Conserved Protein Domain Family
DUF4586

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pfam15239: DUF4586 
Domain of unknown function (DUF4586)
This protein family, refers to a domain of unknown function. The precise role of this protein domain remains to be elucidated. This family of proteins is found in eukaryotes and are typically between 256 and 320 amino acids in length. There is a single completely conserved residue, phenylalanine (F), that may be functionally important. In humans, the protein is found in the position, chromosome 4 open reading frame 47.
Statistics
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PSSM-Id: 464579
Aligned: 35 rows
Threshold Bit Score: 171.421
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q57V66         3 HLSAFGGLFSDPPLVSTDidpkktDPYd-kMDTIPSRYLGKGMSIG------------RCPSGNGPEVFFDK-KFLTLAS 68  Trypanosoma brucei
XP_001566595   3 DTSAYGGLFQDPSYLSSDpdprktDPYd-kKDAIPSRYLGKSMTVGg-----------RVPPGQHPDAYFDK-KFLTLAS 69 
CBZ12597      75 DKSVYGGLFQDPPYLSSDpdpkktDPYd-kKDAIPSRYLGKNMTIGg-----------RVPPGQHPDAYFDK-RFLTLAS 141
Q4E651         3 QLSVYGGLFSDPPLISTDgdpkrtDPYd-kMDTIPSRYLGKGMSIG------------RSGTGQNAEVYFDK-KYLTLAS 68  Trypanosoma cruzi
XP_002508712  24 AGPDKYGSFSNPGSLNVG------VPYt-gKDPLAQGnsrlrg---------vnmkapSAKMGKGNDASFDR--FKPLYQ 85 
XP_003063000   1 MS-NKYGTFSDAGYLAVG------DPYldgKDPLAQssryrg----------lnmkasTRKTGKDNRACFDK--LKPLYA 61 
EEY67841       2 TTPSRDGGFSDLSFISVG------DPYd-----------------------------qKKAKERGLGGDFKP--FLTCPP 44 
A0CLN6        21 SQRERHGLFNQPPPLLIG------DQY-------NDALKSQGKEKGvl--------vnKKLQKKHEPTLFLEpGYTTL-- 77  Paramecium tetr...
XP_004040205  31 ATKQRFALFSQPPSLATG------D------DKQYQKIYHQRDENGkpitearniqstALKRGKAKDAYFSVlGFTTI-- 96 
A0CX61        23 ATVQRFGLFSSPVPLGLG------D------NSYDNKPRPARNEQGkpitsppnmkvtATQSGKIKSSYFSQlGFTTI-- 88  Paramecium tetr...
Q57V66        69 AEqnnnksvgP-----------FEDATTRMHRERREAKKHNISn--KDFLPPSFPKSINGPGGYSGC----FQErpyefi 131 Trypanosoma brucei
XP_001566595  70 SEqngg-------------kpvgYDENKWCTTAKK-QTKKPISd--KEFRYSSYPERSTGPGSYYGC----FQSrpyeym 129
CBZ12597     142 SEqngg-------------kpvdYDESKQRTAASRTNTKNAISd--KEFCYSSYPEKSTGPGSYYGC----FQNrpyeym 202
Q4E651        69 PEqngnkdlgA-----------FEDADTRMRREAMESKKKNISe--KVFLLPSYPKWSDGPGSYSGC----FQDrpypfi 131 Trypanosoma cruzi
XP_002508712  86 KE--------P-----------FQVSAAEKREARAKAEDGRIQ---GPLVPAGMPKKSSGLGGYGGTlgepFENedgepy 143
XP_003063000  62 NE--------K-----------YALTNEERAARRETEKAGKVTd--KPFKPTSLTKHACGLGGYGGCiggkHESvpggdv 120
EEY67841      45 KKgqlaatfgPgfpkydplggeYAEQYKLEARRRLENTKQFVKp--MGFSYSNPSQNHTGSGDYYGAfg-kYERdeddik 121
A0CLN6        78 ND--------P-----------YKDQFKAKQIYDKERELAIKNp--NCFKPNDHVKSIKHSE---------FEHmkefnd 127 Paramecium tetr...
XP_004040205  97 GD--------K-----------YIDPDSINRQYELEKKKKIKQd--QVFKPPSGYKTIINSA---------FKHenedvy 146
A0CX61        89 GD--------K-----------YIDPERKIRIQELEEKKKYANddkKNFVPPSGYKELVGGV---------YNHeadyei 140 Paramecium tetr...
Q57V66       132 mpgeeggpkskkskrkkkassSEEDSKGKELLPNIKTNPSKKGT-YGYVGILLDNP---------KYNddwrkehEKLEA 201 Trypanosoma brucei
XP_001566595 130 tepwd------dgkskkrraaKPKEEEEPTHLPNIKTNPAKKGT-YGYAGLLLSNP---------IYNdnwkdehAAAEA 193
CBZ12597     203 tepwd-----dgkskkkkrapKPKEEE-PTHLPNIKTNPAKKGT-YGYPGLLLSNP---------SYNddwkkdyAAAEA 266
Q4E651       132 lpgend----kksrrrkkaavTEVTDKNKSSLPNIKTNRTKKGT-YGVPGTLLDNP---------KYNdnwrqemEKLDA 197 Trypanosoma cruzi
XP_002508712 144 fgwg-------tadgeppkglMKGDPSTQPKPRNIVTGPGKKGG-YGMRGYTLGEKksaggsageYKYvat--dyDAERK 213
XP_003063000 121 d--------------pndeklMKGDPRLDEKPRQITTCPGKKGS-YGTRGTTLGGPkghg-vageYSYkgd--eyDAERK 182
EEY67841     122 ka------------aeenaapKPNPKDKQFERKNVLTNPGRRGT-FGYAGTLIGGS---------LTAmda--dfGSERR 177
A0CLN6       128 ----------------kvfntRTPKGDVRTQARNFLTNPAKKGLgRTTTNNLFGQ----------IEYipd--pyDRQEE 179 Paramecium tetr...
