5VZM,6ASR,6AXD


Conserved Protein Domain Family
Rev1_UBM2
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cd19318: Rev1_UBM2 
Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1
This model characterizes UBM2, the second ubiquitin-binding motif of Rev1, a DNA damage tolerance protein. Rev1 acts as a translesion synthesis (TLS) DNA polymerase and may also recruit other TLS polymerases to the site of DNA damage; in that process the UBMs are essential for Rev1 function, triggering TLS activation via recognition of ubiquitin moieties in PCNA, the proliferating cell nuclear antigen.
Links
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Statistics
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PSSM-Id: 412037
Aligned: 29 rows
Threshold Bit Score: 59.9301
Created: 30-Sep-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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ubiquitin
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:ubiquitin binding interface [polypeptide binding site]
Evidence:
  • Structure:6ASR: UBM2 of human REV1 binds ubiquitin; contacts at 4A
  • Comment:The C-terminal region of Y-family polymerase Rev1 has two canonical ubiquitin-binding motifs (UBMs), which are necessary for the interaction with ubiquitin.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             ###   ### ##  ### ##  #   #     
5VZM_B         76 INLIALPAFSQVDPEVFAALPAELQRELKAAYDQRQ 111  human
6ASR_B         16 INLIALPAFSQVDPEVFAALPAELQRELKAAYDQRQ 51   human
OSD02119      935 QAELDLPSFSQVDMSVFEALPDDVRKELEAEYKRRS 970  Pycnoporus coccineus BRFM310
XP_009553139  864 TSASDLPSFSQVDLSVFNALPADLQEELQAEYTRRS 899  Heterobasidion irregulare TC 32-1
XP_005107801 1323 EDVSALPSFSQLDMDCFEALPAQLQEEIKNEYSRQQ 1358 California sea hare
NP_001084913  912 RFAIEVPSPSQIDPSVLEALPSDIREQVEQTFGFQQ 947  African clawed frog
XP_006001425  945 NVSIEVPSPSQIDPSVLEALPPDIREQVEQTCSVRQ 980  coelacanth
XP_030842612  867 SGHLALPSPSQIDMSVLQELPKDLQEQILESYRGQK 902  Strongylocentrotus purpuratus
XP_002607951  874 HEDLYLPSPSQVDPSVLAALPKDIRQQIEQTYAARN 909  Florida lancelet
XP_006819721  855 DGDLFLPSPSQVDPSVLAALPSDIRQQIEKGYAARN 890  Saccoglossus kowalevskii

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