Conserved Protein Domain Family
bHLH_TS_TCF15_paraxis
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cd11470: bHLH_TS_TCF15_paraxis 
basic helix-loop-helix (bHLH) domain found in transcription factor 15 (TCF-15) and similar proteins
TCF-15, also termed Class A basic helix-loop-helix protein 40 (bHLHa40), or paraxis, or protein bHLH-EC2, is a bHLH transcription factor expressed in caudal lateral and paraxial mesoderm dermomyotome and sclerotome fore limb buds during embryo development. It may function as an early transcriptional regulator involved in the patterning of the mesoderm and in lineage determination of cell types derived from the mesoderm.
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Statistics
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PSSM-Id: 381476
Aligned: 5 rows
Threshold Bit Score: 128.277
Created: 19-Sep-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative DNAputative dimer
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Comment:Based on the structure evidence that Mus musculus myoD (1MDY) basic region binds DNA.
  • Citation:PMID 8181063
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                #   # ### #    #                 ####                     
Q12870        66 GPVVVVRQRQAANARERDRTQSVNTAFTALRTLIPTEPVDRKLSKIETVRLASSYIAHLANVLLLG 131 human
P79782        55 GPMVMVKQRQAANARERDRTQSVNTAFTALRTLIPTEPVDRKLSKIETLRLASSYIAHLANVLLLG 120 chicken
AAI70082      56 QQVVVVKQRQAANARERDRTQSVNTAFTALRTLIPTEPVDRKLSKIETLRLASSYIAHLANVLLLG 121 African clawed frog
NP_571047     58 GSVVIVKQRNAANARERDRTQSVNTAFTALRTLIPTEPVDRKLSKIETLRLASSYISHLANVLLIG 123 zebrafish
XP_014352916  57 GGVVVVKQRQAANARERDRTQSVNTAFTALRTLIPTEPVDRKLSKIETLRLASSYISHLANVLLLG 122 coelacanth

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