XP_004040205 147 ----------------nkknyRDADGKVLTQSKNITTNPSSK---------LQSKH---------YPHlpd--qyERQRQ 190
A0CX61       141 p--------------kgpnnhKGGDGRVKIGPKNVTTNPGSS---------SLGHF---------PKHekd--eyNRYRQ 186 Paramecium tetr...
Q57V66       202 AEAKK-RKKLAPPKPLG-PLFRTPGV--IHDYLDElpa-----------------------tgvSGVY--HFEPADEkps 252 Trypanosoma brucei
XP_001566595 194 ERASKeRKQGPAPKALG-PPFHIPGV--SHSYIDEmpn-----------------------tgvSGVYaaYEAPADSaat 247
CBZ12597     267 NRARReRKQGPAPKALG-PPFHIPGV--SHSYIDEmpn-----------------------tgvSAVYaaYEAPADSaae 320
Q4E651       198 LRAKR-EKNVPQPKPMG-SPFKTPGV--THDFLDElha-----------------------tgvSAVY--HYEPVEEksp 248 Trypanosoma cruzi
XP_002508712 214 ADAA--RAAHGKKLMAGkPDWKPTAPgkRGGPGVTgktlagpk-------------nlggvcgeYRYKpeGPDPKFVpep 278
XP_003063000 183 ANAA--REREGKKKMQG-SAWAPARApkKGGYGTRgttiggpk--------------gagvvgeYSYKeeGPELPEPkgs 245
EEY67841     178 ATKI--LEAKHKAAIGDrKPFKSTTE--GVDFFDShehvaasrvmgwddqclakppgaqelmnpKERAaaRALTYKV--- 250
A0CLN6       180 LDRQD-RIKHRSKFLPGtTRFITTSH--GNRPFTAdgilldga-------------gylsakkrPLYKgaP--------- 234 Paramecium tetr...
XP_004040205 191 LRIQ--EMKKHQELLGEkAAFRSTVF--GRRNFFNdkktfgee-------------glnlkkrpQTN----IKFNIInh- 248
A0CX61       187 FERE--KIFNEQKMLKDkQPFKSTIY--TTDNFSTdkqifget-------------nlpkptqvKEFKpnIMKHEAP--- 246 Paramecium tetr...
Q57V66       253 krkrKNKQEAAGPTFVqeramtfvwtrSGNEGNIDPFPNTWIDVAALeeeekkkn---rrrrrakAKDTYVPGPPKGA-- 327 Trypanosoma brucei
XP_001566595 248 knrkAKKETKAVPTLVherafcgyanrIGEQGCLNPFPNVWVHPDEMqlsksa---------qrkqaqEEAGRPPKGA-- 316
CBZ12597     321 -krkAKREAAAAPTLVherafygsanrSGEPGCLNPFPNLWVHPDETqpskia------lrkqaqKEKEEAARQPKRT-- 391
Q4E651       249 krkgRVKSPAAVAVFTqerpmsfkrtkSGQEGCIADFPNTWIDPDALerernkg-----kkknrkPKPEYVPSPPKGA-- 321 Trypanosoma cruzi
XP_002508712 279 padyPWAPPKPNK------------------GPMNPFPEHMADPEELq-----------------KWKERRREKEGRAki 323
XP_003063000 246 piekQWRPSHPPK--------------RGYNATLQRFPKHMADPAELk-----------------IAAAREKMEADAEli 294
EEY67841     251 -----WKPNHPIK--------------IGEEGTFEKFPERLPEPYDEaivnramlpnrrnpvkiaTKDLPSSLRERRA-- 309
A0CLN6       235 -----FRPANQNK--------------NGFQGTFEVL-QYMEEGVPDp----------------kTKQNTFQKLSATQty 278 Paramecium tetr...
XP_004040205 249 --daPFKPSNPNKRVFiyiikkificyKGWNGTLSKFPEYKPNG---------------------EKQAKRQFMI-KE-- 302
A0CX61       247 -----FKPSNPTK--------------SGETGCLSKYPQYKGDP---------------------LKPTQRIDFV-KG-- 283 Paramecium tetr...
Q57V66       328 TGVWKP--N-----TFECTSVVQSCLR 347 Trypanosoma brucei
XP_001566595 317 -GVWRP--N-----SFEKTSVVSSCLR 335
CBZ12597     392 -EVWRP--N-----SFGKTSVVSSCLR 410
Q4E651       322 SGIWKP--N-----SFPEASVVQSCLR 341 Trypanosoma cruzi
XP_002508712 324 TKAWRP--Ggg-gkSGATKSVLRMNTR 347
XP_003063000 295 EKPFVP--PftgckSQATKSVVKMNLG 319
EEY67841     310 ---FKP--Ggg-pkTKLTRGTCLLGIS 330
A0CLN6       279 ENPWRPnsNgtfarPCPSVS---QQLR 302 Paramecium tetraurelia
XP_004040205 303 KDPFKPkyCgeltrPTPTISCHPLNIR 329
A0CX61       284 KDPFKPnhLmemvrPTPSISCFPHNLK 310 Paramecium tetraurelia
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