4DA2,4DAV


Conserved Protein Domain Family
SfsA-like_archaeal
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cd22358: SfsA-like_archaeal 
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Sugar fermentation stimulation protein A and similar nucleases
Sugar fermentation stimulation protein A may bind to DNA in a non-specific manner and may act as a regulatory factor involved in the metabolism of sugars such as maltose. However, it contains a well-conserved PDDEXK nuclease active site and may have hydrolytic activity towards an unknown target. The putative catalytic domain belongs to a superfamily of PDDEXK nucleases including very short patch repair (Vsr) endonucleases, archaeal Holliday junction resolvases, MutH methyl-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and FokI.
Links
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Statistics
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PSSM-Id: 411762
Aligned: 44 rows
Threshold Bit Score: 208.606
Created: 29-Jun-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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putative activeDNA binding
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1: putative active site [active site], 5 residue positions
Conserved feature residue pattern:x D E K [HQ]Click to see conserved feature residue pattern help
Evidence:
  • Structure:4DA2: Pyrococcus furiosus SfsA binds divalent cations; contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
4DA2_A        10 LFPCIFLRRVNRFVGLVRIKERIERALITNTGRLNEFMIPGRIGYCTPKAg---GKTRYILLGFEd-hGKIAIIDTRLQG 85  Pyrococcus furi...
Q9YEX9         8 DEEAVFLRRVNRFVVEVKSSRGVVRCHLMDTGRIDHLASPGRRGVLIAWLnrlgGKTVCRAQAFKtagGVVAVVDSRVPN 87  Aeropyrum perni...
RUM29655       6 VIPAIFIKRLNRFVGEIFLEGRKQRALIRNTGKLGELLKPYNTVFVRKKSk---GKYLYEILIARt-eKGLVCIESHYAG 81  Aquifex sp.
PMP91465       5 LKECIVLERLNRFVAKVIVDNQETLVHVRNTGRLPELLVKGAKGLLEKKEg---GKYQWHLKAVNk-nGHWVYIDSLLAP 80  Hydrogenobaculu...
GBC85077       9 LRKAVFLERKSRFHGRVRDGRRVRTVHIPNSGRLRELLFPGNQVGYRPRRadpgRRTQGTLLLARtpsGGWASIDARLPP 88  bacterium HR11
RME11850       6 LIKANFIQRLNRFVGLISLEDKELTAYIRNTGRLRELLFSGNEVYVAEKTi---GRHPFEIILAKr-gDYLVCIDSHIAP 81  Aquificae bacte...
WP_096602139   6 LVPAKFVRRVNRFLCMVQLGNKETLAYIRNTGRLKELLIEGSPVYLKEKDt---GKYKYEVLLTEtnrGFLVCLDSQIAP 82  Hydrogenobacter...
WP_012991353   6 LREAIFLERINRFICRVLYRDGQHTAYLRNTGRLRELLKEGTKVYVREKEg---GKHPLELLLVDa-gSSLVCVDSTIPP 81  Thermocrinis albus
WP_025305241   6 LIPAKFLRRLNRFVGEVSIEGKRVFAHIRNTGRLTELLKPGNTVFLKEKNs---GKYPFEVLLVDm-gSSLVCIDSTITP 81  Thermocrinis ruber
WP_079654630   6 LKEAIFLQRENRFVGKVLLNREEVRAYIRNTGRLTELLRRGNKVYLKEKH----QGKYPYEILLVdymGTLVCIDSHIAP 81  Thermocrinis mi...

