213692812  57 AAGAIVG-VYCGPDSTDPRVAEQLRRE---------GIT-VESSRAWTAEQAHEAALRLL------------DKIQPNII 113
283455408 134 AAGAIVG-AYCGSEANDERVAAQLRTE---------GIPvAYDPDWTPAQAH----QGALdl---------lDEIQPNII 190
11498491   35 RY-TNVYAAKLDDFSTKPEVVSWLKEK---------GVE-VKMKRDVVNAEYFLDCAAVL----------------SRVA 87 
108804820  67 EAGAEVTVSGSNPLSTQDAVCAALAER---------GVR-VFATHDPSPEEFEGYLMRTIe-------------TAPEIV 123
108803081  68 EAGARVAVAAPLPSVVQDDVAAALAER---------GVA-VFATSEGAPEDADRWMELALea---------aTAGGEAVL 128
269926589  64 DCGAQVVVTGSNPHSTKDDVCAALASR---------GIT-VYAKQDCPREVW---EEHLLn----------tIDTEPEII 120
269926590  68 DAGAEVVVTGTGPAYVQDDVAAALVAR---------GLR-VYAISGVSDDEFRKYLEKVL-------------EFQPDVL 124
269794250 154 LDDGGDASLLVHdglayeragevpadtrpgepnhseetnvvlallrrvlqddpLRWTAIAENILGVTEETTTGVHRLYQL 233
189439735 199 IDDGASFARLAS-----------------------------------------LERPELTANLIGVAEETTSGVRAFQQM 237
23465683  199 IDDGASFARLAS-----------------------------------------LERPELTANLIGVAEETTSGVRAFQQM 237
213692812 114 IDDGASFARLAS-----------------------------------------FERPELTANLIGVAEETTSGVRAFQQM 152
283455408 191 IDDGASFARLAA-----------------------------------------MERPELMGHIIGVAEETTSGIRAFQAM 229
11498491   88 VKSGKERLKVV--------------------------------------------------------ELTKTGEEYLRKM 111
108804820 124 IDDGAELVSRMV-----------------------------------------LHRPDLLQNVAGASEETTTGVIKLRAM 162
108803081 129 IDDRAGLTRIAH-----------------------------------------TTRRGLLPRLRGASEETTSGVVRLRAM 167
269926589 121 IDDGAELVSRLI-----------------------------------------THRPHLASKVIGSSEQTTTGVIKLRAM 159
269926590 125 IDDRAEFVRMLH-----------------------------------------TDYQHLLSKVRGASEQTTSGVTRLLAM 163
269794250 234 AESGTLLFPAINVNDSVTKSKFDNKYGIRHSLPDGINRAT-DVLMGGKVAFVAGYGDVGKGAAEAFRGQGTRVIVSEIDP 312
189439735 238 QEAGALTYPVVAVNDSVLKTGFDNAHGTGETCVTTMQRILgEHAFDGKNVTVIGYGPVGQGFARRIRALGAEVTICDIDP 317
23465683  238 QEAGALTYPVVAVNDSVLKTGFDNAHGTGETCVTTMQRILgEHAFDGKNVTVIGYGPVGQGFARRIRALGAEVTICDIDP 317
213692812 153 QEAGALTYPVVAVNDSVLKTGFDNAHGTGETCVTTMQRILgEHAFDGKNVTVIGYGPVGQGFARRIRALGAEVTICDIDP 232
283455408 230 QDAGALTFPVIAVNDSMLKTGFDNAHGTGETCITTLQRILgSDCFAGSNVSVVGYGPVGRGFAHRVRALGANVTICDTDP 309
11498491  112 ----DVRMKAISLDSSTLKGTGENTHGTAFGLLDALLRL--NVFLPGKKALILGFGRVGRGCARLLKSVGCDVAVWDNDE 185
108804820 163 DEEGVLPFPVLAANDARMKHLFDNRYGTGHSSIASIVSNT-NLFLSGKVVVVMGFGWVGRGLARYADGMGARVVVCEPDP 241
108803081 168 EREGVLELPAIAANDARCKYLFDNRYGTGQSTLAALMQST-NLMLGGKRVVVLGYGWCGKGIARYAAGLGARVTVCEVDP 246
269926589 160 EKDGVLPWPAIAANDAMCKHMFDNRYGTGQSAIGAVLSST-NLLMAGRKVVIIGYGWCGRGLARYADGMGARVIVVEVDP 238
269926590 164 QEQGVLRLPVIAANNAMCKHFFDNRYGTGQSVWTAIMSAT-NLFIAGREVVVIGYGWCGKGLARRAKGLGARVTVVEVDP 242
269794250 313 ICALQAAMDGYQVAQIEDVLD-EADFFITTTGNKDVITADHLSRMKNKAIVGNIGHFDNEIDMAGLAQVpgvTRTEIKPQ 391
189439735 318 VASLKAVFDGFAAQDIDEALP-CADMVVSATGVRHTVTLEHMRAMHEGAALAVIGGIANEIALDEVSDF--------TPQ 388
23465683  318 VASLKAVFDGFAAQDIDEALP-CADMVVSATGVRHTVTLEHMRAMHEGAALAVIGGIANEIALDEVSDF--------TPQ 388
213692812 233 VASLKAVFDGFAAQDIDEALP-CADMVVSATGVRHTVTLEHMRAMHEGAALAVIGGIANEIALDEVSDF--------TPQ 303
283455408 310 VVALQAVFDGFRAYDIDQAIG-ESDIVVSATGVRHTITLQHMRRMKPDAVLSVIGGIANEIALDQIDGF--------HAE 380
11498491  186 TRQIEALYEGFRVEK-----DfTAEVVVTCTGVKGVLGKEELEEISDGSIILNMG---AEMEIEPAGELi--KDYGL--- 252
108804820 242 VKLIEAYAEGYEVMNSLRAAE-VGDVFVTGTGNLKVLRAEHFERMKDGAILANAGHYDHEFDLAALREMa-vAEREARAN 319
108803081 247 VRGLEAYADGFDVLPALRAAE-VGEVFVTATGNRRVLGEEHFARMRDGALLANAGGVDVEIDVGWLRSAa-aRVREARRH 324
269926589 239 VKALEAIADGFRVMNMQEAAR-EGEFFITATGNIDAIRKEHFEVMQDGALIANAGHYEHEINLQDLSSIs-vSVQEARPY 316
269926590 243 VKGLEAWADGFEVHPLEKCAS-YGDIFVTSTGSPHAIDTQHIEQMKDGAILANAGGLDDEINVKGLEAIa-kEKREARRY 320
269794250 392 ----VHEWTFTTGEragrSIIVLSEGRLLNLGNATGHPSFVMSNSFANQVIGQIEIYTKAGTDEayPvAVHRLPKILDEK 467
189439735 389 vnrdTVQLNVPNGP----TLTLIADGDGVNYTVGGGNPIEIMDLSFAVQASAVAYLLEHRGTLD--H-TLIRLDAATDQR 461
23465683  389 vnrdTVQLNVPDGP----TLTLIADGDGVNYTVGGGNPIEIMDLSFAVQASAVAYLLEHRGTLD--H-TLIRLDAATDQR 461
213692812 304 vnrdTAQLIVPDGP----TLTLIADGDGVNYTVGGGNPIEIMDLSFAVQASAVAYLLEHRGTLD--H-TLIRLDAATDQR 376
283455408 381 nkreLRDLAVPDGP----VIRLISEGDGVNYTVGGGNPIEIMDLSFAVQASAVAHLLRHRGTLQ--P-GLQRLGRDIDRH 453
11498491  253 ----VKEYEI-AGK----RYFLVADGYAANLALGSGTPIEVMDRTFSAAILALNHLS--RSDFD----GIIPLPHHIEST 317
108804820 320 ----ITEYELPDGR----RLHVLARGRLVNIAAADGHPVEIMDLTFAVQALAAHHLANHAAEMR--P-GLQPIPQEIDEL 388
108803081 325 ----VEEFVMPDGR----RLRLVGGGMVVNLTAGDGHPVEIMDLTFAIQALCAYRLAREHAAMR--P-GVHLLPREIDDE 393
269926589 317 ----IKEYRLQDGR----RIHVIADGELVNLAAGDGHPVEIIDLTFAVQALSAHYVAKHRDELQ--P-GVYNLPEEIDKN 385
269926590 321 ----ITEYVLPDGR----RIHLLAEGFLVNLVAGDGHPVEIIDMTFAVQALGMRHVALHYDQLG--P-GVHDFPKELDEE 389
269794250 468 VARLHLDALGARLTELSPAQADYLGIDADGPYK 500
189439735 462 IAASALKARGYRASHAVEDNGYNWRLTRFAEND 494
23465683  462 IAASALKARGYRASHAVEDNGYNWRLTRFAEND 494
213692812 377 IAASALKARGYRASHAVEDNGYDWRLTRFAEND 409
283455408 454 IADIALRTRGYRASHAVADNGYDWTLTRFAENE 486
11498491  318 ILEAIMMYK------------------------ 326
108804820 389 VARTKLDTMGVEPERLTGEQLAYLRSWR----- 416
108803081 394 VARLKLGAVGMGVDALTEEQRRFLAGWRE---- 422
269926589 386 IAKTKLETLGIKLEGLTQKQQQYLNSWRTS--- 415
269926590 390 IARLKLKSLGMGVGSLTKEQINYLHSWR----- 417
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