Conserved Protein Domain Family
GTSE1_N
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pfam15259: GTSE1_N 
G-2 and S-phase expressed 1
This family is the N-terminus of GTSE1 proteins. GTSE-1 (G2 and S phase-expressed-1) protein is specifically expressed during S and G2 phases of the cell cycle. It is mainly localized to the microtubules and when overexpressed delays the G2 to M transition. the full protein negatively regulates p53 transactivation function, protein levels, and p53-dependent apoptosis. This domain family is found in eukaryotes, and is approximately 140 amino acids in length. There is a conserved FDFD sequence motif.
Links
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Statistics
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PSSM-Id: 464599
Aligned: 25 rows
Threshold Bit Score: 166.728
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_008978516  28 ILLLADEKFDFDLSLSSSSANE----DDEVFFGPVGHKERCIAASLELSDPSAKqpplpASESPFAWSPLAGEKFAEVYK 103
XP_015208149   9 FVLLTDERFDFDISLSPASGNGddenDDEVFVGPVCHKEKCVAAGIKVQVKEKEncqmeQSDECANWSPLTGDKFVEIFK 88 
XP_005163070   9 FVSLAEEKFDFDVSLSPGSSKGdyevEDEVFVGPVSHKEKCISHGV-ETHMKDNissgpSLGEEPSWSPLTGEKFDEICK 87 
XP_011605872   9 LFFLHEEKFDFDMSMSPASSNGd---EDEVFVEPVGRNERCVSVNVktq--------ldGRQLRTSWSPLTGDQLEAVCQ 77 
5_pfamImport   1 LFFLHEEKFDFDISMSPASSNGde-dEDEVFVEPVSHKERCTSTNVetq--------lsDGQLRSSWSPLSGDQLEAVCQ 71 
XP_023182383   8 LCFLQDEKFDFNVSLSPVSSKGeeedDDEVF---VGHTEQCVSTDV------SSqpeegGGDVQAVWTPLTADQLEAVCE 78 
XP_004086315  32 VLFLQDEKFDFDVSLSPASSKDd---EDEVFEGPVEGEESRVSVSK-------AselleGDHVFSNWSPLTGERLDAVCQ 101
XP_040020000   9 VFFLIDEKFDFDVSLSPASSNGd---EDEVFVGPVGHAERCVSANVasl--------asGGGVRTSWSPLNGEQLDAMCQ 77 
XP_005010320  30 IPLLTDEKFDFDLSLSPASGNE-----DEVFVGPLGHKEKCIAVSTEAKRSTEKse--pASDEKLMWSPLTGEKFVEIFK 102
XP_019475928  29 FPLLADEKFDFDLSLSPSSGSE-----DEVFIGSLGHKEKCIAVNIE-AKSAEKkk-vpTSDDKLTWSPLIGDKFVEIFK 101

XP_008978516 104 EAHSLALQIE-----SSGRNQAAQAAKPEDPRSq---GVERFVRESKLKINLFEKDKDMKKSPTSLKRETYYLSDS 171
XP_015208149  89 EAHLLARQFE-------KSIDSTHKKELNGGKNe---VVEKFVEDSKSKINIFNTPKNAALSP--IKRETFCVQDS 152
XP_005163070  88 EAQQLASHIE--------QTITDSAAESSVVSSc---QTETFEDDAATKLNLFSKPAD-ILSP--IKRETFLVQDS 149
XP_011605872  78 EAHKLANQLQsg-erSQSHSEDDKDNEATAAVTt---QPDEFVQDSQAKLHVFEQSNR-VLSP--IKRETFCVQES 146
5_pfamImport  72 EAHRLASQLQgg-erSRSHSEHEDTTSAVMt------QPEEFVQDSGAKLNVFEQSNR-VLSP--IKRETFCVQDS 137
XP_023182383  79 EAHRLASQLQcrephVQKTNTTHTASDVDMNSMa---TTEEFIQDTEVKLGLLDHTAS-SLSP--IKRQTFCVQDS 148
XP_004086315 102 EAHSLVNQLQ------------DGKACGVEDANi---AGEQFLQDSEAKKKVLCSSSG-ALSP--IKRQTFCVQDT 159
XP_040020000  78 EAQRVAGQLQ--------------CASLLVPPSvpdeATGAFSQDAEAQLAAVDRRAS-ALSP--VKRQTFCVQDS 136
XP_005010320 103 EAHLLALQIE-----RGSKTEQDKISQAEEQEKe---IIEKFVEDSKSKLKILRNENI-EQSPRAAKRETYCVWDS 169
XP_019475928 102 EAHLLALQIE-----SGNKSEENKVSQSEGNGNe---TSEQFVEDLKSKMKILKSHHI-EKSPRAVKRETYCVGDS 168
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