3LLM,5AOR


Conserved Protein Domain Family
DEXHc_DHX9
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cd17972: DEXHc_DHX9 
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DEXH-box helicase domain of DEAH-box helicase 9
DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Links
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Statistics
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PSSM-Id: 350730
Aligned: 6 rows
Threshold Bit Score: 439.655
Created: 18-Jul-2017
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Structure:3LLM; Homo sapiens DHX9 with bound Mn.ADP, contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                   #                     
3LLM_A          2 VPWSPPqsNWNPWTSSNIdegplafatpeQISXDLKNELXYQleqdhdlQAILQERElLPVKKFESEILEAISqNSVVII 81   human
5AOR_A        326 IPWAPPqaNWNTWHACNIdegelattsidDLSMDYERSLRDRrqndneyRQFLEFREkLPIAAMRSEILTAINdNPVVII 405  fruit fly
NP_001087383  333 VPWSPPqeNWNPWTSSNIdegplafatqeQISLELKNEHMYHiqd-pniKQVLIDREsLPVKKFEEEIMHAVHnSPVVII 411  African clawe...
NP_001188373  337 VPWSPPqvNWNPWTSSNIdegplafctpeQISNDLLNELNYQleqdqnlQTILTERSqLPVKNFQEQIMSTIYnNPVVII 416  zebrafish
Q08211        330 VPWSPPqsNWNPWTSSNIdegplafatpeQISMDLKNELMYQleqdhdlQAILQERElLPVKKFESEILEAISqNSVVII 409  human
3913436       325 ISWAPPlqNWNPWRASNIdeeplafmsmeQISQRIMEKEDFKrge--alDKITAQRGeLPVAQYRENIVQTVAeNRVTLI 402  Caenorhabditi...

Feature 1            #######                                    #                                 
3LLM_A         82 RGATGCGKTTQVPQFILDDFIqndraaecNIVVTQPRRISAVSVAERVAFErgeepgkSCGYSVRFESILPrphaSIXFC 161  human
5AOR_A        406 RGNTGCGKTTQIAQYILDDYIcsgqggyaNIYVTQPRRISAISVAERVARErceqlgdTVGYSVRFESVFPrpygAILFC 485  fruit fly
NP_001087383  412 RGATGCGKTTQVPQYILDEYIrndraaqcNIVVTQPRRISAVSVAERVAFErgeeigkSCGYSVRFESVLPrphaSMLFC 491  African clawe...
NP_001188373  417 RGATGCGKTTQVPQYILDEFIkggrasdcNIVVTQPRRISAVSVAERVSFErgedvgkSCGYSVRFESFLPrphaSILFC 496  zebrafish
Q08211        410 RGATGCGKTTQVPQFILDDFIqndraaecNIVVTQPRRISAVSVAERVAFErgeepgkSCGYSVRFESILPrphaSIMFC 489  human
3913436       403 KGETGCGKSTQVAQFLLESFLensngasfNAVVSQPRRISAISLAERVANErgeevgeTCGYNVRFDSATPrpygSIMFC 482  Caenorhabditi...

Feature 1                              ##                                                         
3LLM_A        162 TVGVLLRKLeaGIRGiSHVIVDEIHERDintDFLLVVLRDVVQaypeVRIVLXSATidTSXFCEYFfn------cPIIEV 235  human
5AOR_A        486 TVGVLLRKLeaGLRGvSHIIVDEIHERDvnsDFLLVILRDMVDtypdLHVILMSATidTTKFSKYFgi------cPVLEV 559  fruit fly
NP_001087383  492 TVGVLLRKLesGIRGiSHVIVDEIHERDintDFLLVVLRDVIQafpeIRVILMSATidTSMFCEYFfn------cPIIEV 565  African clawe...
NP_001188373  497 TVGVLLRKLesGIRGiSHVIVDEIHERDintDFLLVVLRDVVQaypdVRVILMSATidTTMFKEYFfn------cPVIEV 570  zebrafish
Q08211        490 TVGVLLRKLeaGIRGiSHVIVDEIHERDintDFLLVVLRDVVQaypeVRIVLMSATidTSMFCEYFfn------cPIIEV 563  human
3913436       483 TVGVLLRMMenGLRGiSHVIIDEIHERDvdtDFVLIVLREMIStyrdLRVVLMSATidTDLFTNFFssipdvgptPVITM 562  Caenorhabditi...

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