Conserved Protein Domain Family
Use1

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pfam09753: Use1 
Membrane fusion protein Use1
This entry is of a family of proteins all approximately 300 residues in length. The proteins have a single C-terminal trans-membrane domain and a SNARE [soluble NSF (N-ethylmaleimide-sensitive fusion protein) attachment protein receptor] domain of approximately 60 residues. The SNARE domains are essential for membrane fusion and are conserved from yeasts to humans. Use1 is one of the three protein subunits that make up the SNARE complex and it is specifically required for Golgi-endoplasmic reticulum retrograde transport.
Statistics
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PSSM-Id: 462882
Aligned: 31 rows
Threshold Bit Score: 208.333
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EDO37586       5 RMEINLQRLLVRCEAMAGDYQEKkeclNWRLEKYVCALQNNANELSKSASK-----PSQDAMSDYTKRVEFLKGLVETEK 79 
CBI17875       5 RTEVNLRRLLAAAPQQQn---------QAKLIHYVATLREQLEQLTEERTLeglprVSKPKVNEYSEKIEAIASKIGSPS 75 
XP_002324665   5 KTEINLRRLLSSAPQQQn---------QAKLVHYIATLREQLEQLAEERTAdelprVSKAVLNDYSEKIEAIASKLVNSL 75 
XP_006595567   5 KTEVNLRRLLAAAPQQQn---------QAKLVHYVATLREQLEQLAEERTLeglprISKAMLNDYSEKIEAIASKLVNHV 75 
Q6NKR3         6 KTEINLRRLLSAAPNQQn---------QSKLMHYVATLREQLEQLSEEKTPeglprVTKAKVNEYYEKIEAVASKIASQE 76  thale cress
XP_004233203   5 KTEVNLKRLLVTAPQQQn---------QAKLIHYVATLRELLEQLADERNSdglprVSKAKVNEYAENIETVAAKLAVPM 75 
XP_009411799  27 KTEINLRRLLDAAPRQKn---------QTKLIHYVTTLREQLEQLGAETTPqgapsIPKAKLNEYSERIEALAAKLAAPL 97 
CTP80817       6 ADEVNFQHLLGRTERLCAESISFn---IIKLNAALEEMEELYDRLQKNRN------IDSEVLKHYGEDLQTLRLQIEAEQ 76 
EFO15290       7 ADEVNFQQLLDLSERLLTDDISPn---MPKLHAALKEMEELYDRLQGNRN------IDDDVLKYYGRDLQTLRLQIEREQ 77 
Q9N598         6 ENELKFLRLLERTKRLTKEDMSAn---VWKVSAATKILNKMIYTLQNDE-------TTNDILHEYRQEVLQLKLLAEAES 75  Caenorhabditis ...
EDO37586      80 AKSTSDKAVTSHHLSRSsahasl-----------lsdrppADRVQELHLKTKSRLDKEMRDELLRTGKTSVTIYtpifdh 148
CBI17875      76 SNvqvsqepfsgtsg-------------kegtskteeedhMPLSPGLRRRFVPASKFEDRSHDTIKAD-ASGPV------ 135
XP_002324665  76 PEieapqetfagds--------------gkespkadggdqIAPSPGLRRRFAPVSNFEDKTRDSIKAD-ASAPV------ 134
XP_006595567  76 IDtqvpgkdfernfv-------------kekhseieekkqILLSSGLRRRPVPASSTEDRAHEPAETD-HTSPI------ 135
Q6NKR3        77 PEtevsdepfakdst-------------sgsspkiedeprSPTSPQLRRRIVPASS-KEQSFDAADAD-SSKPI------ 135 thale cress
XP_004233203  76 SDvhtpeepvaess---------------ssgtpkaeesvnSASEGLRRRFGVHSNNEERSRDTIDSDQSSAAV------ 134
XP_009411799  98 AEheeatheakee----------------gpssteqtvnyTSSLPGLRRRPTAKMETKESSHDAKEKD-SAMPV------ 154
CTP80817      77 KRsapiideqdlpad-----------------seittedstensVLMKAKKKAAYQANLRMQLFDGPERSSSL------- 132
EFO15290      78 KRpaiindeqdltanf-----------giaaegpneskgpSESNAFMEAKKKAAHQAELRMQLLGGPERSSSL------- 139
Q9N598        76 KSSAEERLKVIEKIPRVfpdvqvtvadskndneaesydfeKESAAGLRATQRSIYRSDLRKQLLSSNKHR---------- 145 Caenorhabditis ...
EDO37586     149 cknlpgntdneGKEESIDAVLQYHQNMQEKIAEEMVLMAQNMKHTSMMAQNIIHKDKQVLEASTRLADCNLSKLKHEADR 228
CBI17875     136 -----------KLDAAAQAHIEKHRKLQEDLTDEMVGLAKQLKQSSLLMSQSIQNTEKILDSTEKAVEHSLASTGHVNTR 204
XP_002324665 135 -----------KLDAAAQAHIEKHRKLQDDLTDEMVGLAQQLKESSLLMSQSLQNTEKILDSTEQAVEQSLASTGHANVR 203
XP_006595567 136 -----------KLDATAHAHIEKHRKLQEDLTDEMVVLAKQLKESSLTMSQSLQNTEKILDSTEKAIEHSLASTGRANVR 204
Q6NKR3       136 -----------KLDTAAQAHIDKHRKLQEDLTDEMVVLARQLKERSQAISQSVQNTEKILDSTEEAIEQSLASTGHATTR 204 thale cress
XP_004233203 135 -----------KLDDAARTHIEKHRKLQEDLTDEMVVLARQLKESSLMMNQSIKNTEKILDSTEKAVEHSLASTGHATSR 203
XP_009411799 155 -----------KLDASALDHIEKHRKLQEDLTDDLVALARQLKEGSLLINRSVQDTEKILDSTENAVEHSLASTSRASKR 223
CTP80817     133 -----------DPNLDMEQIARREAEKQENLMDELFGMVRLMKQTYSTASSVIKEDNATLSRLQKATNSHKGSLLRESKR 201
EFO15290     140 -----------DLDLDTEQIAKREAEKQENLMGELFGMVRLMKQTYSTASAVIKEDNATLSRLHQATNNHKGSLLRESKR 208
Q9N598       146 -----------AQDTSEDQEFMKNELVEEELANSLATMARSFKTMMSAAGDVIKEDTERAILMAKEVDDNKTALGIQSER 214 Caenorhabditis ...
EDO37586     229 LEEi--ANRRCSLWMWIALSLVMAVFIMTILFIKMF 262
CBI17875     205 AMDiysNSFKTTCFTWIMIFVMTCIFIMVVLLIRVT 240
XP_002324665 204 TMDiysKTSKTTCFTWLLMFLMTCIFIMVVLLIRVT 239
XP_006595567 205 ATAiysESSKTSCLTWLVMFVMTCVFVMVILLIRVT 240
Q6NKR3       205 ATKiysQSSKTSCFQWLLIFAMICVFIMVVLLIRVT 240 thale cress
XP_004233203 204 AMDvysRSFKTTCVQWLLIFVMTLIFVMVVLLIRVT 239
XP_009411799 224 AIEvysESFKTTCFTWLVIFIMICVFIMVVLLIRIT 259
CTP80817     202 LEEr-aYRSWCDCLYIIGICAVIMSFIAMVIVMRFF 236
EFO15290     209 LEEr-aYRSWCDCLYVLGVCAIVMSFIAMVIIMRVF 243
Q9N598       215 VERh-aYKCGYDCFKVMLIVLIFMSFVSMVLMMKIF 249 Caenorhabditis elegans
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