5H1Q


Conserved Protein Domain Family
Innexin

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pfam00876: Innexin 
Innexin
This family includes the Drosophila proteins Ogre and shaking-B, and the C. elegans proteins Unc-7 and Unc-9. Members of this family are integral membrane proteins which are involved in the formation of gap junctions. This family has been named the Innexins.
Statistics
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PSSM-Id: 459975
Aligned: 177 rows
Threshold Bit Score: 157.355
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5H1Q_A        25 DLADRLNSRVTVVILAVSSALLLSSHFIGDPITCWTPAQFNAQWVNFVNQYCFVHGTYFV-----PLD---QQLA-FE-E 94 
CDS26017      31 DFIDQLNYQFTGGLILIFIIIISLRQYVGKPIQCWVPPEFTRAWEEYTENYCWVSNTYFL-----LPH---EDIPaEE-L 101
CDS39383      96 DFADRLNYQFSGVLMFLFIGVIGIRQYVGKPIQCWIPQEFTRGWEEYAENYCWVSNTYFS-----PLP---KRLPqSM-A 166
XP_003373184 421 DLVDRVNYYYTPIIIAFFSLTLSAKQYVGQPIQCWVPAQFTGAWEQYTENYCFVQNTYFL-----QLT---NQIPvDY-V 491
O44887        18 DSIDRLNYYWTPMLLVIFALTLSAKQYVGQPIQCWIPAQFTGAWEQYSENYCFVQNTYFI-----SPD---KYIPdSE-I 88  Caenorhabditis ...
KRY28588      20 DFTDRLNYYYTTLFLLFMSILVSAKQYVGSPIHCWVPAQFRGGWEEYAESYCFIQNTYFL-----PFG---KDVPsDI-I 90 
XP_003100252  20 DIVDRFSYQYTSTILGFSAIMMAASQYVGRPIQCWVPAQFTRTWEKYAETYCFIKGTYFLpgafaSEEemsVTSPdGGvT 99 
EGT29910      26 DTIDRINAWFTPFVLVAMTLAISCKQYFGQPIKCWTPREFSGSWDGYVHDFCFIENTYFV-----PNGtevTDQArG--- 97 
EFO82325      22 DAVDRLSYVTTATLLTFFSIMVSCKQYVGSAIQCWMPMEFKGGWEQYAEDYCFIQNTFFI-----PER---SEIPgDV-E 92 
CTP81065      22 DKVDFLNYYATSLLLALVALAISAKQYFGSPIQCWVPMEFRGGWEKYAEDYCFIQNSYYI-----PFT---EQIPeEL-H 92 
5H1Q_A        95 eERTKVS-IQYYQWVPYVFALQAFLFYIPRFIWKAMiAySG----YDLAAAV---KYVDRFw-SENRDKDD------KFK 159
CDS26017     102 eYEKIKF-IGYYQWMSIVLAGQAMMSWVPHLLWRVC-S-------RRLPLLL---KSAKEAs-IPDRELRL------KAV 162
CDS39383     167 -D-RDNArILYYQWAPILMAIQALLFYLPCLIWRLF-N-SHs--gFNVRRIM---QMANDSn-ILLPEHGL------KNV 230
XP_003373184 492 -ERDSRE-IGYYQWVPFILALQAFLFYLPCLIWRLT-N-WYs--gISVLGIT---NMAVDAg-NMDHETRK------KNV 555
O44887        89 -DREGAE-IGYYQWVPFILGLQAILFYLPSLFWRLM-N-FNs--gVALKKML---FGAKKAd-RVDEKARN------EAA 152 Caenorhabditis ...
