7L7I


Conserved Protein Domain Family
HSP90

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pfam00183: HSP90 
Hsp90 protein
Statistics
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PSSM-Id: 459703
Aligned: 87 rows
Threshold Bit Score: 438.527
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7L7I_A       196 EYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVsdD---EAEEKEDKEe----eKEKEEKesedkpeIE---DVGsde 265
XP_002185513 240 EYLESSKMQELLQRYSEFIEFPISIWKETTEYKKVpdE---EA-------------NKDLPE-------GE--------- 287
EPB92434     170 rFLQEKNLKELVHKYSQFITFPIMVWSGQEEEVPVseE---DS-------------SSNDDV-------VE---ESI--- 220
CBZ12407     220 qFLSAETIKKTIHQYSEFINFPIYV----QEEVEVa-----STAATPEPAae--egSLDEGA-------VE---EDS--- 275
CDS42723     241 EYLQQDVLRKILKKYSQFVMCPIKLWESQTVNVEEdvE---EEKVD----------LSDDIS-------VE---EE---- 293
EDX14708     257 DFLEEDTVRELIRKYSQFINFPIRMWSSKTVEEEVpvE---EEAKPEKSEdd---vEDEDAK-------VE---EAD--- 317
Q16KZ2       260 DFLEEDTVKQLIKKYSQFINFPIYMWTSKEVEEEVpvE---EEVTEKPEKkdedltEEEDGK-------VE---EEA--- 323 yellow fever mo...
EFA78289     266 EFLNQDTIKSLVKKYSQFINFPISMYVSHQEDAp---E---EETPIDAKPv-----DETEVK-------VEe--EET--- 322
XP_001617311 246 nlMNDKKLVDLISKYSQFIQYPIYLLHENVYTEEVlaDiakEMENDP---------NYDSVK-------VE---ESD--- 303
Q7RE51       265 efSNINKIQTIVEKFSSFINFPVYILNKKQAPLESasA---DNAASADNAv-----NGDNVD-------NAantANA--- 326 Plasmodium yoel...
7L7I_A       266 eeekKDGD-----------KKKKKK-IKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTN-D--WEDH----LAV 326
XP_002185513 288 -------------------EPKMKT-VPETKEGYERVNNQKPIWLRPPREVEEDEYTDFYKSAFRaS--YDDP----MKW 341
EPB92434     221 ----DDDK-----------KGKKKT-EKRMVYGWHHVNVQKPIWMRDPKDITEDDHKEFYKSLTR-E--SSNP----LAW 277
CBZ12407     276 ----DK-------------EGGTQG-VAK-ERRWVLVNENRPIWTRPIGNVTEEEYHKFYKAFSG-D--YRDP----LYF 329
CDS42723     294 -------------------KPKSKKtVEKTVWDWIQLNDLKPIWTKKPSEVAEESYKELFKVLSR-S--SESP----LAH 347
EDX14708     318 ----DE-------------KPKTKK-VSKTTWDWTLINDSKPIWTRKPAEVTEDEYTSFYKSLTK-D--SSEP----LTQ 372
Q16KZ2       324 ----EEE------------KPKTKK-IKKTVWDWEVMNDSKPIWTRKPNDVTDEEYTEFYKSLTK-D--TSDP----LTH 379 yellow fever mo...
EFA78289     323 ----TDEQeeeksliddapKPAEKK--KIDVFDWEIVNDHKPLWVRSPKEITEEEYNEFYKTLSK-G--TENP----LAH 389
XP_001617311 304 ----DP-------------NKKTRT-VEKKVKKWKLMNEQKPIWLRPPKELTDEDYKKFFSVLSG-F--NDEP----LYH 358
Q7RE51       327 ----DN-------------AGESEQ-VQEI-----LINSQKPLWCK--DEVSEEEHKKFFNFLNK-NksYSDEnksyLYK 380 Plasmodium yoel...
