1VA6


Conserved Protein Domain Family
glu_cys_ligase

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TIGR01434: glu_cys_ligase 
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glutamate--cysteine ligase
Alternate name: gamma-glutamylcysteine synthetase. This model represents glutamate--cysteine ligase, and enzyme in the biosynthesis of glutathione (GSH). GSH is one of several low molecular weight cysteine derivatives that can serve to protect against oxidative damage and participate in a biosynthetic or detoxification reactions. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs]
Statistics
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PSSM-Id: 213621
Aligned: 4 rows
Threshold Bit Score: 865.332
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1VA6_A         6 SQALAWLE--KHPQALKGIQRGLERETLRVNADGTLATTGHPEALGSALTHKWITTDFAEALLEFITPVDGDIEHMLTFM 83  Escherichia coli
O68838         6 SQALAWLE--KHPQALKGIQRGLERETLRVNADGTLATTGHPEALGSALTHKWITTDFAEALLEFITPVDGDIQHMLTFM 83  Salmonella ente...
WP_003109990   6 SRRLALLGaaANLPLLTECLHGIERECLRVDSDGKLALTPHPRALGSTLTHPQITTDYSEALLEFITPTETDVADTLGDL 85  Pseudomonas
P57485         6 SKKIAWLK--KNPKMLKGIFRGIERETLRIQKNGHFSKTIHPYLIGSSLTHKWITTDFSENLLEFITPTSDNIDYLLSFL 83  Buchnera aphidi...
1VA6_A        84 RDLHRYTARNMGDERMWPLSMPSYIAEGQDIELAQYGTSNTGRFKTLYREGLKNRYGALMQTISGVHYNFSLPMAFWQAK 163 Escherichia coli
O68838        84 RDLHRYTARKLGDERMWPLSMPCYIAEGQDIELAQYGTSNTGRFKTLYREGLKNRYGALMQTISGVHYNFSLPMAFWQAK 163 Salmonella ente...
WP_003109990  86 ERIHRFASSKLDGEYLWSPSMPCELPDEESIPIARYGSSMIGRLKYVYRKGLALRYGKTMQCIAGIHYNFSLPERLWPLL 165 Pseudomonas
P57485        84 TDLHSFTASKIKNERMWPFSIPYCFNDQTNIQIAQYGKSNIGKMKTTYRIGLKNRYGDLINTISGIHYNFSLPLFFWTNW 163 Buchnera aphidi...
1VA6_A       164 SGDISGA-DAKEKISAGYFRVIRNYYRFGWVIPYLFGASPAISSSFLQGKPTSLPFEKTESGMYYLPYATSLRLSDLGYT 242 Escherichia coli
O68838       164 CGVTEGE-AAKEKISAGYFRLIRNYYRFGWVIPYLFGASPAICSSFLQGKPTTLPFEKTDCGMYYLPYATSLRLSDLGYT 242 Salmonella ente...
WP_003109990 166 RQAEGSElSERDYQSAAYIALIRNFRRYSWLLMYLFGASPALDAGFLRGRPS--QLERLDEHTLYLPYATSLRMSDLGYQ 243 Pseudomonas
P57485       164 ENNQNKK-NNTDLISSGYLNLIRNYYRFGWIVPYLFGSSPAISSFFLKNTKKKYKFKKNKEDIFYLPWSTSLRLSDIGYS 242 Buchnera aphidi...
1VA6_A       243 NKSQSNLGITFNDLYEYVAGLKQAIKTPSEEYAKIGIEKD-GKRLQINSNVLQIENELYAPIRPKRVTRSGESPSDALLR 321 Escherichia coli
O68838       243 NKSQSNLGITFNDLHEYVAGLKRAIKTPSEEYARIGVEKD-GKRLQINSNVLQIENELYAPIRPKRVTRSGESPSDALLR 321 Salmonella ente...
WP_003109990 244 NNAQAGLTPCYNDLQSYIDSLRQAVSTPYPPYEKVGTKQD-GEWVQLNTNILQIENEYYSSIRPKRVTYTGERPVQALAA 322 Pseudomonas
P57485       243 NTNILDLNIMFNDFNEYIESFQNALKTPSKKFINIGLKDEhGNFKQLNTNILQIENELYTQIRPKRKTKDGESLLEALKN 322 Buchnera aphidi...
1VA6_A       322 GGIEYIEVRSLDINPFSPIGVDEQQVRFLDLFMVWCALADAPEMSSSELACTRVNWNRVILEGRKPGLTLGIGCETAQFP 401 Escherichia coli
O68838       322 GGIEYIEVRSLDINPFSPIGVDEQQVRFLDLFMVWCVLADAPEMSSDELLCTRTNWNRVILEGRKPGLTLGIGCETAQFP 401 Salmonella ente...
WP_003109990 323 RGVQYVEVRCLDINPFLPLGIDLDEARFLDAFLLFCAFSDSP-LLNGECSDATDNFLAVVKEGRRPGLQLQR--RGQPVE 399 Pseudomonas
P57485       323 RGIEYVEIRSLDVNPFSPIGINKNQILLLDLFLIWCALIDSPKIDKTDFLLTTKNWERIIYEGRKPNQKIYINNNNETKT 402 Buchnera aphidi...
1VA6_A       402 LPQVGKDLFRDLKRVAQTLDSINGGEAYQKVCDELVACFDNPDLTFSARILRSMIDTG--IGGTGKAFAEAYRNLLREEP 479 Escherichia coli
O68838       402 LPKVGKDLFRDLKRVAQTLDSIHGGEEYQKVCDELVACFDNPELTFSARILRSMIDEG--IGGTGKAFGEAYRNLLREEP 479 Salmonella ente...
WP_003109990 400 LQVWANELLERIADTAALLDRARGGEAHAAALAAQRAKVADAELTPSAQVLKVMRERGesFEAFSLRQSREHAEYFRQHP 479 Pseudomonas
P57485       403 LIEIGQIIFKDLNEIALILDSNSNDLLYQKACKETQLFLKNPELTYSAQCLNFLMTTG--IKKTGLYLANKYHEKFINKN 480 Buchnera aphidi...
1VA6_A       480 LEILREEDFVAEREASERRQQEMEAADTEPFAVWLEKH 517 Escherichia coli
O68838       480 LEILQEEEFIAERDASVRRQQEIEAADTEPFAAWLAKH 517 Salmonella enterica subsp. enterica serovar Typhimurium s...
WP_003109990 480 LAAEEQARFEKMASDSLAEQTELERDQDGDFDTFVAAY 517 Pseudomonas
P57485       481 YFNLNQSVLEQEVIRSHQKKIEIEREDILSFEEYIRNK 518 Buchnera aphidicola str. APS (Acyrthosiphon pisum)
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