3K8P


Conserved Protein Domain Family
Sec39

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pfam08314: Sec39 
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Secretory pathway protein Sec39
Mnaimneh et al identified Sec39p as a protein involved in ER-Golgi transport in a large scale promoter shut down analysis of essential yeast genes. Kraynack et al. (2005) showed that Sec39p (Dsl3p) is required for Golgi-ER retrograde transport and is part of a very stable protein complex that also includes Dsl1p (in mammals ZW10), Tip20p (Rint-1) and the ER localized Q-SNARE proteins Ufe1p (syntaxin-18), Sec20p and Use1p. This was confirmed in a genome-wide analysis of protein complexes by Gavin et al (2006).
Statistics
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PSSM-Id: 429913
Aligned: 66 rows
Threshold Bit Score: 338.507
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3K8P_D         7 YLLACIFASRADTRNIKK-LSTRLGSQSK-------------YLEILCVLW-PELDDP----KNLLFLrel--------e 59   baker's yeast
XP_002548758 106 VYTIQLVSSSTDIDKLQAfLRLLNAKVLSsdtneftfttknnLLNAILVHTyPLNLELeeltKLANLL------------ 173 
XP_004181677   7 YLLTCIFASRGDSLNLKIiLKNEKVNGVNfv----------eKLNIVCVLW-PELDDP----SNLKFLftddeemtddsd 71  
XP_003672426   7 YLLACVFASKADSTNLSQ-ILRHVHYSLD-------------FIKAACILW-PELDDP----MNLISLfptielgnddnd 67  
CCC72177       7 YLLACLFASRADSENLIR-VLHHVEYSMK-------------FVKIVCILW-PELSDP----LSLRFLfn---------- 57  
XP_002495557   7 VILAAIFAARADSTNCET-LWTFFHSSDE-------------LFDIICSLW-PELDDP----TKLQFLfd---------- 57  
EDO16615       6 YLLCTIFAARADITNSSL-LYDQANGNFTq-----------eCFDALCILW-PELMDP----NGLSFVfq---------- 58  
XP_003684281   7 YLLATIFASTADVEKLTI-LKNSFTNSSE-------------LLDIICVLW-PELDDPillrNFLTNLel---------- 61  
EMR10476      11 LYIAVQYASAPSLQTLSE-LILKFPYIFSkr----------vILSI-LNFV-PECIDPdeylSLIFDEky---------- 67  
EPB88423     175 IAQAIEYARSENNVALDAiFMHHGSDVLEhr-------------lFILSQI-PETADPsl-----fDL------------ 223 
3K8P_D        60 eeVQ-SPEGEEttdedvivelLESDSSLIPL---IESDTTTRSNRYHELQEfiskklnnktL--------------ENFE 121  baker's yeast
XP_002548758 174 --ID-PSNITKtd------etDSFDVEEFAFglpTQIENESSLLATAQDLMvdtnvqssyiGglkfg-----stpdDLLL 239 
XP_004181677  72 liRSyDGDDIYrnpadlvvniLKNNEELISI---IESDHNCLNERYDHMVDyintklsviqtl--kgsldvlntelSLKY 146 
XP_003672426  68 nnAS-ANDDGSlsdenlvvklLENNPDLIPL---VEVGNTIVNTRYLSTKYfiesklnglySsniipletslssleDLQS 143 
CCC72177      58 -hQK-DAQVKPmtdeelvvslLEKDSMLIPM---VEINNETVSNRRQQLEQfinskwdsltSindid-----tsssSSSI 127 
XP_002495557  58 psEK-SSSGHStnpqdllvelLETDEQLISM---VEMDSDTITQRRQAISRyaaeymkqvtPydri-------kfvTPMG 126 
