Conserved Protein Domain Family
7tmA_P2Y4
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cd15374: 7tmA_P2Y4 
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors
P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).
Links
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Statistics
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PSSM-Id: 320496
Aligned: 4 rows
Threshold Bit Score: 459.654
Created: 25-Nov-2008
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:
  • Comment:partly based on the structure of human P2Y1 receptor with bound nucleotide antagonist MRS2500
  • Comment:also based on the structures of some class A family members with bound ligands (peptides or chemicals), agonists, or antagonists
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracellular surface of its receptor.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                            #  ##            ###### #
P51582     36 ILLPVSYAVVFVLGLGLNAPTLWLFIFRLRpwdaTATYMFHLALSDTLYVLSLPTLIYYYAahnHWPFGteiCKFVRFLF 115 human
P79928     44 LLLPVSYSAVFMVGLPLNIAAMWIFIAKMRpwnpTTVYMFNLALSDTLYVLSLPTLVYYYAdknNWPFGevlCKLVRFLF 123 African clawed frog
CAG09809   17 ILLPVSYGLVFVFGFILNATALWLFLKMRPwn-pNTVFLFHLALSDFLYILSLPTLIYYYAnhgHWPFGvaaCKIVRFLF 95  spotted green puff...
AAC60339   42 ILLPISYGIVFVVGLPLNSWAMWIFVSRMRpwnaTTTYMFNLAISDTLYVFSLPTLVYYYAdrnNWPFGkvfCKIVRFLF 121 turkey

Feature 1     #  #                                            # #####             # ###       
P51582    116 YWNLYCSVLFLTCISVHRYLGICHPLRALRWGrpRLAGLLCLAVWLVVAGCLVPNLFFVTtsnkgttVLCHDTTRPEefd 195 human
P79928    124 YANLYSSILFLTCISVHRYRGVCHPITSLRRMnaKHAYVICALVWLSVTLCLVPNLIFVTvspkvknTICHDTTRPEdfa 203 African clawed frog
CAG09809   96 YVNLYCSILFLTCISVYRYVGICHPIKALNLVkpRHSYLVCASVWAVVIVCLVPNLIFVTtsrrdniTLCHDTTSPElfl 175 spotted green puff...
AAC60339  122 YANLYSSILFLTCISVHRYMGICHPIRSLKWVktKHARLICVGVWLVVTICLIPNLIFVTtsskdnsTLCHDTTKPEefd 201 turkey

Feature 1      #  ### ### ##                                                    #  ## ##  #   
P51582    196 hYVHFSSAVMGLLFGVPCLVTLVCYGLMARRLYQPlpgs----aqsSSRLRSLRTIAVVLTVFAVCFVPFHITRTIYYla 271 human
P79928    204 rYVEYSTAIMCLLFGIPCLIIAGCYGLMTRELMKPivsgn-qqtlpSYKKRSIKTIIFVMIAFAICFMPFHITRTLYYya 282 African clawed frog
CAG09809  176 qYVNYCSVVMVFLFGIPFLVIVVCYCLMARTLCRPrvglssrqqgaVSYQKTLKLIIMVLVMFAMCFVPFHVTRTLYYva 255 spotted green puff...
AAC60339  202 hYVHYSSSIMALLFGIPFLVIVVCYCLMAKRLCKRsfpsp-sprvpSYKKRSIKMIIIVLTVFAICFVPFHITRTLYYts 280 turkey

Feature 1                 ## ###  #  ##                     
P51582    272 rlleadCRVLNIVNVVYKVTRPLASANSCLDPVLYLLTGDkYRRQL 317 human
P79928    283 rllgikCYALNVINVTYKVTRPLASANSCIDPILYFLANDrYRRRL 328 African clawed frog
CAG09809  256 rlakpsCDTLNAINFTYKITRPLVCVNSCVDPILYFLAGDsYRSRL 301 spotted green pufferfish
AAC60339  281 ryfqadCQTLNIINFTYKITRPLASINSCLDPILYFMAGDkYRGRL 326 turkey

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