"GeneDx"[submitter] AND "SDHC"[gene] - ClinVar - NCBI

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	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 58109	GRCh38/hg38 1q23.1-25.1(chr1:157747246-176021247)x3	ADAMTS4, ADCY10 +775 more	Copy number gain	See cases	GPathogenic
Select item 368837	NM_003001.5(SDHC):c.-38G>A	MPZ, SDHC	Single nucleotide variant	Carney-Stratakis syndrome +11 more	GBenign
Select item 368838	NM_003001.5(SDHC):c.-32T>C	SDHC	Single nucleotide variant	Paragangliomas 3 +3 more	GBenign
Select item 1784205	NM_003001.5(SDHC):c.-1G>A	SDHC	Single nucleotide variant (5 prime UTR variant +1 more)	not provided +1 more	GUncertain significance
Select item 407060	NM_003001.5(SDHC):c.1A>G (p.Met1Val)	SDHC (M1V)	Single nucleotide variant (missense variant +1 more)	not provided +3 more	GPathogenic
Select item 7241	NM_003001.5(SDHC):c.3G>A (p.Met1Ile)	SDHC (M1I)	Single nucleotide variant (missense variant +1 more)	Paragangliomas 3 +2 more	GPathogenic
Select item 407063	NM_003001.5(SDHC):c.7G>A (p.Ala3Thr)	SDHC (A3T)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +4 more	GUncertain significance
Select item 407053	NM_003001.5(SDHC):c.7G>T (p.Ala3Ser)	SDHC (A3S)	Single nucleotide variant (missense variant)	not provided +4 more	GUncertain significance
Select item 161387	NM_003001.5(SDHC):c.8C>T (p.Ala3Val)	SDHC (A3V)	Single nucleotide variant (missense variant)	Paragangliomas 3 +5 more	GUncertain significance
Select item 371802	NM_003001.5(SDHC):c.11T>C (p.Leu4Pro)	SDHC (L4P)	Single nucleotide variant (missense variant)	not provided +4 more	GUncertain significance
Select item 663454	NM_003001.5(SDHC):c.13T>A (p.Leu5Met)	SDHC (L5M)	Single nucleotide variant (missense variant)	Gastrointestinal stromal tumor +3 more	GUncertain significance
Select item 577464	NM_003001.5(SDHC):c.14T>C (p.Leu5Ser)	SDHC (L5S)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +4 more	GUncertain significance
Select item 184591	NM_003001.5(SDHC):c.15G>T (p.Leu5Phe)	SDHC (L5F)	Single nucleotide variant (missense variant)	not provided +4 more	GUncertain significance
Select item 546054	NM_003001.5(SDHC):c.17_18dup (p.Arg7Ter)	SDHC (R7* +1 more)	Duplication (frameshift variant +1 more)	not provided +2 more	GPathogenic
Select item 957116	NM_003001.5(SDHC):c.20+5C>T	SDHC	Single nucleotide variant (5 prime UTR variant +1 more)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 44647	NM_003001.3(SDHC):c.20+11_20+12dup	MPZ, SDHC	Duplication (5 prime UTR variant +1 more)	Charcot-Marie-Tooth, Intermediate +9 more	GBenign
Select item 811691	NM_003001.5(SDHC):c.20+11_20+12insTG	SDHC	Insertion (5 prime UTR variant +1 more)	not provided	GBenign
Select item 512130	NM_003001.5(SDHC):c.20+12_20+13insTA	SDHC	Insertion (5 prime UTR variant +1 more)	not specified +2 more	GLikely benign
Select item 677078	NM_003001.5(SDHC):c.20+82T>C	SDHC	Single nucleotide variant (5 prime UTR variant +1 more)	not provided	GBenign
Select item 1273270	NM_003001.5(SDHC):c.20+311C>T	SDHC	Single nucleotide variant (5 prime UTR variant +1 more)	not provided	GBenign
Select item 1281321	NM_003001.5(SDHC):c.21-211C>T	SDHC	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1282237	NM_003001.5(SDHC):c.21-189A>G	SDHC	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1290940	NM_003001.5(SDHC):c.21-96C>T	SDHC	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 293316	NM_003001.5(SDHC):c.21-10dup	SDHC	Duplication (intron variant)	Hereditary cancer-predisposing syndrome +2 more	GConflicting classifications of pathogenicity
Select item 239451	NM_003001.5(SDHC):c.25G>A (p.Val9Ile)	SDHC (V9I)	Single nucleotide variant (missense variant +3 more)	Paragangliomas 3 +3 more	GUncertain significance
Select item 1010940	NM_003001.5(SDHC):c.29G>C (p.Gly10Ala)	SDHC (G10A)	Single nucleotide variant (missense variant +3 more)	Paragangliomas 3 +2 more	GUncertain significance
Select item 239454	NM_003001.5(SDHC):c.32G>A (p.Arg11His)	SDHC (R11H)	Single nucleotide variant (missense variant +3 more)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 187333	NM_003001.5(SDHC):c.32G>T (p.Arg11Leu)	SDHC (R11L)	Single nucleotide variant (missense variant +3 more)	Hereditary cancer-predisposing syndrome +4 more	GUncertain significance
Select item 439297	NM_003001.5(SDHC):c.40C>T (p.Leu14Phe)	SDHC (L14F)	Single nucleotide variant (missense variant +3 more)	not specified +5 more	GUncertain significance
Select item 534380	NM_003001.5(SDHC):c.42C>T (p.Leu14=)	SDHC	Single nucleotide variant (synonymous variant +3 more)	Gastrointestinal stromal tumor +4 more	GConflicting classifications of pathogenicity
Select item 1386907	NM_003001.5(SDHC):c.43C>G (p.Arg15Gly)	SDHC (R15G)	Single nucleotide variant (intron variant +3 more)	Gastrointestinal stromal tumor +3 more	GUncertain significance
Select item 41776	NM_003001.5(SDHC):c.43C>T (p.Arg15Ter)	SDHC (R15*)	Single nucleotide variant (nonsense +3 more)	Hereditary pheochromocytoma-paraganglioma +4 more	GPathogenic
Select item 515256	NM_003001.5(SDHC):c.48C>G (p.Ala16=)	SDHC	Single nucleotide variant (synonymous variant +3 more)	not specified +4 more	GLikely benign
Select item 2500560	NM_003001.5(SDHC):c.56G>T (p.Ser19Ile)	SDHC (S19I)	Single nucleotide variant (missense variant +3 more)	not provided	GUncertain significance
Select item 1313634	NM_003001.5(SDHC):c.59C>G (p.Pro20Arg)	SDHC (P20R)	Single nucleotide variant (missense variant +3 more)	not provided +1 more	GUncertain significance
Select item 480864	NM_003001.5(SDHC):c.61C>G (p.Gln21Glu)	SDHC (Q21E)	Single nucleotide variant (missense variant +3 more)	Hereditary pheochromocytoma-paraganglioma +4 more	GUncertain significance
Select item 465978	NM_003001.5(SDHC):c.64C>T (p.Leu22Phe)	SDHC (L22F)	Single nucleotide variant (missense variant +3 more)	not provided +3 more	GUncertain significance
Select item 1296256	NM_003001.5(SDHC):c.77+26_77+27insAT	SDHC	Insertion (intron variant)	not provided	GBenign
Select item 1227790	NM_003001.5(SDHC):c.77+28_77+33del	SDHC	Deletion (intron variant)	not provided	GBenign
Select item 1207097	NM_003001.5(SDHC):c.77+29_77+31dup	SDHC	Duplication (intron variant)	not provided	GLikely benign
Select item 810854	NM_003001.5(SDHC):c.77+32A>T	SDHC	Single nucleotide variant (intron variant)	not specified +1 more	GBenign/Likely benign
Select item 440260	NM_003001.5(SDHC):c.77+36T>A	SDHC	Single nucleotide variant (intron variant)	not specified +1 more	GBenign
Select item 1180360	NM_003001.5(SDHC):c.77+48C>T	SDHC	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1292800	NM_003001.5(SDHC):c.77+182C>T	SDHC	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1292225	NM_003001.5(SDHC):c.77+186T>C	SDHC	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1280009	NM_003001.5(SDHC):c.77+248G>A	SDHC	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1268314	NM_003001.5(SDHC):c.77+344T>C	SDHC	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 679697	NM_003001.5(SDHC):c.77+428T>G	SDHC	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 679698	NM_003001.5(SDHC):c.77+519A>G	SDHC	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1273176	NM_003001.5(SDHC):c.78-283A>C	SDHC	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1251208	NM_003001.5(SDHC):c.78-193T>C	SDHC	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 676871	NM_003001.5(SDHC):c.78-152C>T	SDHC	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 388960	NM_003001.5(SDHC):c.78-19C>T	SDHC	Single nucleotide variant (intron variant)	Paragangliomas 3 +2 more	GLikely benign
Select item 1722989	NM_003001.5(SDHC):c.78-2A>G	SDHC	Single nucleotide variant (splice acceptor variant +1 more)	not provided +2 more	GLikely pathogenic
Select item 938758	NM_003001.5(SDHC):c.82G>C (p.Val28Leu)	SDHC (V28L +1 more)	Single nucleotide variant (missense variant +3 more)	not provided +2 more	GUncertain significance
Select item 239458	NM_003001.5(SDHC):c.85C>G (p.Pro29Ala)	SDHC (P29A +1 more)	Single nucleotide variant (missense variant +3 more)	Hereditary cancer-predisposing syndrome +5 more	GUncertain significance
Select item 857731	NM_003001.5(SDHC):c.98C>A (p.Thr33Lys)	SDHC (T33K +1 more)	Single nucleotide variant (missense variant +3 more)	not provided +2 more	GUncertain significance
Select item 407054	NM_003001.5(SDHC):c.98C>T (p.Thr33Met)	SDHC (T33M +1 more)	Single nucleotide variant (missense variant +3 more)	Gastrointestinal stromal tumor +5 more	GUncertain significance
Select item 486428	NM_003001.5(SDHC):c.99G>A (p.Thr33=)	SDHC	Single nucleotide variant (synonymous variant +3 more)	not provided +4 more	GConflicting classifications of pathogenicity
Select item 534374	NM_003001.5(SDHC):c.118C>T (p.Arg40Trp)	SDHC (R40W +2 more)	Single nucleotide variant (missense variant +2 more)	Gastrointestinal stromal tumor +4 more	GUncertain significance
Select item 239446	NM_003001.5(SDHC):c.119G>A (p.Arg40Gln)	SDHC (R40Q +2 more)	Single nucleotide variant (missense variant +2 more)	Paragangliomas 3 +3 more	GUncertain significance
Select item 239447	NM_003001.5(SDHC):c.120G>A (p.Arg40=)	SDHC	Single nucleotide variant (synonymous variant +2 more)	Paragangliomas 3 +5 more	GBenign/Likely benign
Select item 580721	NM_003001.5(SDHC):c.136A>G (p.Ile46Val)	SDHC (I46V +2 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 135194	NM_003001.5(SDHC):c.148C>T (p.Arg50Cys)	SDHC (R50C +2 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome +4 more	GConflicting classifications of pathogenicity
Select item 465962	NM_003001.5(SDHC):c.160C>A (p.Pro54Thr)	SDHC (P54T +2 more)	Single nucleotide variant (missense variant +2 more)	Gastrointestinal stromal tumor +3 more	GConflicting classifications of pathogenicity
Select item 239449	NM_003001.5(SDHC):c.164A>G (p.His55Arg)	SDHC (H55R +2 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 534375	NM_003001.5(SDHC):c.166A>C (p.Ile56Leu)	SDHC (I56L +2 more)	Single nucleotide variant (missense variant +2 more)	not provided +3 more	GUncertain significance
Select item 372501	NM_003001.5(SDHC):c.179+1G>C	SDHC	Single nucleotide variant (splice donor variant +1 more)	Paragangliomas 3 +4 more	GLikely pathogenic
Select item 1264999	NM_003001.5(SDHC):c.180-313C>T	SDHC	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1266266	NM_003001.5(SDHC):c.180-289_180-288del	SDHC	Deletion (intron variant)	not provided	GBenign
Select item 1252906	NM_003001.5(SDHC):c.180-288del	SDHC	Deletion (intron variant)	not provided	GBenign
Select item 1234507	NM_003001.5(SDHC):c.180-241_180-240insCTTTG	SDHC	Insertion (intron variant)	not provided	GBenign
Select item 1183924	NM_003001.5(SDHC):c.180-135G>A	SDHC	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 1249430	NM_003001.5(SDHC):c.180-98G>A	SDHC	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1331275	NM_003001.5(SDHC):c.180-3C>T	SDHC	Single nucleotide variant (intron variant)	Paragangliomas 3 +2 more	GUncertain significance
Select item 653952	NM_003001.5(SDHC):c.214C>T (p.Arg72Cys)	SDHC (R19C +5 more)	Single nucleotide variant (missense variant)	Paragangliomas 3 +3 more	GConflicting classifications of pathogenicity
Select item 407044	NM_003001.5(SDHC):c.215G>A (p.Arg72His)	SDHC (R72H +5 more)	Single nucleotide variant (missense variant)	Hereditary pheochromocytoma-paraganglioma +4 more	GConflicting classifications of pathogenicity
Select item 407055	NM_003001.5(SDHC):c.220A>G (p.Thr74Ala)	SDHC (T74A +5 more)	Single nucleotide variant (missense variant)	Hereditary pheochromocytoma-paraganglioma +5 more	GUncertain significance
Select item 465964	NM_003001.5(SDHC):c.221C>T (p.Thr74Ile)	SDHC (T74I +5 more)	Single nucleotide variant (missense variant)	Gastrointestinal stromal tumor +3 more	GUncertain significance
Select item 1223753	NM_003001.5(SDHC):c.241+74C>T	SDHC	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 679696	NM_003001.5(SDHC):c.241+274C>T	SDHC	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1232935	NM_003001.5(SDHC):c.242-193A>G	SDHC	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1204921	NM_003001.5(SDHC):c.242-176T>C	SDHC	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 1267855	NM_003001.5(SDHC):c.242-174T>C	SDHC	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1230554	NM_003001.5(SDHC):c.242-154A>C	SDHC	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1179769	NM_003001.5(SDHC):c.242-136G>T	SDHC	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1362971	NM_003001.5(SDHC):c.242-6C>A	SDHC	Single nucleotide variant (intron variant)	Paragangliomas 3 +2 more	GUncertain significance
Select item 821264	NM_003001.5(SDHC):c.242G>T (p.Gly81Val)	SDHC (G47V +7 more)	Single nucleotide variant (missense variant +2 more)	Gastrointestinal stromal tumor +3 more	GUncertain significance
Select item 654515	NM_003001.5(SDHC):c.259A>C (p.Met87Leu)	SDHC (M34L +7 more)	Single nucleotide variant (missense variant +2 more)	Gastrointestinal stromal tumor +4 more	GConflicting classifications of pathogenicity
Select item 407056	NM_003001.5(SDHC):c.263C>T (p.Ser88Leu)	SDHC (S88L +7 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome +3 more	GConflicting classifications of pathogenicity
Select item 141883	NM_003001.5(SDHC):c.292T>G (p.Ser98Ala)	SDHC (S98A +7 more)	Single nucleotide variant (missense variant +2 more)	Gastrointestinal stromal tumor +4 more	GUncertain significance
Select item 239453	NM_003001.5(SDHC):c.295T>C (p.Tyr99His)	SDHC (Y99H +7 more)	Single nucleotide variant (missense variant +2 more)	Paragangliomas 3 +4 more	GConflicting classifications of pathogenicity
Select item 571588	NM_003001.5(SDHC):c.329C>T (p.Pro110Leu)	SDHC (P110L +7 more)	Single nucleotide variant (missense variant +2 more)	not provided +2 more	GUncertain significance
Select item 823723	NM_003001.5(SDHC):c.339C>T (p.Ile113=)	SDHC	Single nucleotide variant (synonymous variant +2 more)	Paragangliomas 3 +3 more	GConflicting classifications of pathogenicity
Select item 414252	NM_003001.5(SDHC):c.342C>T (p.His114=)	SDHC	Single nucleotide variant (synonymous variant +2 more)	Hereditary cancer-predisposing syndrome +4 more	GBenign/Likely benign
Select item 806263	NM_003001.5(SDHC):c.350A>G (p.Lys117Arg)	SDHC (K83R +7 more)	Single nucleotide variant (missense variant +2 more)	not provided +3 more	GUncertain significance
Select item 165182	NM_003001.5(SDHC):c.354T>C (p.Phe118=)	SDHC	Single nucleotide variant (synonymous variant +2 more)	not specified +4 more	GBenign/Likely benign
Select item 841499	NM_003001.5(SDHC):c.367C>T (p.Pro123Ser)	SDHC (P89S +7 more)	Single nucleotide variant (missense variant +2 more)	not provided +4 more	GUncertain significance
Select item 759020	NM_003001.5(SDHC):c.372C>A (p.Leu124=)	SDHC	Single nucleotide variant (synonymous variant +2 more)	Hereditary pheochromocytoma-paraganglioma +4 more	GConflicting classifications of pathogenicity
Select item 428933	NM_003001.5(SDHC):c.377A>G (p.Tyr126Cys)	SDHC (Y126C +7 more)	Single nucleotide variant (missense variant +2 more)	Gastrointestinal stromal tumor +4 more	GPathogenic/Likely pathogenic

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