EDO16615      59 qgPS-DDQVQLsdpndlmmnlLEVDNKLIPI---IELEHDIVHERSEKVKDfvskrilqleQdsli-------tfdNILS 127 
XP_003684281  62 -nDL-NADENPidednilvslLETGEDLVPI---IEMDVETVSERVSTVKEyinrrlvevtLdeit-------sfdDTVS 129 
EMR10476      68 --------------------eGEDDMDSSQIsktQNINNAALSQKLKKLHI----------Yqdetkt--nncisdEELY 115 
EPB88423     224 --PH-VTHDHEdswleepwrkEKDAVEQDWVqtlIRVQVPEETEYLERLkggiett--------------pyptsaSVIA 286 
3K8P_D       122 EWLRERILICNexiPETPLLYSVLWETAksk-------vlSTKFIGW---VEGVLKPLDHLNKRLHLIf----KINEWEK 187  baker's yeast
XP_002548758 240 SFIQAKTIQLSkyfDNVNDIMPLYERVS------------SDAFQSW---FAGVISP-----YKYYYDh--------YGQ 291 
XP_004181677 147 TWLKNRIILVNnfyPMDTIFNRTLWSLKvfrdkp-indqsHSIFFNW---INGTIYPLYYINQRLNKTl----KIQEFEN 218 
XP_003672426 144 LWLQIRILVCNeviPEMTSFYEPLWTHSnf--------hiNKEGKDW---IECIIEPLNYINSRLGSKl----KIKDFSK 208 
CCC72177     128 SWLSKRILLCNdsyPGDVFFYEPLWnllikd----gvvseKDRLFQW---IKGIIIPLHSISIRTHAMt----KIIDFEK 196 
XP_002495557 127 DRLRKRLITSNelsDQLPMQYHPVWkvv---------sikDEELPKW---IEGIVEPLDHLNKRLNSSi----KIKEFEN 190 
EDO16615     128 NWLRRRILVCDefnPNNVLFNEPLWeth---------skdDIKFAQW---ISGIIKPLSYLNLRSGSKt---lKIKDFEN 192 
XP_003684281 130 SWLRKRILLCDelnPFNVLFNKKLWkei---------kpiDPEFMGW---VNGILEPLDFINNSSDIRvq--fRIIDFEA 195 
EMR10476     116 AWFISRALQIE---EETGLISFSRKLVLtsk------ypiPPKVQEWgrgIVSTLESVINRQYNNPLLefnvpTLREFET 186 
EPB88423     287 SWYLDRAHAAD----SIGLSSSALEICRyarvmgvtgideQVSEYEW---LCKYVY-LAKAKLDQEGAy---vDLKTFQR 355 
3K8P_D       188 XPDSELFKIIFDGVe-DXqGYIGIADVIEDELAPTLSYG-----------------------KKWETFI----------- 232  baker's yeast
XP_002548758 292 VYNGATLQEYLSAG-------ETLKNKFEMLITPLSAGKvsnieqwianviipiimyhnndfRPLNEWLfysdmgatvtk 364 
XP_004181677 219 LKTEDVINMILNSQ------ETLKKETIVNELFPYIRYN-----------------------NCFDLYL----------- 258 
XP_003672426 209 MDPIAVFPLILEGG------------DMKKELIPYLQYT-----------------------KSFTSFL----------- 242 
CCC72177     197 MNATVTFPLILDGK-------------IFHELIPYLDFT-----------------------NLSNEFI----------- 229 
XP_002495557 191 MDPLSVFDMILNTP------DENPDTVLQRELMPYMANG-----------------------DYYERFL----------- 230 
EDO16615     193 FKPVDIINLILGNIndDEyNLSIDASIIIQELIPYLKYS-----------------------KAYDIFL----------- 238 
XP_003684281 196 LTPNNVIELLTKNLleNEySFNNKNVQQIDCLISYLNYT-----------------------NSFTLFL----------- 241 
EMR10476     187 LNHKEVIDILLQHL-----ENEEILEEIKSSIIPYISYCqkssk--------------tniwDSLWSWLlnfsfkq---- 243 
EPB88423     356 ISSYEILEGLLSST-----NAANIVDDMLRLALPWISMAnkrkhvnd--------hnsakkeFLLYRWLldpavv----- 417 
3K8P_D       233 -------TEFFNKQQFSlksdtnyqlfIKLY-------YSleKGVKDNSEASRKLQSNVVDILF------HNSenlF-NL 291  baker's yeast
