2CL3


Conserved Protein Domain Family
NUDIX_2

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pfam13869: NUDIX_2 
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Nucleotide hydrolase
Nudix hydrolases are found in all classes of organizm and hydrolyse a wide range of organic pyrophosphates, including nucleoside di- and triphosphates, di-nucleoside and diphospho-inositol polyphosphates, nucleotide sugars and RNA caps, with varying degrees of substrate specificity.
Statistics
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PSSM-Id: 433540
Aligned: 18 rows
Threshold Bit Score: 236.792
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2CL3_A                    38 RTINLYPL-TNYTFGTK----EPLYE-KD---SSVAARFQRMREEFDKIGM-RRTVEGVLIVHEHRLPHVLLLQ-LGTT- 105
WGS:AAFB:cds.EHI_077110A  57 PLLKIYPI-ENYQIDKK----EKLDKlKH---QTFGYQMDQLKISVEKNHVpRTSVYGVILVHKNNFPHLLVLQ-SNLS- 126
XP_001611850              16 PDWLVYPE-DSYSFRDD----SAPIG-QGllfRTPESLLCKRIRAYNQNGL-RITVYGLILCHRNGFPCILVLR-DTSG- 86 
XP_002140304              29 PTWLIYPL-ENYGIRVDdnpsENLME-DS---IANMNGFNKKVDSFLRDGI-GRSVAALILTHRYLCPHVVLLQ-SDLTs 101
CAQ38053                  39 GEWLVYPQ-ANYEFNIV----EKLKS-KF---IMDTDKIKKRINAYNQDGI-RNSALAIILCHRYEYPHLLLLQnIESQ- 107
Q55E68                     4 KTLTLYNFnTSYSFGKE----E-KKE-KE---QSLTSKLARLKDSYEKEGL-RKAVEGIIIIHDHGHPHILLLQ-DN-N- 70  Dic...
XP_002508304              18 RAIHVYPV-SNYTFGSK----AAKAD-KD---ATVAEAMIRYKDKYEKEGM-RRTVEAILLVNQHDHPHVLLLQ-RTMAg 86 
EFC41954                   5 KVVDIYDY-TFIKWTKK----NPQVE-KD---KSVPERLKRLENNYLTHGM-KRTVEAAIAVNIHGHPHIMLLR-IGNSq 73 
Q94AF0                    27 LMVDLYPL-SSYYFGSK----EALRV-KD---EIISDRVIRLKSNYAAHGL-RTCVEAVLLVELFKHPHVLLLQ-YRNS- 94  tha...
XP_002514092              21 FVLDIYPL-SRYYFGSK----DPLPF-RD---ETLVDRVQRMKSNYLAHGL-RTCVEAVILVELFKHPHLLLLQ-IKNS- 88 
2CL3_A                   106 ---F-----FKLPGGELNPGEDE-VEGLKRLMTEILG--------------RQd--gV--------LQDWVIDDCIGNWW 152
WGS:AAFB:cds.EHI_077110A 127 ---MdlkdeIHLVGGRLKIGEDDpVEGLKRKLRKKMS--------------ME----Y--------ITHYEIGELLGTFY 177
XP_001611850              87 ---N-----IGLLGGKCKSFENP-REVLKLKLARFVS--------------TSrk-gVhqlnvranVDTIIVGEFMGEFW 142
XP_002140304             102 ---E-----WMLPNCLYRAWENP-RTVLVSFLKSLFF--------------TDsnstE--------NNTAEVGEYLGSWW 150
CAQ38053                 108 ---T-----YHLLSGKYKSWEKP-REVLKKKLQKYVNqirdmhfgtshfntEEk--eT--------EDPIEIGEFLGEWW 168
Q55E68                    71 ---Y-----FKLPGGKLKPGENE-IDGLIRKLTKKLS--------------PTgtpvS--------DAPWEIGDHVSTWW 119 Dic...
XP_002508304              87 ggvE-----YKLPGGRLRHGEGE-VAGLQRKLHNKLS--------------PSe--qSl------rIEHWECGDCVARWF 138
EFC41954                  74 k-gF-----HKLPGGRCRRDETE-EECLKRKLTKRLA--------------PEdpneI--------MPEWIVHGVVSVWY 124
Q94AF0                    95 ---I-----FKLPGGRLRPGESD-IEGLKRKLASKLS--------------VNe--nVg-------VSGYEVGECIGMWW 142 tha...
XP_002514092              89 ---I-----FKLPGGRIRPGESD-IGGLKRKLSRKLS--------------NNq---D--------QTDWEVGECLGMWW 134
2CL3_A                   153 RPNFEPPQYPYIPAHITKPKEHKKLFLVQLQEKALFAVPKNYKLVAAPLFELYDnaPGYGPIISSLPQLLSRF 225
WGS:AAFB:cds.EHI_077110A 178 RIEYDKNLYPYIPVHVSQVKEIINIYMIHLVEKCDFKIFDTDKLSSIPLFALHNnfEKYNITLCSIPTLVSRY 250
XP_001611850             143 RAEYDSDVLPYLPLHINRPREKILIYQVTLREQCSFIAPGDMHIEPMALHEFYC--AEQSVAISALPHLLTRF 213
XP_002140304             151 RTEFNYSPLPYLPPHSTRPKELIRIYQVLLPPKVLFKLPKYHVLKSLPLFDLDPn--iFGIACGGIPQLISRF 221
CAQ38053                 169 KTQFNSVYLPYLPAHITRPKEYIRLYQVTLTSRCIFHLPPGFTLKALPLFDLST----CGVAIGGLTSVLSRF 237
Q55E68                   120 RPNFEPSLFPYIPSHITKPKECKKLFVVTLPEKCKFAVSNNLSLIAVSLYEIYNnsQRYGAVISSIPALISRY 192 Dictyostel...
XP_002508304             139 RPAFEPNYYPYLPAHVTKPKESRTVYIAQLPERCKFCVPKNLKLLAVPLFEMYAneAKYGAVAASVPYLISRF 211
EFC41954                 125 RPNFENSFYPYLPAHITKPKERKLIYLVTIPE-CTIAYPRNYDFIPMPFFDLYEnsKKFGSIISSLPQVISKF 196
Q94AF0                   143 RPNFETLMYPFLPPNIKHPKECTKLFLVRLPVHQQFVVPKNFKLLAVPLCQLHEneKTYGPIMSQIPKLLSKF 215 thale cress
XP_002514092             135 RPDFETLLYPYLPPNLKTPKECTKLFLVRLPTSCKFIVPKNLKLLAVPLSQIHDnhKTYGGIISGVPQLLSKY 207
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