KRY28588      91 -ERDYRK-IGYYQWVPVVLALQAALFYMPNLIWKMM-S-YNt--gIKLKSLL---QYASSIp-LTSSEERT------ETV 154
XP_003100252 100 -A-SA-Q-VGYYQWIPIILFVQAFLFYLPSIIWRTF-NeSCelkiKELAAVS---EASRKIksNMSDDQVKgrkfgrYFF 171
EGT29910      98 -D--R-H-INYYRWVPLVLLLQAAMFILPYSIWNMF-HkKTn---INLKGSLrffEDAMKK------QEPA------QAC 156
EFO82325      93 -DRQKAE-IGYYQWVPIVLAIQAFMFYLPSWIWSSL-Y-KQc--gLDFPSVI---SEAEALr-SSDSDTRK------KGI 156
CTP81065      93 -E-RNDQ-ISYYRWVPIVLALQALMFFAPNYFWNIL-Y-KEt--aIQPQGIV---KEAKKCs-TLHGHNRD------VEI 155
5H1Q_A       160 TRLAAfegrpsvYIWDGIRLarkkR------------------------------------------------------- 184
CDS26017     163 SCLVA-------TLEEQAES----Qsrfrrmksfv--------------------------------------------- 186
CDS39383     231 RFIAR-------YMEGCIYR----Lrdykrvistgagyaaaassfpyrgmqrfppetelpppgytkseletrrgggdkrs 299
XP_003373184 556 KTVAQ-------HIRQSLNL----Qrelstsgklf--------------------------------------------- 579
O44887       153 KSTGA-------HLYESLTL----Qsrfakyt------------------------------------------------ 173 Caenorhabditis ...
KRY28588     155 NRLCL-------IVEDCLNY----Qaskrsviski--------------------------------------------- 178
XP_003100252 172 KKLTF-------RNESPVFK----Etgki--------------------------------------------------- 189
EGT29910     157 ESFAR-------EVWGKLIE----Srkst--------------------------------------------------- 174
EFO82325     157 SKLVA-------FIEDILET----Rskneygrfy---------------------------------------------- 179
CTP81065     156 RNLAE-------YIGDTVSL----Fnsqdgfr------------------------------------------------ 176
5H1Q_A           --------------------------------------------------------------------------------    
CDS26017     187 ------------------------------------------------------------------------------nr 188
CDS39383     300 ngepnlgvslarrnkrttgslcgcgrgglgscwgsrssrrrsrklplnpitesspaaglaspaertdmtrrggkstpggy 379
XP_003373184 580 ------------------------------------------------------------------------------gf 581
O44887           --------------------------------------------------------------------------------     Caenorhabditis ...
KRY28588     179 ------------------------------------------------------------------------------lc 180
XP_003100252     --------------------------------------------------------------------------------    
EGT29910         --------------------------------------------------------------------------------    
EFO82325     180 -------------------------------------------------------------------------------c 180
CTP81065         --------------------------------------------------------------------------------    
5H1Q_A       185 -------SRNMALFYTLSTVWQAVNAWIQFYILTQLLDSSiYTLWGPS-ILGDLLQGNDWQTTGHFPRIVHCDFNRRRPA 256
CDS26017     189 clcgiapNARLTVLFLFVRALFIANCLGQIYLMKCFTGFN-STFFGLQ-LLQDLTKGEEWDTSGHFPRVTYCNIKVRVMG 266
CDS39383     380 nccgrrsGNFLVVLYFFVKGLYLINIVGQLILMEKFIGTN-TAFYGVR-VLIDLLQGSDWHTSGNFPRVTFCDFEAKKLG 457
XP_003373184 582 liygkhyGIYVTGLYLFIKFLYILNVVCQFLILNRFLGAQ-YTFWGFE-ILRDLAYGREWQESGHFPRVTMCDFDVRVLG 659
O44887       174 -saftygGSYLTYLYLFVKFLYLVQIVFQFIILNNFLGTS-YTFWGLG-ILSDILNGREWEESGHFPRVTMCDFEVRVLG 250 Caenorhabditis ...