XP_002548758 365 gsnktspVTKYSVWSSCisslnrhfelEEFK----------------------VIIETYLAACYyfsfkeDTDvvsSvDI 422 
XP_004181677 259 -------ESFFNSDKIQinnlsdyqrfKSLFieineeiRSffGNLDELTSINSKFQTNSLDIIL------KNNkwlItQF 325 
XP_003672426 243 -------NNFCTVTQFPmdnqenyellDNLId---------iLPSVLPQDEIHTFKTSLLRIIF------ENSgnlL-KF 299 
CCC72177     230 -------ENYFTNENFLlatvqnydifRNIFf---------aFSNETSKSNFDKVCGNVANILF------ENSsnlL-NF 286 
XP_002495557 231 -------HSFLTTKDFPlntnynfevfYQLI-------LSlgLRGQETNKYLERFKRQCAYILF------KNGpnyL-NI 289 
EDO16615     239 -------DIVFNPSVFRfdtavnyynfRQLYs---------lLSNEIPIEFKEKLEELSLKIIY------DNSanmL-NV 295 
XP_003684281 242 -------EQKFNTNSFLfkkkqnylvfDAIFt---------kFNESNVMADKENFQKAALSIIF------ENSkelM-NI 298 
EMR10476     244 ---------------------knlnliKLIS-----------FNNVISSEKYSEFSKYAIASCYcl---qSTE---EeNI 285 
EPB88423     418 -dahldwCCVVFEHSKPtiavedriikDDLD-----------------------LSRLVLAIVY--------------SG 459 
3K8P_D       292 SSLTHKLDELWSILSgfp----------------------deITIEEqKTITALExKQFXEFFIKCSTKF----SF---- 341  baker's yeast
XP_002548758 423 MKSYEVIHDTLSLLRgssktlapgsqdidygnipmdcasfneFNTPS-NPLSALFhSECIPELKHAIETCqklfPInkl- 500 
XP_004181677 326 KGTK----EINELIIrid----------------------hnIEAK--KYGNCFKiKKILRIIENIFHNDit-yTI---- 372 
XP_003672426 300 TTLA----TLSNLVNvtad--------------------nsvMLTDY-DNLHYYDlQKYLLFMQNFSKSKd---SF---- 347 
CCC72177     287 KSLE----ELKNILNrip----------------------kdTPIAK-YDITVADvTEYIRYMEVMLSNY----SL---- 331 
XP_002495557 290 GTKY----RLNQVLLtig----------------------deTPVGD-LGITVETlLAYSSLTDKLFHGY----HM---- 334 
EDO16615     296 TSSS----ELEQLLTqfs----------------------pgTKVKS-TSLTANNlKWFAHYMNLCFQGY----SL---- 340 
XP_003684281 299 ISMD----ELKQLLDafd----------------------qnIETA--NGINSKIlLSYIHLISIFLQDY----SL---- 342 
EMR10476     286 HSMKIILQNLKQNLNietnsntsvlnd---ikisslnvftpeNIQDY-SELITPN-SDSLSLLEIMIKTVliinSTkeic 360 
EPB88423     460 NGSMEYLVRLFECLPifddinensndptdmaaimpkatspmaIFMEL-QSVGEYGlTQMMDTLQGHLGSAetlaRY---- 534 
3K8P_D       342 --KEIF-AI-TQEEE--SAQLAHFSSLCHEEfNKA------NEISSFLQAXYETVLDI-SK---DDKIFTRI-SXDEKLY 404  baker's yeast
XP_002548758 501 tlKKYLqFN-YDPSS--IDLEREILRITSNI------------NHSNWQQLMRSVDlfkssfvseenTNGQV-SSIIIER 564 
XP_004181677 373 --DEINdTI-ENNNK--EQQVSKFTEFLENLmKNGysfrieKLITNSE--------NI-KD---IKFVFNKFeTTEEIER 435 
XP_003672426 348 --KDLY-LI-NKGTE--SSQLAHFASICKEElSANan--kpSINNAKIKDIFDSI-VH-ED---NDMVLSHL-TIERKIS 413 
CCC72177     332 --KEVY-TI-SQEEE--SAQLAHFASSCKEElMAAlnnneeSTLSQKLNSLYT---LS-NA---SSSVFNRL-STKIQQS 397 
XP_002495557 335 --QDLY-AI-SKDDE--SVQESHFASLSRKClETVvs---eETTMKELKELLKH--GK-SS---NNVIFSRL-SEQKKLS 398 
