2CRB


Conserved Protein Domain Family
NRBF2_MIT
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pfam17169: NRBF2_MIT 
MIT domain of nuclear receptor-binding factor 2
This MIT domain is the microtubule interaction and trafficking of nuclear receptor-binding factor 2 - NRBF2 - in higher eukaryotes. It is a coiled-coil region at the N-terminus of pfam08961. NRBF2 plays an essential role in autophagy, the cellular pathway that degrades long-lived proteins and other cytoplasmic contents through lysosomes. NRBF2 binds Atg14L - a Beclin-binding protein - directly via the MIT domain and enhances Atg14L-linked Vps34 kinase (a class III phosphatidylinositol-3 kinase) activity and autophagy induction.
Links
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Statistics
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PSSM-Id: 465368
Aligned: 5 rows
Threshold Bit Score: 130.977
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2CRB_A         8 MEGPLNLAHQQSRRADRLLAAGKYEEAISCHRKATTYLSEAMKLTESEQAHLSLELQRDSHMKQLLLIQERWKRAKREER 87 
XP_005339874   4 MEAPLNLAHQQSRRADRLLAAGKYEEAISCHKKAAAYLSDAMKLTKSEQAHLSLELQRDSHMKQLLLIQERWKRAKREER 83 
NP_001186462  12 MEGPLNLAHQQSRKADRLLAAGKYEEAISCHRKAAAYLTEAMKLTQSEQAQLSLELQRDSHMKQLLLIQERWKRAKREEK 91 
XP_005997767   4 MESPLNLAHQQNRKAERLLAAGKYEEAIACHTKAAECLTEAMRLTKSEQAQLSLELQRESHIKQQRLIQEKWKRARRDER 83 
XP_011228560   4 MEGPLNLAHQQSRRADRLLAAGKFEEAISCHKKASAYLSEAMKLTQSEQAHLSLELQRESHAKQLLVIQERWTRAKREER 83 

2CRB_A        88 LKA 90 
XP_005339874  84 SKA 86 
NP_001186462  92 MKA 94 
XP_005997767  84 QRA 86 
XP_011228560  84 LKA 86
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