7L7I_A       327 KHFSVEGQLEFRALLFVPRRAPF---DLFEN--RKKKNn-IKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISR 400
XP_002185513 342 THFVLEGQVECKALLYIPGMLPF---ELSKDmfDENARn-IRLYVKRVFINDKFEDLMPRWLKFVRGVVDSNDLPLNVSR 417
EPB92434     278 THFKGEGEIEFRTLLYVPPVVND---VFYQNvqKDQSNhpIKLFVKRVFISDEV-DLLPKWLSFLKGIVDADDMPLNVSR 353
CBZ12407     330 SHFKVEGEVDFDSILFVPTTVDP---ASFSDdnAAPNTn-IKLYVRRVFITDEFRDLLPRYLNFVKGIVDSNDLPLNVSR 405
CDS42723     348 IHFSAEGEVSFNAILFISPVPRP---DLFQSd-kLITDn-IKLYVRKVFITENVDEMLPRYLSFVYGIVDSDNLPLNVSR 422
EDX14708     373 THFIAEGEVTFKSLLYVPKVQPS---ESFNRy-gTKSDn-IKLYVRRVFITDEFNDMMPNYLSFIRGVVDSDDLPLNVSR 447
Q16KZ2       380 THFVAEGEVTFKSLLFIPKVQPS---ESFNKy-gTKSDn-IKLYVRRVFITDEFNDMMPNYLNFIRGVVDSDDLPLNVSR 454 yellow fever mo...
EFA78289     390 SHFVTEGDTEFRSIIYIPNTPPA---NLFDp--EAIIDg-LKLFVRRVFITDSMKDLVPSWLRFLQGIIDSDDLPLNVSR 463
XP_001617311 359 IHFFAEGEIEFKCLIYIPSRAPSindHLFT-----KQNs-IKLYVRRVLVADEFVEFLPRYMSFIKGVVDSDDLPLNVSR 432
Q7RE51       381 LMYKTDAPMSIKSVFYIPEEAPS---RLFQ---QNYDId-VSLYCKKVLVKKCADNIIPKWLHFVKGIIDCEDMPLNISR 453 Plasmodium yoel...
7L7I_A       401 EMLQQSKILKVIRKNLVKKCLELFTEL-AEDKEN-----------------------------YKKFYEQFSKNIKLGIH 450
XP_002185513 418 EILQKSKVLSIINKRLVRKSLDMIRDI-EQDEDEg---------------------------qYVMFWNNFGKYLKVGVI 469
EPB92434     354 ETLQKHRSLRIITRHLVKKALDMFTSL-SE-NDPk---------------------------aFAKFLSQYGTILKYGAI 404
CBZ12407     406 EVLQESRILRVIKKKLVRKTLSMFADI-AA-QDEaiadgkqvenpa------lsghthlkkpaYTKFWELYGKHLRLGVM 477
CDS42723     423 EMLQQHKLLKLIKKKLVRKVIEMLQKM-SDED-------------------------------YEKFWKAYSVAVKLGVL 470
EDX14708     448 ETLQQHKLIKVIKKKLVRKVLDMLKKI-DKEA-------------------------------YEKFWKEFSTNIKLGVM 495
Q16KZ2       455 ETLQQHKLIKVIKKKLVRKALDMIKKL-DKET-------------------------------YDKFWKEFSTNIKLGIM 502 yellow fever mo...
EFA78289     464 EILQQHKILKKIKDTLVKKFIKLVQDL-SNNEDKt---------------------------vYQNFYKKYGNNLKFGVI 515
XP_001617311 433 EQLQQNKILKAVSKRIVRKILDTFRTLyTSGKKNkedlraqlaketdeekkkeiqkkinepstYKLIYKEYRKYLKTGCY 512
Q7RE51       454 ESMQDTALMNKLSRIIVTKIIKTLEKE-AS-INEd---------------------------kYLKFYKNFSYNLKEGIL 504 Plasmodium yoel...