EDO16615     341 --SDIN-AI-CQSSE--QEQLAHFASMVKGKiCNSqsqqtiDVISNLISE------SK-IK---EKQIFTNL-TIDKQIS 403 
XP_003684281 343 --KEVH-LI-SKENE--ASQLLHYTSMIKAKiMSKgfktssSTAVNEILSVITGS-AS-NS---EQIVFTHI-PPKRQIS 410 
EMR10476     361 kiTLSEaVCyRNKDK--KSQISLLHKMIPQN-PHFl----sKLNDSEWIKLRNNIKwlhd----vslIYKNI-PEIEYES 428 
EPB88423     535 --NAHVpLRwYLEDQsvEAQRQLCVRMSSQAaGGVesggakFDRDDDWRELLDDMIrlngD---GQGIFGKL-ENAEILE 608 
3K8P_D       405 SILEILLQXNEFAYIEAI----------IERFDYSNntqiyeLLVKFFWHFFNNASN-GLRKEPEXKKASQTLQIIQKHX 473  baker's yeast
XP_002548758 565 LLFANL-----FDVADELffnd--sllpISTNQFYS------LVEEKFWASLNHAVN-LNEKSGLLYNAHQCLNLFDKLV 630 
XP_004181677 436 LVIDILMNYREFDLVGDI----------LGSHSDEDsqi-ndIVIKYYWKTIKKFNNdGTKKNVEMLNIEKILTILKH-- 502 
XP_003672426 414 ILLETVLDLGEFDVLEEV-------------VTQYKekfitkLLLKFFWIYFNNSTN-GSKKSLGMTKCRKVLNLLSLEA 479 
CCC72177     398 ILLETVLDMGQFDILHEF-------------MSEYGsnletdLLEKYFWKFFNNATN-GSCKRAEMIKSQKTLNLLl--- 460 
XP_002495557 399 IIIEILLEFGNFSFLHEL-------------IITYQykvneeVLVKYFWHFFNMASS-GQRHKRDLANAEKLVNLLl--- 461 
EDO16615     404 IFVEILLELGEFDLLQNF-------------VTLNNskleenVLEKYFWNFFNNATN-GLKSRPEIKKAEKTLQLMd--- 466 
XP_003684281 411 VLIDLLLELGEFDLLQDL-------------MEEQNsqleeaGLEKYFWHFFNNASN-GLKSRPEMKKAQKTVKLLl--- 473 
EMR10476     429 FLLYNILRTTKFNLAENIyikrnkgnmpLKDVMVEK------ICIEIFLEFFDSSSN-GNITKGNMKNAYNLLQTIKQYY 501 
EPB88423     609 IFFYSLLRCGRFKLAKELi---------FGSKRIMDmtkaehLVIDAEREFFDNATS-GNMNSGSMKQAWDCLKIL---- 674 
3K8P_D       474 s------QRAGTNLTKLEVLLEISDKL-SHYSINLNKshnGArd--tAFKPSNILEYr--DCPLDIISNLLELNPRLYKD 542  baker's yeast
XP_002548758 631 lkk-dleESSRQQIVKFKHLFKAMHAL-KNFKIVIVS---SDadrnkPLTPYALINSfadNNVMNLITIVLEQNPKSYLA 705 
XP_004181677 503 -------RKEVNEYHYLRQLVNNCYEL-SKYSI----------------KPIDIIQYk--QEPIKIISKMLENNNGLYKE 556 
XP_003672426 480 htkgrqdLITKEELNSLQTLLDVSDDL-SKYSMNLGK---GH-----IFKPSNILDFe--TKETGLISILLESNNSIYKD 548 
CCC72177     461 -------KQDAKKYERLQSLLDVADEI-SRYSMNLGR---GI-----IFKPSNILDFq--EDPYQLISTLLELNSSLYKD 522 
XP_002495557 462 -------EENAPKYTHLRILLDVTKDI-CDYSINWGR---SL-----PFRPSHLLKFk--EDPFGLISLLLESNRRLYKD 523 
EDO16615     467 -------VQNSTVYKHLHTLLKVADTL-SRYSINLGK---GI-----PFKPCNIFEFk--YNPSKLISILLELNRDLYKD 528 
XP_003684281 474 -------EQNEPKFKHLEILLHIADLL-SYYSINLGK---GV-----IFKPSNIFDFk--NHPSQIISKLLELNDGLYKD 535 
EMR10476     502 -------NSEQ--LESFSYLVKVTNTL-YHYS---------H-----KFKPVQIRLH---NNPFEILEDFLSSNPGIYKS 554 
EPB88423     675 -------PPSTE-IKKEVDLIEATHTLiYEYKVQDHP---GI-----TLMPIQIRQS---QNRLELISKLINNRAGMYQR 735 
3K8P_D       543 LPTTKSLLFGIYDSlsiNREg------------qTGKVEVDLXVLHIDYALVNLDFGTAYELGKQVFeicqeag------ 604  baker's yeast
