Conserved Protein Domain Family
bHLH-O_HES3
?
cd18933: bHLH-O_HES3 
basic helix-loop-helix-orange (bHLH-O) domain found in transcription factor HES-3 and similar proteins
HES-3, also termed Class B basic helix-loop-helix protein 43 (bHLHb43), or hairy and enhancer of split 3, is a bHLH-O transcription factor expressed in neural stem and progenitor cells that is involved in tissue regeneration. It regulates gene expression, cell growth, and insulin release. HES-3 is one mammalian counterpart of the Hairy and Enhancer of split proteins that play a critical role in many physiological processes including cellular differentiation, cell cycle arrest, apoptosis and self-renewal ability.
Links
?
Statistics
?
PSSM-Id: 381503
Aligned: 6 rows
Threshold Bit Score: 99.2738
Created: 12-Jan-2012
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
 
putative DNAputative dimer
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Comment:Based on the structure evidence that Mus musculus NPAS3 (5SY7)-ARNT complex binds HRE DNA.
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1          # ##   #                       ##                    
Q5TGS1         1 MEKKRRARINVSLEQLKSLLEKHYSHQIRKRKLEKADILELSVKYMRSLQNSLQG 55  human
AAH92924      48 MEKKRRARINKCLNQLKSLLESACSNNIRKRKLEKADILELTVKHLRHLQNTKRG 102 zebrafish
XP_002933888  24 MEKKRRARINVSLEQLKGLLEKNYSQNIRKRKLEKADILELTVKYLKTLQNSIQG 78  western clawed frog
EMP25927      23 MEKKRRARINVSLEQLKALLEKHYSHHIRKRKLEKADILELSVKYMKSLQNSVQV 77  green sea turtle
XP_007900366   9 MEKKRRARINECLLQLKSLLEIQYSNSIRKRKLEKADILELTVKHLRSLQSSGQG 63  elephant shark
XP_018081607  24 MEKKRRARINVSLEQLKGLLEKHYSQNIRKRKLEKADILELTVKYLKTLQSSIHG 78  African clawed frog

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap