Conserved Protein Domain Family
HSNSD

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pfam12062: HSNSD 
heparan sulfate-N-deacetylase
This family of proteins is are heparan sulfate N-deacetylase enzymes. This protein is found in eukaryotes. This proteinenzyme is often found associated with pfam00685.
Statistics
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PSSM-Id: 463450
Aligned: 22 rows
Threshold Bit Score: 716.008
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P52850         83 TEPVVLVFVESAYSQLGQEIVAILESSRFRYSTELApgRGDMPTLTDHTHGRYVLVIYENLLKYVNLDAWSRELLDRYCV 162  house mouse
EJD75808       76 TDEKVLVFVETLYSKLGKQIANILDALKIPLKVETL--TKNLPLLTTAKRGRFSIIIIENYYKYLNLLSWNRQLLDKYCR 153 
EGT38087       76 TDSKILVILDSLFSRNGKSIIQMLNSQKFAFKAEAV--SKNLPVLTNSRKGRYSLIIIENYYKYLNMAKWNRQLLDKYCK 153 
Q60V90         76 TDPKILVILDSLFSRHGKSIIQILNSQKFAFKAEAI--SKNLPVLTSAKRGKYSLIIVENYYKYLNMARWNRQLLDKYCK 153  Caenorhabditi...
Q966W3         74 TDARILVILDSLFSRHGKTIIQILNSQKLQFKAEAV--SKNLPVLTTSRRGRYSLIIIENYYKYLNMAQWNRQLLDKYCK 151  Caenorhabditi...
EFA03870      101 SYPKVLVFVETIYSKLGRDIAELLVHTRIKYKVEVA--GKSLPVLTNLDKGRYGVIVFENFNKYLQMDKWNRELLDKYCR 178 
NP_001163354  240 IDPKVLVFVETTYSGLGRDIAELLVYNRIKYKIEVA--GKSLPVLTNLDKGRYGVIVFENLDKYLNMDKWNRELLDKYCR 317 
XP_001603996   93 IDPKVLVFVETLYSRLGREIAELLVYNRIKYKVEVA--GKSLPVLTNLDKGRYGVLIFENLNKYLQMDKWNRELLDKYCR 170 
KAE9435686     95 iDAKVLVFVETTYSRLGRDIAELLVYNRIKYKVEVA--SKSLPVLTNLDKGKYGVIVFENLQKYLHMDKWNRELLDKYCR 172  Apolygus lucorum
XP_015782116  107 LDSKVLLFVESRYSHLGKMLIETLEATRIKFKFETL--VKSLPVLTNSDKGKFAVIIFENIEKYLHMDKWNREILDKYCR 184  two-spotted s...
P52850        163 EYGVGIIGF-FRAREHSLLSAQLKGFPLFLHSNLGLRDYQVNPSAPLLHLTRPSRLEPGPLPG--DDWTIFQSNHSTYEP 239  house mouse
EJD75808      154 EYGVGIISF-IGNRPNSYINAKVKGSRLTIHTQQRATNLRFNELSRVNFIGKPGAVLQAPEPDk-DDWILFDV-TNGYEG 230 
EGT38087      154 EYKVPVISFiSSKPEDHLKRIKIKGSSLWMWQNQRIYNLTVSP-SPIHKISRIGAYRNPNVPSspPDWVLFEIPSKNFEP 232 
Q60V90        154 EYRVPLFSFiASKPNDQLKRIRIKGSSLWMWQNQRINRLTVSP-SPIHKISKIGAYRNLTTQE--SDWILFEI-SENFES 229  Caenorhabditi...
Q966W3        152 EYRVPMFSFmSSKPNDQLKRIKIKGSSLWMWQNQRIQRLAVTP-SIIHRISKIGNYRQFSSSDp-ADWILFET-SEKFES 228  Caenorhabditi...
EFA03870      179 EYYVGMIGF-ITPEEETFVGSQLKGFPLFIHTNLKLKDAALNAASQILRLTRAGETAWGDLPG--NDWTVFQANHSTYEP 255 
NP_001163354  318 EYSVGIVGF-VSPSEETLVGAQLRDFPLFVNTNLRLRDASLNPLSSVLRLTRAGETAWGALPG--DDWAVFQHNHSTYEP 394 
XP_001603996  171 EYSVGIVGF-TPPGEESLVGAQLKGFPLFVHTNLRLKDAQLNAASPILRLTRAGETAWGPLPG--YDWTIFQANHSTYEP 247 
KAE9435686    173 EYSVGIIGF-LLGTEERLVGAQLRGLPLFIHTNLKLKDAALNGGSPVLRLTRAGETVWGPLPG--EDWTVFTANHSTYEP 249  Apolygus lucorum
XP_015782116  185 EYKAGIVGF-IPNKEGTIPNQEITGFPITIDYNMLIRDFKVDEESTILRLTKPGYLNPGPMLH--HKVNVFHSNHSSYRP 261  two-spotted s...
P52850        240 VLIA----------SHRPAElSmPGPVLRRAR--------------LPTVVQDLGLHDGIQRVLFGHGLSFWLHKLVFVD 295  house mouse
EJD75808      231 IVLT----------DDIFGEe-------------------------RASVILDDGSEDGIERILFGHNFTHWINKLAFLD 275 
EGT38087      233 VLTG----------TVRNGYe-------------------------RAVVIRDKGAEDGVERVIFGRNLTDFQVKMCFLD 277 
Q60V90        230 ILTG----------TVKNGYe-------------------------RAVVLRDLGREDGVEKVIFGRNLTDFQIKITFLD 274  Caenorhabditi...
Q966W3        229 VLSG----------TVKSGYe-------------------------RAVVVRDKGLEDGVERIIFGRNLTDFQVKITFLD 273  Caenorhabditi...
EFA03870      256 LEWA----------HRND-DyQ--PTESNVRTp-------------LPTVIQDHGLFDNIQRVIFGSGLKFWLHRLLFLD 309 
NP_001163354  395 VEWA----------QRNTQEyP-ADSVGQVQLp-------------LTTVLQDRGQLDGIQRVLFGSSLRFWLHRLVFLD 450 
XP_001603996  248 LAWA----------HRDSLDyA------TNKSp-------------LATVMQDHGRYDGIQRVFFGGGLKFWLHKLLLLD 298 
KAE9435686    250 LAWA----------NNNSHDwSdPQDHEDT-Lp-------------LSTVIQDHGGFDNIQRVFFGSGLRFWLHRLLFLD 305  Apolygus lucorum
XP_015782116  262 VTKAylfnpetyniKNRTHRySvSSEEESTSVenekfeifstyeetVSTVLQDKGLFDGIQRVIFSSGFDHWINRLLFID 341  two-spotted s...
P52850        296 AVAYLTGKRLCLDLDRYILVDIDDIFVGKEGTRMKVADVEALLTTQNKLRTLVPNFTFNLGFSGKFYHTGTEEEDAGDDM 375  house mouse
EJD75808      276 SLRYMRESLMYDDLERYIQIDIDDIFVGTSGTRMTKADVDALLQSQYRLRRDITNFTYSLGFSGYYFRNGDSLEDEGDER 355 
EGT38087      278 AIWWAMGTKETFQSDRYVQVDIDDIFVGAQGTRIVEEDVRHLLESQKSFRKSVENFKFMLGFSGSYFRNGDDLEDRGDEF 357 
Q60V90        275 ALWWAMGDEKLFGLDRFVQVDIDDVFVGAQSTRIVEEDVRHLISAQNHFRNFIENFKFLLGFSGSYFRNGDDFEDRGDEI 354  Caenorhabditi...
Q966W3        274 ALWWAMGNQKSFTLDRFVQVDIDDVFVGAQGTRIVEEDVRKLISTQKEFRNYVQNFTFMLGFSGSYFRNGDDLEDRGDEF 353  Caenorhabditi...
EFA03870      310 SLSYLSHGQLSLSLDRRLLVDIDDIFVGEVGTRLRPEDVKALIATQTRIQAMIPGFKFNLGFSGKYIYHGNSEEDKGDDL 389 
NP_001163354  451 ALSYLSHGQLSLNLERMILVDIDDIFVGEKGTRLRPDDVRALIATQKNIAAMVPGFRFNLGFSGKYYHHGTREENLGDDF 530 
XP_001603996  299 SLSYLSHGQLSLSLNRMILVDVDDIFVGEKGTRLKKDDVLALLATQQRIQALVPGFKFNLGFSGKYFHHGTSEENLGDDM 378 
KAE9435686    306 ALSYLSHGQLSISLNRYILVDVDDIFVGERGTRLRREDVQALLDTQERIQSLVPGFKFNLGFSGKYFHHGNPEENLGDDM 385  Apolygus lucorum
XP_015782116  342 SLSYLSHGKLSRPLDRYILIDIDDIFVGEVGTRVKPNDVRAILEAQSRLQTIIPGFKFNLGFSGKYYHRGNQEEDEGDDM 421  two-spotted s...