XP_002548758 706 FEKLYRILNDLLIFfged------------gdgeNNFYFKKLKTACIESALIDNNFNYAYTQSIELFkffedk------- 766 
XP_004181677 557 FEI---FNEKVYNNlqiEI---------------TNDERIEIINLQIINSLKNFDFNFAYQMIQDLFanyq--------- 609 
XP_003672426 549 ISVTFEIMKKLNVAmacQCPfinhnqlkpaqkkdVIVAYMRLLTLHIDYSLVNMDFNFAYKLTMELFdkfktyigqqset 628 
CCC72177     523 ILVTFTILKKLYTAlekSSLrs----------tnFDYEYDKLLIIHIDHALVNMDFPFAFNMTKELLeremks------- 585 
XP_002495557 524 VPATYSILQKLLVAfeiAKQgt----------tdSEENLVKVLVLHIDHALVNMDFQFAYENTRDLLkk----------- 582 
EDO16615     529 VANSMNLIDQLVEAmqiSREhl-----------dRESEYNKILVIHIDHALVNMDFTFAFQKSKELLrr----------- 586 
XP_003684281 536 KNTTSLMLKELFEGmnlDITgd-----------fFVQEQIRVSEFHIDNALANLDFYFAYHESKELLtk----------- 593 
EMR10476     555 IDEVMEICNDLLLStnkNYLy-------------QKEIQAKILCIIAETALSQNEFDFAYDICINHLfslfeavd----- 616 
EPB88423     736 HEQVLELVRKLGYGn-------------------DLLAKVKTLAMLASAALVEGDYLESYKLCQITTtaavnkdasn--- 793 
3K8P_D       605 ---qhxxkalGDEHWLTFYQXGKFVDPnw-------------vdNEIPTEIIVLQXSILGRLLEVCP-LEEVEIVTSQWS 667  baker's yeast
XP_002548758 767 -----pndrrIDELWLTFYQVGKYISPewfdepe----------ktidlevLTKQREILSLTIATLSlGENSKIVINQWQ 831 
XP_004181677 610 -------aesYQKYWETIYLFVKFTDPkwfdinnygdnsrnessDELPINIIITKLEIIEELSNICP-VEESEKVINYWS 681 
XP_003672426 629 sgiatderfnLCDYWLTIYQVGKFIDPnw-------------ldNEIPTEILMQQMKILSKLLYVCP-VEEVEPIISYWS 694 
CCC72177     586 -----enddlIRDHWLTIFQVGKFVDPnw-------------ldNEIPTEILMSQMEVLAELLNVCP-VEEIEIITSHWS 646 
XP_002495557 583 --------knIIDCWPTILQVGKFVDPnw-------------rdGETPTEIIFLQLEILGELLQICP-VDEVEAVASQWS 640 
EDO16615     587 --------dsVSTYWATVFQVCKFINPnw-------------idSEVPTEYLILQLELLGDLLSVCP-ADGLDIVVSQWS 644 
XP_003684281 594 --------seNKTPWATVFQVCKFSDPnw-------------ldNETPTEILVLQFELSSDLLQSCP-TEEMEIVISQWS 651 
EMR10476     617 ---iktrealSNIIWKSCLQISKNYETees------------------lenIKKKMFLLSKVINICP-KEYLVEVLNVWK 674 
EPB88423     794 -hnkkyndevDQSAWQICFNLGKvda----------------------fddISRRLDVLSMALTLSP-AENIGDVLTVWR 849 
3K8P_D       668 TL------ELELSARdLVKDKYALDGQ 688  baker's yeast
XP_002548758 832 SL------NDKIQRVsLENDIDKVKQQ 852 
XP_004181677 682 EL------ELELATRdIIYEAEYIEKD 702 
XP_003672426 695 GL------ELELSIRdLVNDKYSLEk- 714 
CCC72177     647 GL------ELELSARdLVKDKYSLAs- 666 
XP_002495557 641 AL------ELELLTRdLIKDPYSLEKS 661 
EDO16615     645 GA------ELELSTRnLIDDKYSIENM 665 
XP_003684281 652 SL------ELELLTRdIINDQYSIgns 672 
EMR10476     675 RF------EKEQLSI-RSKKLSEFNDn 694 
EPB88423     850 KLggnsfnQIELAQLsASNNNNDqnls 876 
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