7L7I_A       451 EDSQ---NRKKLSELLRYYTS--ASGD--EMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFVERLRKHGLEVIYMIE 523
XP_002185513 470 EDDA---NRKEIAPLLRFFSS--QSGE--EYTSLEKYVEAMPEGQKSIYYVTGDGRENASMSPVIEKLASRGYEVLFATE 542
EPB92434     405 EDQP---YRKKITSLLRFATS--SNTEa-FSSSLDDYIDRAKADQKNIYFMTGSNIAEIEQSPFIESLLARGYEIIYFTD 478
CBZ12407     478 LDSN---NRNRLTKLFRYKSS--RSES--EYISLQTYVDRMKKGQKGIYYLSGDSVARIKKSPVLEDAVNHDVEVIFMTD 550
CDS42723     471 QDAP---NKARLTELLRFYTS--KSED--KLTSFSNYISRMKEGQEHIFYVAGQNIDEVKTSLFVERIKRLGFEVIYFTE 543
EDX14708     496 EDPS---NRSRLAKLLRFQTS--NGKG---VTSLAEYKERMKAKQEHIYYIAGANRAEVEKSPFVERLLSKGYEVLYLVE 567
Q16KZ2       503 EDPS---NRSRLAKLLRFQSS--NSKSskEYTSLSDYVSRMKPKQEHIYFIAGSSRAEVEKTPFAERLLSRGYEVLYLVE 577 yellow fever mo...
EFA78289     516 EETSnthNKNRLIKLLMFPSS--KD----EFTTFENYVSRMKEGQEQIYFISGKSKETLKSSPLIEQALKRGYEVIYMVD 589
XP_001617311 513 EDDI---NRSKIVKLLLFK-T--MLHP--KSISLDTYVENMKPDQKFIYYASGDSYEYLSKIPQLQIFKKKNIDVVFLTE 584
Q7RE51       505 EDSTknmYKNVMLNLLRFYSVnlK-----KYISLNEYVKNFKNTQKNIYYFSANDINIALSSPYMESFKNKQVDVLLLFE 579 Plasmodium yoel...
7L7I_A       524 PIDEYCVQQLKEFEGKTLVSV---TKEG-LEL--P-EDEEEKKKQEE------------------KKTKFENLCKIMKD- 577
XP_002185513 543 PLDEIMMESLRNYKDKDVVDA---AKEN-LNLddS-QDEESKKKKEQ------------------LREEYKQVAEYLET- 598
EPB92434     479 PIDETFVENIPGYNRKQFVNI---AKGD-LTF-----DDDEQDVDQG------------------LEAKFKPLTDWLFD- 530
CBZ12407     551 AIDEYVVSQLTDFAGKKLINL---AKEG-VQF--EeSDARQRVADRK------------------RKEKYDSFFTHLRV- 605
CDS42723     544 PMDEYVMQSLHEVMGKKTQNL---AKAG-LDLklD------KEKFEE------------------QEKLFRPLTDWLKDk 595
EDX14708     568 AVDEYCISALPEFDGKKFQNV---AKEG-FQL--N-ESEKSKKNFES------------------LKSTFEPLVKWLNDv 622
Q16KZ2       578 AVDEYSISALPEFDGKKFQNI---AKEG-FVL--N-ESDEAKAKFDE------------------LKTEFEPLLKWLNDv 632 yellow fever mo...
EFA78289     590 PIDEYLIPQITTYNNKKLTNL---AREG-VKF--E-DAVADEEQEKQ------------------VAEEYKPLTDFLQK- 643
XP_001617311 585 SVDESCVQRVQEYDGKKFKSI---QKGE-ITF--E-LTDDEKKKEEK------------------VKKMYKALIDVISD- 638
Q7RE51       580 EIDEFVLMNLQSYNDSKFVSIdssQKEDlDEIilSnENSDGKNSDGKngddqnsdgknnmnkipfTQDQKIELEKYIKQ- 658 Plasmodium yoel...
