Conserved Protein Domain Family
Dpy19L2
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cd20179: Dpy19L2 
C-mannosyltransferase Dpy-19-like protein 2 (Dpy19L2)
Dpy19 proteins are C-mannosyltransferases that mediate C-mannosylation of tryptophan residues on target proteins. C-mannosylation is the attachment of alpha-mannose to the indole C2 carbon of the first tryptophan residue in the consensus amino acid sequence Trp-Xaa-Xaa-Trp/Cys through a C-C bond. This reaction takes place in the endoplasmic reticulum (ER) lumen. Dpy19 is a transmembrane domain family whose name is derived from the Caenorhabditis elegans Dumpy mutant. Dpy19L2 (also called protein Dpy-19 homolog 2) deletion is a major cause of globozoospermia.
Links
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Statistics
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PSSM-Id: 439132
Aligned: 3 rows
Threshold Bit Score: 1081.22
Created: 6-Feb-2019
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Feature 1: putative glycosylation site [posttranslational modification site], 1 residue position
Conserved feature residue pattern:NClick to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
P0CW70    118 RFSHRTLFGLAIFVGILHWLHLITLFENDHHFSHLSSLEREMTFRTEMGLYYSYFKTIIEAPSFLEGLWMIMNDRLTEYP 197 house mouse
Q6NUT2    103 RFSSRTTLGIAVFVAILHWLHLVTLFENDRHFSHLSSLEREMTFRTEMGLYYSYFKTIIEAPSFLEGLWMIMNDRLTEYP 182 human
NP_776173 103 RFSSRTTLGIAVFVAILHWLHLVTLFENDRHFSHLSSLEREMTFRTEMGLYYSYFKTIIEAPSFLEGLWMIMNDRLTEYP 182 human

Feature 1                                                                                     
P0CW70    198 LVINTVKRFHLYPEVVIAYWYRTIIgIMNLFGIETKTCWNVTRmEPLNEVQSCEGLGDPACFYIGVIFILNGLMMGLFFI 277 house mouse
Q6NUT2    183 LIINAIKRFHLYPEVIIASWYCTFMgIMNLFGLETKTCWNVTRiEPLNEVQSCEGLGDPACFYVGVIFILNGLMMGLFFM 262 human
NP_776173 183 LIINAIKRFHLYPEVIIASWYCTFMgIMNLFGLETKTCWNVTRiEPLNEVQSCEGLGDPACFYVGVIFILNGLMMGLFFM 262 human

Feature 1                                                                                     
P0CW70    278 YStYLSGSQLGGLITVACYFFNHGEATRVMWTPPLRESFSYPFLVLQMYILTIILRTStvhkKHYMALCFSNVAFMLPWQ 357 house mouse
Q6NUT2    263 YGaYLSGTQLGGLITVLCFFFNHGEATRVMWTPPLRESFSYPFLVLQMCILTLILRTSsndrRPFIALCLSNVAFMLPWQ 342 human
NP_776173 263 YGaYLSGTQLGGLITVLCFFFNHGEATRVMWTPPLRESFSYPFLVLQMCILTLILRTSsndrRPFIALCLSNVAFMLPWQ 342 human

Feature 1                                                                                     
P0CW70    358 FAQFILFTQIASLFPMYVVGYIEPSKFQKIIYVNMSSVALCFILMFGNSMYLSSYYSSCLLVTWAIMQKkskiqklggte 437 house mouse
Q6NUT2    343 FAQFILFTQIASLFPMYVVGYIEPSKFQKIIYMNMISVTLSFILMFGNSMYLSSYYSSSLLMTWAIILKrneiqklgvsk 422 human
NP_776173 343 FAQFILFTQIASLFPMYVVGYIEPSKFQKIIYMNMISVTLSFILMFGNSMYLSSYYSSSLLMTWAIILKrneiqklgvsk 422 human

Feature 1                                                                                     
P0CW70    438 lqFWLIQGCFWWCGTIILKFLTSKicGVSDHIRLSDLIAARILRYTDFDTLIYTCAPEFDfmEQATPLRYIKTLLLPLIL 517 house mouse
Q6NUT2    423 lnFWLIQGSAWWCGTIILKFLTSKilGVSDHIRLSDLIAARILRYTDFDTLIYTCAPEFDfmEKATPLRYTKTLLLPVVM 502 human
NP_776173 423 lnFWLIQGSAWWCGTIILKFLTSKilGVSDHIRLSDLIAARILRYTDFDTLIYTCAPEFDfmEKATPLRYTKTLLLPVVM 502 human

Feature 1                                                                                     
P0CW70    518 VITYLIFKKIVRDIMcvlytntyvrkqlldnaELIFHTLQLLAFTGLAILIMRLKLFLTPHMCIMASLICSQRLFGWLFC 597 house mouse
Q6NUT2    503 VITCFIFKKTVRDISyvlatniylrkqllehsELAFHTLQLLVFTALAILIMRLKMFLTPHMCVMASLICSRQLFGWLFR 582 human
NP_776173 503 VITCFIFKKTVRDISyvlatniylrkqllehsELAFHTLQLLVFTALAILIMRLKMFLTPHMCVMASLICSRQLFGWLFR 582 human

Feature 1                                                                                     
P0CW70    598 RihFENVVFGILTMMSIQGCANLHNQWSIMGEFTNLPQEELIHWIKHSTRpDAVFAGAMPTMASIKLSTLRPIVNHPHYE 677 house mouse
Q6NUT2    583 RvrFEKVIFGILTVMSIQGYANLRNQWSIIGEFNNLPQEELLQWIKYSTTsDAVFAGAMPTMASIKLSTLHPIVNHPHYE 662 human
NP_776173 583 RvrFEKVIFGILTVMSIQGYANLRNQWSIIGEFNNLPQEELLQWIKYSTTsDAVFAGAMPTMASIKLSTLHPIVNHPHYE 662 human

Feature 1                                                                                     
P0CW70    678 DADLRARTKIVYSVYSRKSAVEVRNNLLKLHVNYYVLEEAWCVVRTkPGCSMLEIWDVEDPsnaanpplcsillkdsrPY 757 house mouse
Q6NUT2    663 DADLRARTKIVYSTYSRKSAKEVRDKLLELHVNYYVLEEAWCVVRTkPGCSMLEIWDVEDPsnaanpplcsvlledarPY 742 human
NP_776173 663 DADLRARTKIVYSTYSRKSAKEVRDKLLELHVNYYVLEEAWCVVRTkPGCSMLEIWDVEDPsnaanpplcsvlledarPY 742 human

Feature 1           #     
P0CW70    758 FTTVFQNSMYRV 769 house mouse
Q6NUT2    743 FTTVFQNSVYRV 754 human
NP_776173 743 FTTVFQNSVYRV 754 human

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