Feature 1                                #            #            # #                      #    
4DA2_A        86 KAFEKIIeke-llPELEgcRIIKREPRVg----eSRLDYLIEcskgEIFVETKSAVLREGEYamYPDCPSVRGQRHIKEL 160 Pyrococcus furi...
Q9YEX9        88 RLFAEAApmv-vgGDAS--IEAEREVFG------SRLDFLIStgrgLWAVEVKGVNLSLDGVglFPNAPSARAVKHLEVL 158 Aeropyrum perni...
RUM29655      82 KLFEEYVr----dNWKF--SILKREVKIg----nRRIDFLID----DKLVEVKSVNLVKNGVamFPDAPTKRGKEHIETL 147 Aquifex sp.
PMP91465      81 KLFLDFIkk---eGWFDi-KSLKLEPKYgn---hHKFDILINn---EIIVETKSVNLVKDGIamFPDAPSERGTKHIELL 150 Hydrogenobaculu...
GBC85077      89 RLLLEYLqrhrasLWGRl-RAWRLEPPIplgdhrGRLDLWVEtdggVWWVETKSVTLVRDGVgyFPDAVTVRGRHHVEAL 167 bacterium HR11
RME11850      82 KLYVEWVs-----SPAI--FEPRFGNKR------FDLLINGR----PIEVKSVNLVENNTAL--FPDAPTLRGKQHIEKL 142 Aquificae bacte...
WP_096602139  83 RLYAETL------TQQH--VIYEPRING------SRLDLLVG----RYIIEVKSVNLVKDHTalFPDAPTKRGTKHIHIL 144 Hydrogenobacter...
WP_012991353  82 FLYEEYTg-----VKGK--REPRFGNVR------FDLLVDKK----IIETKSVNLVRDKVAL--FPDAPTLRGRKHVEEL 142 Thermocrinis albus
WP_025305241  82 KLYAEFLn-----LPVR--FEPKFEKHR------FDLMYDSR----VVETKSVNLVEDGVAL--FPDAPTERGRRHIQKL 142 Thermocrinis ruber
WP_079654630  82 KIYAESL------MPKN--VVFEPKVNA------SRFDLLVD----DLLIEVKSVNLVVNGValFPDAPTKRGARHLREL 143 Thermocrinis mi...

Feature 1                                                                                 
4DA2_A       161 IKLArdg-krAMIVFIGALPNVSKFKPYkkgDPKIAELLKEALEaGVEIRALGLHMEl--sGEIIYRGELGVE 230 Pyrococcus furiosus DS...
Q9YEX9       159 ARLAreg-vkPLMAFVALRPDIRVFAPNyrvDRRFASLACTLLRrGLVGMVGIRVSIdlepGVVRIRPVATAP 230 Aeropyrum pernix K1
RUM29655     148 IRFSdk--ykPLLVFVVQREDFEEFKPNcetDPDFCKAFYKYINmGFEVMVLRCKVYlgeiKVIEKLNFYGKT 218 Aquifex sp.
PMP91465     151 KNIYatkeykPMIVFVIQRPDAKVFKPNeetDLSFSKALKEAKEiGIDILCLDCHTSe---NEIFIKGQIPKA 220 Hydrogenobaculum sp.
GBC85077     168 TAMHrag-ypVALVFVVQRSDARAAAVDgqtDPALYEAVRSARAaGVPVRAFACRVT----WRSIRIDREIPF 235 bacterium HR11
RME11850     143 IELSkeg-ynPLIVFVVQRGDAEVFSPNwrvDPEFSKALLRYFQlGLEIRAYRCSVSl---EEIKLKEEIPVE 211 Aquificae bacterium
WP_096602139 145 INAYpk--fvPKMVFVVQREDAKVFSPNaetDPVFAQMLKRFAHlGYEVKAYNCFVSl---EEIKLKEEIEVI 212 Hydrogenobacter hydrog...
WP_012991353 143 IKLGeeg-yePLIVFVVQREDALYFSPNwdtDPDFCRALVRYREkGFQLQAYACKVSm---KEIMIEKPLDII 211 Thermocrinis albus
WP_025305241 143 IELSeqg-fePQLIFVVQREDALVFSPNykvDKPFSEAVQEFYNrGLTVKAFLCNVSl---REISISREIEVI 211 Thermocrinis ruber
WP_079654630 144 AYLIds--rpACVVFIVQREDALAFAPNcsvDPEFCKAFEEFRRkGGMVKAYRCSVSi---EGISLKDEIIVL 211 Thermocrinis minervae

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