7L7I_A       578 ILE-KKVEKVVVSNRLVTSPCCIVTSTYGW-TANMERIMKAQALR---DNSTMGYMAA----KKHLEINPDHSIIETLRQ 648
XP_002185513 599 LLK-GKVQKVVISDQLTDSPAALVQGAYGM-SPTMQRYMRAQSVAsggNGDLPGMN------QAVMEVNPNHPIVRGLDR 670
EPB92434     531 TLY-ESIEKAVISRRLTTSPFAIVAPKTGL-SGHAQRVLDAQGVNh-kNPNMEYILESmrlqKKILEINPNHPVITTLLD 607
CBZ12407     606 LFGySEVRKVILTKRMTNEAFIVSSGENQI-TARLASIMRGQSMSlanQQMTA---------ERVLEVNYRHPLVDEMFK 675
CDS42723     596 GLS-GKIKDAKISQRLESSPCALVADEYMV-SGNFQKVILAQAYAtsdSATNSYYLNQ----KHTLEINPRHPLIKKLNE 669
EDX14708     623 ALK-DQISKAQVSERLSNSPCALVAGVFGW-TGNMERLAMSNAHQksdDPQRTYYLNQ----KKTLEINPRHPLMRELLR 696
Q16KZ2       633 ALK-DKIAKALVSERLSNSPCALVASMFGW-TGNMERLALANAHQktdDPQRQYYLNQ----RKTLEINPRHPLMRELLR 706 yellow fever mo...
EFA78289     644 QLG-KKVEKVVISKILADSPCVLVTNQWGV-TANMERIMKAQSFGnaqEDNYMAMMN-----KKIMEINPDHTLIKQLLS 716
XP_001617311 639 TLR-NQIFKVEISRRLVDAPCAVVSTEWGL-SGQMEKLMKINVN----NADQIKAMSG----QKILEINPDHPIMIDLLK 708
Q7RE51       659 VLG-PKCSDVKFSERLSLSPAVVT----GFlSPTLRRVMKATMKNsdmNDNMLQNL------PATLEINPTHTIIISIYH 727 Plasmodium yoel...
7L7I_A       649 KAEA-DKndKSVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGL--------GIde-dDPTAddt----saaVTE 714
XP_002185513 671 MIKV-DKesTELQDRALLMYDVAAMTSGYEVGDMKSFAARVMGLMDTGV--------GGisdaEIISesptpteteePKM 741
EPB92434     608 YVEEdn-itEEMTNLIQLMYETTAIRSGFPLKDMTQFAGRVEGLIRKAV--------GV-----SILeeakvkvkkaNEK 673
CBZ12407     676 RFTV-DEndEVATDIAWVLYDTANLQAEFPVADVAAYSKRINRLLRSSV--------DLsaddSLLPpddaeytvsdTEA 746
CDS42723     670 LIQI-DPddEVAKENTLLLFDTAVLRSGYIMQDLSGFAERIERELRKNL--------DVdp-dEQVEpdesipsetdSAN 739
EDX14708     697 RVEA-DEadDTAKDMAVMMFRTATLRSGYMLQETSQFADSIEQMMRQTL--------GVsq-dEQVEidedeeddaeETA 766
Q16KZ2       707 RVEA-DSddVVAKDMAVLMFNTATLRSGFQLPETADFADSIERMMRQTL--------GVsq-dEQPEpeefveedsaDAA 776 yellow fever mo...
EFA78289     717 RLNEfGAddEVAKVSAQVLFETSSLSSGYIVENPSNFANWIYKMMEVsg-------------eKIKEasfkveeeeqQQA 783
XP_001617311 709 RSVS-NPkdSQLTESIKIIYQSAKLASGFDLEDTADLAQIVYDHINQKL--------GVdnnlKIDDldpaifetkkMEQ 779
Q7RE51       728 LKNT-Ne--EVAKLLVEQLYDNACIAAGI-LEDPRSLLTKLNELLLLTAryayhyekKTdahsESVDkadaypesvdKAD 803 Plasmodium yoel...
7L7I_A       715 EMPPLE 720
XP_002185513 742 EAKMED 747
EPB92434     674 TEEERK 679
CBZ12407     747 EEEEEQ 752
CDS42723     740 VTEMES 745
EDX14708     767 TGSQES 772
Q16KZ2       777 SQEEEE 782 yellow fever mosquito
EFA78289     784 QEPEVE 789
XP_001617311 780 EDSPDG 785
Q7RE51       804 AHPESV 809 Plasmodium yoelii yoelii
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