KRY28588     181 fycrqtsSCYLTFCYLLMKLLYLINVCGQFLILNDFLSTK-YTFWGLQ-ILMDIAQGRDWNTSGHFPRVTFCDFEVRELG 258
XP_003100252 190 ----vasGKFLPSLYLLVKILYLANIVLQFWILTYFLDTK-SWLWGWQ-TFQDLVAGREWETTGIFPRVTMCDFSIMDLT 263
EGT29910     175 ---gkfyGCQATINYFLLKLGFIVNCILQMVLLKNFLDVD-DYFWGFFhLWNVEFKGTAEKDDSIFPRVVLCDFKVRNLG 250
EFO82325     181 yrfgkglGSMTSVLYICIKLMYLANVFIQFIILNKFLGNE-TFLWGFH-TFADLYAGREWQDSGVFPRVTLCDFSVRKLA 258
CTP81065     177 -mgftrsGRNATMLYLLTKLLYVLNIIGQIYMLNHFFGGD-YLQWGFQ-TITDVVSGREWMESTIFPRVIMCDFQVRRLG 253
5H1Q_A       257 SVQ--LDTVLCVLTLNIYYEKLFIFLWFWLVFVAVVSTVNCFKWIYYLCNKTKAQKTIK-----NYLSTA-PIKst---- 324
CDS26017     267 QPKpaSYSLQCVLPINNFVEKIYIFLWFWFVILCSLTIMNTLQWTINTMLPVRRVYYIK-----QYLKAL-RLIsste-- 338
CDS39383     458 KNQ--LYTIQCVLPLNMFLEKIFIFLWFWHCALGIITLISFINWFLRMGFARYRLKFIR-----RYLKIM-CVMkdtd-- 527
XP_003373184 660 NLH--RWTVQCVLMINMFNEKIYLFLWWWFFIISIFTFLNFFYWIFVSFNENMQVNFIS-----RYLRVS-DKIsdtlp- 730
O44887       251 NKH--RHTVQCVLMINMFNEKVYVFLWFWLVIVGVATFLNLVNWTRKLMFRSARKAHIK-----SYLQIE-DNFsddnsr 322 Caenorhabditis ...
KRY28588     259 NSH--RHTVQCVLMINMFNEKIYLFFWFWFLFLGIITGVNLMYWVSSFVSRTYKEDLVR-----HKLRLTiDFKdrlf-- 329
XP_003100252 264 TIH--DHSIQCVIVINMLAEKVYVFFWFWLLFVGILTGCSLLYWTVMYMLQSVGRNFIY-----SYLQNT-PSFeaeqek 335
EGT29910     251 QQH--QHTVSCIMILNMIIEKLYICFYFWLIFVFILTTVGMLNFGFQMLF--RRHSLIP-----TNLNNK-PSMnp---- 316
EFO82325     259 NVH--RYTVQCVLMINMFNEKIYLFIWFWFVFVLITTLVNTICTIWRLSIDSSRHNYIR-----SLLsggqhnm----kd 327
CTP81065     254 NIQ--RHTVQCVIMMNMINEKFYLFLLFWFIFIGICTVINFLYYLFLLCMSRARAQLVLwninkREWKLS-GFHnd---- 326
5H1Q_A       325 ---iSDDQFFSALGEDGLFIMDQMALNLGDIPASYLTISMRNI 364
CDS26017     339 -erdCTRFVNQNLGADGIFILHIVSKIASDLIALDVTATLWKN 380
CDS39383     528 -rsaSKKFVENFLRPDGIFLIRLISMNVGDMMAGDLACELWHI 569
XP_003373184 731 eqrrVGKFVRRELRPDGVFLLRIIASNAGDIIATELIKSLWTV 773
O44887       323 ngqiLDKFVDYKLKSDGVFITHLIDNNGGSVFSHDVIVDMWDR 365 Caenorhabditis elegans
KRY28588     330 errlTQQFIRDALHPDGLLIMRFIGTHAGELISSEMMGKMFRD 372
XP_003100252 336 gsqvPAHFVDNCLTADGVFISRLVQQNSGDLFTSIMLEEMFNL 378
EGT29910     317 --trSHRFIRKYLNFDGILLLTFIDSQFGAYRANQVIDGLIER 357
EFO82325     328 erfpIGKFTNHGLKQDGVLLMRFIDDHAGAMVTKEICSSLFQN 370
CTP81065     327 ---dMKRFVNDFLRPDGVLLLKFISEHVDARISRDLVNELIRI 366
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