4NC6


Conserved Protein Domain Family
RabGAP-TBC

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pfam00566: RabGAP-TBC 
Rab-GTPase-TBC domain
Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.
Statistics
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PSSM-Id: 459855
Aligned: 70 rows
Threshold Bit Score: 73.0572
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4NC6_A        34 EALRGEVWQllagchnndhlve-------------------kyrilitkespqdSAIT-RDINRTFP----AHDYFKDtg 89 
A0BI92       170 EDFNL--WQtiendtkrtrqregffhien-----qeaslfedvkklyiqdqvaiLRLKrVDIEYNYD------------- 229 Paramecium tetr...
O94661        38 KSLRKSVWVslcglscrhrmec-------------------lsrstsqssyadqNQVH-LDSERSFFq--yKLNPFLL-- 93  Schizosaccharom...
Q7S8L1        61 DELRQQAWPillglppkpfdedsss--------------ssyssweslpphqdeDQVQ-LDVDRSFTyypsHTSDSAR-- 123 Neurospora crassa
Q18386       450 PTQRADVWCtlldinetkwrdy--------------------lnldvlashssdRQLE-VDIPRCHQ----YDSYMTT-- 502 Caenorhabditis ...
Q6CII2        36 QRTRSHVWSilsraslekctqey-----------------lrlvqlgappsnwiSKIK-NDTFRTLS----TDEKFRN-- 91  Kluyveromyces l...
Q6BQX2       139 FQLRSTIWKklflisqgnvipetsr--------------lvfdnfqhsysleisKQIS-KDLSRTFP----LVEFFKN-- 197 Debaryomyces ha...
XP_001324732  27 DAVRAKVWMhllnvsdsshhfegqq-------------vvertkyykslrpttfPYIK-NAVNTVIH-----HMALTE-- 85 
XP_002041664  34 EALRPDVWQvcldvrhksdqm---------------------slfneiydlpfqSQLR-EDCQRHVDr--mGNDEEDK-- 87 
Q54NT3        33 DKVRPEVWKyllgisktdkseeervkkqqqqeykeidkndsettkkirahlkryQNFN-RDKSDTRI-----KIDWQS-- 104 Dictyostelium d...
4NC6_A        90 GDGQDSLYKICKAYSVYDE---EIG-------YC--QGQSFLAAVLLl----HM-PEEQ-------AFSVLVKIMf-dYG 144
A0BI92       230 -----VLTRILFIYTKLNG---Q---------YI--QGMNELVAILYycfvnDD-STLLrsqaevdTFFCFTILL---SQ 286 Paramecium tetr...
O94661        94 RKHRSQLTKLLSVVFKHYP---ELC-------YY--QGLHDIAQILLl----TL-PFSH-------ALPLMEHLVf--YR 147 Schizosaccharom...
Q7S8L1       124 SLQKSLLSSLILSVLRRHP---YLH-------YF--QGYHDISQVLLl----VL-PAHL-------RSPALARLSa--LR 177 Neurospora crassa
Q18386       503 PAIQESLRKVLKGWQIVTEs-qHFV-------YW--QGCDSLATPFLl---aNMsKPHV-------AFACFKEFTy--RY 560 Caenorhabditis ...
Q6CII2        92 KVTESQLIRVLSCFAWDVLdsnQTHelpglspYV--QGMNVLLAPFLy----VC-PTEPi------AYKLFHSLCf--QM 156 Kluyveromyces l...
Q6BQX2       198 EETINNLSTILNVYANYDV---ELG-------YC--QGLLFLVGVLYyh--fKS-DSTL-------TFHALVTIMesePE 255 Debaryomyces ha...
XP_001324732  86 ENISAGLSNILCNYFSCNP---NVH-------FN--MGIVSLTVPLFia--sEN-DEVS-------SFFLLTNLL----- 138
XP_002041664  88 VSVVSDLESIITFYCKNRN----LQ-------YEpdNGWIELLLPLFa---lKL-NRSD-------TFNLFESIRd--TY 143
Q54NT3       105 VEIRNKIENIIISYNNYNN---DIE-------YS--FGMLAILGPFIs----TL-QTESd------IFFCFAAMM---KK 158 Dictyostelium d...
4NC6_A       145 LRELFKQNFe------dLHCKFY---QLERLMQEYIPDLYNHFLDISLea-hmYASQWFLTLFT-AKFPL-YMVFHIIDl 212
A0BI92       287 FRYNFFSKDeasicngfIQNKIR---VVQEIIKKHDFRLYDHMLKIKIdp-klFMSKWFMTVFT-KEFKL-YDTIILWD- 359 Paramecium tetr...
O94661       148 LRDFMLPT---------LDGTVKqlqLILAVIKARDPTLYEYL--IKAdiqcyFALSWLITWFA-HDVSDiSVVCRLFD- 214 Schizosaccharom...
Q7S8L1       178 IRDFMLPN---------LQAAIAqlrLIPDILRVSDPPLWRHL----SgtepfFALSGTITMYA-HDITTlGEITRLFD- 242 Neurospora crassa
Q18386       561 CHKFYLKDNse-----vIKEYLG---IFYHLVAYTDPVLYKHLKINGFda-elFAIPWFLTCFA-HELPL-SKLVLLWDe 629 Caenorhabditis ...
Q6CII2       157 IPTYLNQSLsg----vhVAAK-----LLDKCLKIIDPKLSKFLTDNLLta-eiFGIPSILTLSA-CNKPL-DQVIKLWD- 223 Kluyveromyces l...
Q6BQX2       256 LHDIFTSTTms----ytLNKWKF---EFSAILREIDNELYEHLNK-FVdm-qvFLYQWWLSFISsHTPDL-SIVNRVMDf 325 Debaryomyces ha...
XP_001324732 139 -DRWYFQNSdd----ihIKQAAK----LAKYISIFYPDLANHFSSEALdm-seIFIHWFQFYHS-TALPI-QSLLRLWD- 205
XP_002041664 144 IPKGCRPK----------GNVFH---VFRLLLLYHDPELCTLLDTKKItp-dlYSLTWFQSLFA-SCSSL-SVIIAMWD- 206
Q54NT3       159 IEENLQNESlt----lkLSRFIM---YFRSVL----PELFSHFEEEEIns-ndWATSWIQNYLS-CELPI-ECTLRLWD- 223 Dictyostelium d...
4NC6_A       213 LLC----EGi-----SV-IFN-VALG-LL-KTSKDDLL 237
A0BI92       360 HILcel-------ddKNeLLNyIALA-II-HWLREDLL 388 Paramecium tetraurelia
O94661       215 FFIs-----------SHpLTV-VYTCaQVvLDNRTSII 240 Schizosaccharomyces pombe 972h-
Q7S8L1       243 VLLa-----------REpVFS-VYMFaAIvRSRREELF 268 Neurospora crassa
Q18386       630 TMM----HGn-----AF-PLM-IALA-ML-NRLRDKLL 654 Caenorhabditis elegans
Q6CII2       224 FMFay--------gfHMnILF-IVAQlVI---NRQAIM 249 Kluyveromyces lactis
Q6BQX2       326 CLL----QGw-----KTgMFK-ISLG-LL-LVNKPILM 351 Debaryomyces hansenii
XP_001324732 206 TYLsldaEHl-----RKtTLF-VSLA-LV-ERLMPKIL 235
XP_002041664 207 LYF----QNa----dPFmVFF-LALI-IL-INGREQIL 233
Q54NT3       224 TYL----SGrlgldlHV---Y-VCLA-IL-TNFSEELL 251 Dictyostelium discoideum AX4
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