P52850        376 LLKHRREFWWFPHMWSHMQPHLFHNRSVLADQMRLNKQFALEHGIPTDLGYAVAphhSGVYPIHSQLYEAWKSVWGIQVT 455  house mouse
EJD75808      356 LIEVGKHFFWFPHMWKHNHAH-EHNQTYLEAVMTQNKLFAQGMDLHVNSGYAVSpqhAGVYPVHEALYNSWQLIWNITVT 434 
EGT38087      358 LVESAKEFVWFPHMWRHNHAH-EHNFTYLEAIMVQNRIFAQNMHLPVDYPYAIApqhDGVFPVHEEMFEAWKKVWNVSVT 436 
Q60V90        355 LIENAEKFVWFPHMWRHNHAH-EHNFTYLESIMVQNRLFAQNMHLPIDYPYAIApqhDGVFPVHEQMYEAWKKIWNVTVT 433  Caenorhabditi...
Q966W3        354 LVENAEKFVWFPHMWRHNHAH-EHNFTYLEAIMAQNKLFAQNMHLPVDYPYAIApqhDGVFPVHEQLFRAWRKVWNVSVT 432  Caenorhabditi...
EFA03870      390 ILENVDKFMWFSHMWNHQQPHLYDNLTVLMEDMVLNKNFAKEKGIPVDSGYSVAphhSGVYPVHELLYTAWKKVWNIRVT 469 
NP_001163354  531 LLQNVQEFNWFSHMWKHQQPHLYDNLTLLMAEMHLNYAFAVDHNIPTDSGYSISphhSGVYPAHELLYMAWKKVWNVKVT 610 
XP_001603996  379 ILENVDRFTWFSHMWNHQQPHLYENVTHLQLDMALNKQFAKEYGIPTGSGYSVSphhSGVYPVHEGLYEAWKKVWNIKVT 458 
KAE9435686    386 LLRNVNKFNWFSHMWNHQQPHLYENQTQLEFDMLLNKNFGKEHGIPTDSGYSVAphhSGVYPVHEALYAAWKKIWNIKVT 465  Apolygus lucorum
XP_015782116  422 LIANAHEFWWFCHMWGHSQPHLTENITALEIRMRMNKDFAHSNNIPIDSGYSVAphhSGVYPVHEPLYEAWKLVWNVRAT 501  two-spotted s...
P52850        456 STEEYPHLRPARYRRGFIHNGIMVLPRQTCGLFTHTIFYNEYPGGSRELDRSIRGGELF 514  house mouse
EJD75808      435 STEEYPHFRPASARRGFIHRNISVLPRQTCGLYTHTQFFHSYPDGFTKLLSNIEGGDLF 493 
EGT38087      437 ATEEYPHFKPPTARKGFIHNGIHVLPRQTCGLYTHTQLFDEYPEGFEKVIKSIQGGDLF 495 
Q60V90        434 ATEEYPHLKPATGRKGFIHSGIHVLPRQTCGLYTHTQFFDEYPEGFQKVIKSIQGGDLF 492  Caenorhabditis briggsae
Q966W3        433 ATEEYPHFKPATARKGFIHAGIHVLPRQTCGLYTHTQLFDEYPEGFDKVQKSIEGGDLF 491  Caenorhabditis elegans
EFA03870      470 STEEYPHLRPARLRRGFIHRNIMVLPRQTCGLFTHTMLIEKYPGGREKLDESIQGGELF 528 
NP_001163354  611 STEEYPHLRPARLRRGFIHRNIMVLPRQTCGLFTHTMYIDRYPGGRDKLDESIQGGELF 669 
XP_001603996  459 STEEYPHLRPARLRRGFVHRGIMVLPRQTCGLFTHTIFIERYPGGRDKLDESIQGGELF 517 
KAE9435686    466 STEEYPHLRPARLRRGFIHRNIMVLPRQTCGLFTHTIMIDRYPGGREKLDESIQGGELF 524  Apolygus lucorum
XP_015782116  502 STEEYPHLRPAQLRRGFIHRGIMVLPRQTCGLYTHTIFIDKYPGGRSKLDASIFGGELF 560  two-spotted spider mite
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