4X86


Conserved Protein Domain Family
Tugs

?
pfam17840: Tugs 
Tethering Ubl4a to BAGS domain
This is the C-terminal domain of Ubiquitin-like protein 4A an ortholog of yeast Get5. In budding yeast, GET proteins directly mediate the insertion of newly synthesized TA proteins into endoplasmic reticulum membranes. Similarly, mammalian BAG6, Ubl4a, and SGTA make up a trimeric complex that binds TA proteins post-translationally and then loads them onto the cytosolic ATPase TRC40, which in turn targets them to the endoplasmic reticulum. Structural studies show that this C-terminal TUGS domain of Ubl4a is essential for BAG6 tethering. Given that BAG6 mediates oligomeric complex formation of Ubl4a, TRC35, and TRC40 (mammalian counterparts of Get5, Get4, and Get3, respectively), the C-terminal TUGS domain might be crucial for supporting BAG6-mediated Ubl4a-TRC35 complex formation in humans as an alternative to the direct Get5-Get4 interaction in yeast.
Statistics
?
PSSM-Id: 465528
Aligned: 12 rows
Threshold Bit Score: 74.3605
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
4X86_A         7 WQLISKVLARHFSAADASRVLEQLQRDYERSLSRLTLDDIERLASRF 53 
XP_003421802 102 WQLIAKVLGRHFSSADANRVQEQLQREYERSLSRLTMDDIERLASRF 148
XP_006625650  87 WHSLSAVLAKHFTPTDAAKVQEQLIKDYERSLRQLSLDDIERLASRM 133
XP_007563498 100 WPIVSTILARHFSPADAAKVHEQLMKDYERSLRQLSLDDIERLAGRL 146
Q19KS6        91 WPQLNQILLKHFSPQDAENVLRRLREDHRKSLQRMNLDDLERISKVL 137 gray short-tailed opossum
XP_004026346  91 WHRLGLVLAKHFEPQDAEAVLQLLRQEHEERLQKISLEHLEQLAQYL 137
XP_004853730  93 WHQLDRVLAKHFGPQDGKMVLQLLRQEHEERLQKVSLEGLEQLACHL 139
ELW65357      89 WHQLGQVLAKPFKPQDAEAVLQLLRQEQEQRLQRISLGDLEQLAQHF 135
XP_001374367  96 WLLVSQILARHFNTADTRRVLEQLQKDYDRSLRLLSLDDIERLATRM 142
XP_006130128  55 WHSLAQVLARHFSPADTQKVLEQLQKDYERSLRLLSLDDIERLATRL 101
XP_012026745  98 WPLISRILAQHFSAADASRVLDQLQRDYERSLSRLTLDDIERLAGRF 144
XP_008702447  86 WHHLGLVLAKHFEPRDSKAVLQLLRREHQERLRRISLGDLEQLAQyl 132 polar bear
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap