"KCCC/NGS Laboratory, Kuwait Cancer Control Center"[submitter] AND "AP - ClinVar

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Items: 72

	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 135683	NM_000038.6(APC):c.120G>A (p.Glu40=)	APC	Single nucleotide variant (synonymous variant +2 more)	not provided +4 more	GBenign/Likely benign
Select item 82873	NM_000038.6(APC):c.136-53T>C	APC	Single nucleotide variant (intron variant)	Familial adenomatous polyposis 1 +1 more	GBenign
Select item 490238	NM_000038.6(APC):c.220+4G>A	APC	Single nucleotide variant (intron variant)	Hereditary cancer-predisposing syndrome +2 more	GConflicting classifications of pathogenicity
Select item 217948	NM_000038.6(APC):c.221-29G>C	APC	Single nucleotide variant (intron variant)	Familial adenomatous polyposis 1 +2 more	GLikely benign
Select item 135691	NM_000038.6(APC):c.259C>T (p.Leu87=)	APC	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome +4 more	GBenign/Likely benign
Select item 217981	NM_000038.6(APC):c.423-17T>A	APC	Single nucleotide variant (intron variant)	Familial adenomatous polyposis 1 +3 more	GBenign/Likely benign
Select item 82911	NM_000038.6(APC):c.423-16A>T	APC	Single nucleotide variant (intron variant)	not specified +2 more	GBenign/Likely benign
Select item 135710	NM_000038.6(APC):c.597G>A (p.Ala199=)	APC	Single nucleotide variant (synonymous variant +1 more)	Classic or attenuated familial adenomatous polyposis +3 more	GBenign/Likely benign
Select item 218001	NM_000038.6(APC):c.645+32C>T	APC	Single nucleotide variant (intron variant)	Familial adenomatous polyposis 1 +2 more	GBenign
Select item 218002	NM_000038.6(APC):c.645+61C>T	APC	Single nucleotide variant (intron variant)	Familial adenomatous polyposis 1	GBenign
Select item 92349	NM_000038.6(APC):c.705A>G (p.Leu235=)	APC	Single nucleotide variant (synonymous variant +2 more)	Familial adenomatous polyposis 1	GBenign FDA Recognized database
Select item 492653	NM_000038.6(APC):c.729+23T>C	APC	Single nucleotide variant (intron variant)	Familial adenomatous polyposis 1 +2 more	GBenign/Likely benign
Select item 218006	NM_000038.6(APC):c.730-29A>T	APC	Single nucleotide variant (intron variant)	Familial adenomatous polyposis 1 +2 more	GBenign
Select item 218005	NM_000038.6(APC):c.730-22G>C	APC	Single nucleotide variant (intron variant)	Familial adenomatous polyposis 1 +1 more	GLikely benign
Select item 185590	NM_000038.6(APC):c.759C>G (p.Gly253=)	APC	Single nucleotide variant (synonymous variant +1 more)	Familial adenomatous polyposis 1 +2 more	GConflicting classifications of pathogenicity
Select item 411556	NM_000038.6(APC):c.775C>T (p.Arg259Trp)	APC (R241W +5 more)	Single nucleotide variant (missense variant +1 more)	Classic or attenuated familial adenomatous polyposis +4 more	GConflicting classifications of pathogenicity
Select item 218009	NM_000038.6(APC):c.835-24A>T	APC	Single nucleotide variant (intron variant)	Familial adenomatous polyposis 1 +1 more	GLikely benign
Select item 372069	NM_000038.6(APC):c.835-20A>G	APC	Single nucleotide variant (intron variant)	Familial adenomatous polyposis 1 +1 more	GLikely benign
Select item 254733	NM_000038.6(APC):c.933+30A>G	APC	Single nucleotide variant (intron variant)	not provided +2 more	GBenign/Likely benign
Select item 231924	NM_000038.6(APC):c.1240C>A (p.Arg414Ser)	APC (R396S +10 more)	Single nucleotide variant (missense variant)	Familial adenomatous polyposis 1 +2 more	GUncertain significance
Select item 82574	NM_000038.6(APC):c.1408+792A>T	APC	Single nucleotide variant (intron variant)	Familial adenomatous polyposis 1 +1 more	GBenign
Select item 42238	NM_000038.6(APC):c.1458T>C (p.Tyr486=)	APC	Single nucleotide variant (synonymous variant)	Familial adenomatous polyposis 1	GBenign FDA Recognized database
Select item 135685	NM_000038.6(APC):c.1554G>A (p.Thr518=)	APC	Single nucleotide variant (synonymous variant)	Classic or attenuated familial adenomatous polyposis +4 more	GBenign/Likely benign
Select item 141366	NM_000038.6(APC):c.1564A>G (p.Met522Val)	APC (M504V +12 more)	Single nucleotide variant (missense variant)	Classic or attenuated familial adenomatous polyposis +2 more	GUncertain significance
Select item 42239	NM_000038.6(APC):c.1635G>A (p.Ala545=)	APC	Single nucleotide variant (synonymous variant)	Familial adenomatous polyposis 1	GBenign FDA Recognized database
Select item 217935	NM_000038.6(APC):c.1658G>A (p.Trp553Ter)	APC (W535* +12 more)	Single nucleotide variant (nonsense)	Familial adenomatous polyposis 1 +2 more	GPathogenic
Select item 807	NM_000038.6(APC):c.1660C>T (p.Arg554Ter)	APC (R554* +12 more)	Single nucleotide variant (nonsense)	Hepatocellular carcinoma +8 more	GPathogenic
Select item 183766	NM_000038.6(APC):c.1695A>G (p.Glu565=)	APC	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +4 more	GBenign
Select item 383468	NM_000038.6(APC):c.1744-14C>A	APC	Single nucleotide variant (intron variant)	Classic or attenuated familial adenomatous polyposis +3 more	GConflicting classifications of pathogenicity
Select item 428125	NM_000038.6(APC):c.1958+1G>A	APC	Single nucleotide variant (splice donor variant)	not provided +2 more	GPathogenic
Select item 82616	NM_000038.6(APC):c.1958+8T>C	APC	Single nucleotide variant (intron variant)	Familial adenomatous polyposis 1 +4 more	GBenign
Select item 133524	NM_000038.6(APC):c.1959G>A (p.Arg653=)	APC	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +5 more	GBenign/Likely benign
Select item 236569	NM_000038.6(APC):c.2031C>T (p.Val677=)	APC	Single nucleotide variant (synonymous variant)	Classic or attenuated familial adenomatous polyposis +4 more	GBenign/Likely benign
Select item 135687	NM_000038.6(APC):c.2262T>G (p.Val754=)	APC	Single nucleotide variant (synonymous variant)	not specified +4 more	GBenign/Likely benign
Select item 133517	NM_000038.6(APC):c.2586C>G (p.Asn862Lys)	APC (N844K +12 more)	Single nucleotide variant (missense variant)	not specified +5 more	GBenign/Likely benign
Select item 41500	NM_000038.6(APC):c.2608C>T (p.Pro870Ser)	APC (P870S +12 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +5 more	GBenign/Likely benign
Select item 132763	NM_000038.6(APC):c.3165A>T (p.Ile1055=)	APC	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +5 more	GBenign/Likely benign
Select item 88913	NM_000038.6(APC):c.3183_3187del (p.Lys1061_Gln1062insTer)	APC	Deletion (frameshift variant +1 more)	not provided +5 more	GPathogenic
Select item 823623	NM_000038.6(APC):c.3336_3340del (p.Asn1113fs)	APC (N1022fs +12 more)	Deletion (frameshift variant)	Familial adenomatous polyposis 1 +1 more	GPathogenic
Select item 133518	NM_000038.6(APC):c.3511C>T (p.Arg1171Cys)	APC (R1153C +12 more)	Single nucleotide variant (missense variant)	Gastric adenocarcinoma and proximal polyposis of the stomach +9 more	GBenign/Likely benign
Select item 183767	NM_000038.6(APC):c.3732A>G (p.Gln1244=)	APC	Single nucleotide variant (synonymous variant)	Familial adenomatous polyposis 1 +4 more	GBenign
Select item 469940	NM_000038.6(APC):c.3795A>G (p.Glu1265=)	APC	Single nucleotide variant (synonymous variant)	Familial adenomatous polyposis 1 +2 more	GBenign/Likely benign
Select item 822	NM_000038.6(APC):c.3920T>A (p.Ile1307Lys)	APC (I1307K +12 more)	Single nucleotide variant (missense variant)	Familial adenomatous polyposis 1 +8 more	GConflicting classifications of pathogenicity; association; risk factor
Select item 816	NM_000038.6(APC):c.3927_3931del (p.Glu1309fs)	APC (E1149fs +12 more)	Microsatellite (frameshift variant)	Familial adenomatous polyposis 1 +1 more	GPathogenic OOncogenic FDA Recognized database
Select item 132705	NM_000038.6(APC):c.4326T>A (p.Pro1442=)	APC	Single nucleotide variant (synonymous variant)	not specified +9 more	GBenign/Likely benign
Select item 1070412	NM_000038.6(APC):c.4333dup (p.Thr1445fs)	APC (T1162fs +12 more)	Duplication (frameshift variant)	Familial adenomatous polyposis 1 +1 more	GPathogenic
Select item 42242	NM_000038.6(APC):c.4479G>A (p.Thr1493=)	APC	Single nucleotide variant (synonymous variant)	Gastric cancer +9 more	GBenign
Select item 183857	NM_000038.6(APC):c.4669_4670del (p.Thr1556_Ile1557insTer)	APC	Deletion (nonsense)	Hereditary cancer-predisposing syndrome +2 more	GPathogenic
Select item 132688	NM_000038.6(APC):c.4893T>C (p.Ser1631=)	APC	Single nucleotide variant (synonymous variant)	not provided +4 more	GBenign/Likely benign
Select item 42243	NM_000038.6(APC):c.5034G>A (p.Gly1678=)	APC	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +4 more	GBenign
Select item 136410	NM_000038.6(APC):c.5250C>G (p.Val1750=)	APC	Single nucleotide variant (synonymous variant)	not specified +4 more	GBenign
Select item 140893	NM_000038.6(APC):c.5257G>C (p.Ala1753Pro)	APC (A1735P +12 more)	Single nucleotide variant (missense variant)	Familial adenomatous polyposis 1 +2 more	GConflicting classifications of pathogenicity
Select item 439411	NM_000038.6(APC):c.5265_5268delinsATCG (p.Ala1755_Ser1756=)	APC	Indel (synonymous variant +1 more)	Hepatocellular carcinoma +6 more	GBenign/Likely benign
Select item 42245	NM_000038.6(APC):c.5268T>G (p.Ser1756=)	APC	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +4 more	GBenign
Select item 184535	NM_000038.6(APC):c.5271T>C (p.Ser1757=)	APC	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +4 more	GBenign/Likely benign
Select item 825724	NM_000038.6(APC):c.5425A>G (p.Lys1809Glu)	APC (K1526E +12 more)	Single nucleotide variant (missense variant)	Familial adenomatous polyposis 1 +1 more	GUncertain significance
Select item 21030	NM_000038.6(APC):c.5465T>A (p.Val1822Asp)	APC (V1804D +12 more)	Single nucleotide variant (missense variant)	Familial adenomatous polyposis 1	GBenign FDA Recognized database
Select item 416716	NM_000038.6(APC):c.5541G>A (p.Thr1847=)	APC	Single nucleotide variant (synonymous variant)	Classic or attenuated familial adenomatous polyposis +3 more	GBenign/Likely benign
Select item 184255	NM_000038.6(APC):c.5790A>G (p.Gln1930=)	APC	Single nucleotide variant (synonymous variant)	Familial adenomatous polyposis 1 +4 more	GBenign/Likely benign
Select item 416743	NM_000038.6(APC):c.5823A>G (p.Pro1941=)	APC	Single nucleotide variant (synonymous variant)	Classic or attenuated familial adenomatous polyposis +3 more	GBenign/Likely benign
Select item 42247	NM_000038.6(APC):c.5880G>A (p.Pro1960=)	APC	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +4 more	GBenign
Select item 391099	NM_000038.6(APC):c.6276A>G (p.Leu2092=)	APC	Single nucleotide variant (synonymous variant)	not provided +3 more	GBenign/Likely benign
Select item 490333	NM_000038.6(APC):c.6347A>G (p.His2116Arg)	APC (H2098R +12 more)	Single nucleotide variant (missense variant)	Familial adenomatous polyposis 1 +2 more	GUncertain significance
Select item 183971	NM_000038.6(APC):c.6387G>A (p.Ser2129=)	APC	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +5 more	GBenign/Likely benign
Select item 184071	NM_000038.6(APC):c.6510A>C (p.Pro2170=)	APC	Single nucleotide variant (synonymous variant)	Familial adenomatous polyposis 1 +3 more	GBenign/Likely benign
Select item 230394	NM_000038.6(APC):c.6948A>G (p.Pro2316=)	APC	Single nucleotide variant (synonymous variant)	Classic or attenuated familial adenomatous polyposis +4 more	GBenign/Likely benign
Select item 42249	NM_000038.6(APC):c.7201C>T (p.Leu2401=)	APC	Single nucleotide variant (synonymous variant)	APC-Associated Polyposis Disorders +5 more	GBenign
Select item 41514	NM_000038.6(APC):c.7504G>A (p.Gly2502Ser)	APC (G2502S +12 more)	Single nucleotide variant (missense variant)	not specified +5 more	GBenign
Select item 482240	NM_000038.6(APC):c.7541C>G (p.Thr2514Ser)	APC (T2514S +12 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +3 more	GConflicting classifications of pathogenicity
Select item 42250	NM_000038.6(APC):c.7704A>G (p.Gly2568=)	APC	Single nucleotide variant (synonymous variant)	not provided +4 more	GBenign
Select item 41516	NM_000038.6(APC):c.7862C>G (p.Ser2621Cys)	APC (S2621C +12 more)	Single nucleotide variant (missense variant)	Familial adenomatous polyposis 1	GBenign FDA Recognized database
Select item 184254	NM_000038.6(APC):c.8043G>C (p.Pro2681=)	APC	Single nucleotide variant (synonymous variant)	Familial adenomatous polyposis 1 +3 more	GBenign/Likely benign

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Items: 72