"KCCC/NGS Laboratory, Kuwait Cancer Control Center"[submitter] AND "MS - ClinVar

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Items: 55

	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 89164	NM_000179.3(MSH6):c.-8C>T	MSH6	Single nucleotide variant (5 prime UTR variant)	not provided +4 more	GConflicting classifications of pathogenicity
Select item 36581	NM_000179.3(MSH6):c.116G>A (p.Gly39Glu)	MSH6 (G39E)	Single nucleotide variant (missense variant +1 more)	Lynch syndrome	GBenign
Select item 36584	NM_000179.3(MSH6):c.186C>A (p.Arg62=)	MSH6	Single nucleotide variant (synonymous variant +1 more)	Lynch syndrome	GBenign
Select item 455161	NM_000179.3(MSH6):c.189C>T (p.Ser63=)	MSH6	Single nucleotide variant (synonymous variant +1 more)	Lynch syndrome 5 +4 more	GLikely benign
Select item 89295	NM_000179.3(MSH6):c.260+22C>G	LOC129933707, MSH6	Single nucleotide variant (intron variant)	Lynch syndrome	GBenign
Select item 89301	NM_000179.3(MSH6):c.261-36A>G	MSH6	Single nucleotide variant (intron variant)	Lynch syndrome	GBenign
Select item 36587	NM_000179.3(MSH6):c.276A>G (p.Pro92=)	MSH6	Single nucleotide variant (synonymous variant +2 more)	Lynch syndrome	GBenign
Select item 89522	NM_000179.3(MSH6):c.457+13A>G	MSH6	Single nucleotide variant (intron variant)	Lynch syndrome	GLikely benign
Select item 89526	NM_000179.3(MSH6):c.457+52T>A	MSH6	Single nucleotide variant (intron variant)	Lynch syndrome	GBenign
Select item 36597	NM_000179.3(MSH6):c.540T>C (p.Asp180=)	MSH6	Single nucleotide variant (synonymous variant +2 more)	Lynch syndrome	GBenign
Select item 479889	NM_000179.3(MSH6):c.556G>A (p.Asp186Asn)	MSH6 (D186N)	Single nucleotide variant (missense variant +2 more)	not provided +3 more	GUncertain significance
Select item 36599	NM_000179.3(MSH6):c.642C>T (p.Tyr214=)	MSH6	Single nucleotide variant (synonymous variant +1 more)	Lynch syndrome	GBenign
Select item 89551	NM_000179.3(MSH6):c.660A>C (p.Glu220Asp)	MSH6 (E220D +1 more)	Single nucleotide variant (missense variant +1 more)	Lynch syndrome	GLikely benign
Select item 220143	NM_000179.3(MSH6):c.733A>T (p.Ile245Leu)	MSH6 (I245L +1 more)	Single nucleotide variant (missense variant +1 more)	Lynch syndrome 5 +4 more	GConflicting classifications of pathogenicity
Select item 138256	NM_000179.3(MSH6):c.984C>T (p.Ser328=)	MSH6	Single nucleotide variant (synonymous variant)	Lynch syndrome +6 more	GBenign/Likely benign
Select item 3256612	NM_000179.3(MSH6):c.1046A>T (p.Gln349Leu)	MSH6 (Q174L +8 more)	Single nucleotide variant (missense variant +2 more)	Lynch syndrome 5	GUncertain significance
Select item 42467	NM_000179.3(MSH6):c.1164C>T (p.His388=)	MSH6	Single nucleotide variant (synonymous variant)	Lynch syndrome	GBenign
Select item 391653	NM_000179.3(MSH6):c.1339C>T (p.Leu447=)	MSH6	Single nucleotide variant (synonymous variant)	Lynch syndrome 5 +3 more	GLikely benign
Select item 36583	NM_000179.3(MSH6):c.1345C>T (p.Leu449=)	MSH6	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +6 more	GBenign
Select item 455142	NM_000179.3(MSH6):c.1510A>C (p.Lys504Gln)	MSH6 (K504Q +2 more)	Single nucleotide variant (missense variant)	Malignant tumor of prostate +2 more	GUncertain significance
Select item 485861	NM_000179.3(MSH6):c.1658C>G (p.Thr553Ser)	MSH6 (T553S +2 more)	Single nucleotide variant (missense variant)	Hereditary nonpolyposis colorectal neoplasms +5 more	GUncertain significance
Select item 578579	NM_000179.3(MSH6):c.1990T>G (p.Ser664Ala)	MSH6 (S664A +2 more)	Single nucleotide variant (missense variant)	Hereditary nonpolyposis colorectal neoplasms +2 more	GUncertain significance
Select item 89251	NM_000179.3(MSH6):c.2092C>G (p.Gln698Glu)	MSH6 (Q698E +2 more)	Single nucleotide variant (missense variant)	Hereditary nonpolyposis colorectal neoplasms +5 more	GConflicting classifications of pathogenicity
Select item 416134	NM_000179.3(MSH6):c.2103A>G (p.Leu701=)	MSH6	Single nucleotide variant (synonymous variant)	Hereditary nonpolyposis colorectal neoplasms +5 more	GBenign/Likely benign
Select item 36585	NM_000179.3(MSH6):c.2253T>C (p.Asn751=)	MSH6	Single nucleotide variant (synonymous variant)	Lynch syndrome	GBenign
Select item 42468	NM_000179.3(MSH6):c.2272C>T (p.Leu758=)	MSH6	Single nucleotide variant (synonymous variant)	Lynch syndrome	GBenign
Select item 140836	NM_000179.3(MSH6):c.2281A>G (p.Arg761Gly)	MSH6 (R761G +2 more)	Single nucleotide variant (missense variant)	Lynch syndrome +6 more	GConflicting classifications of pathogenicity
Select item 455199	NM_000179.3(MSH6):c.2415C>T (p.Ile805=)	MSH6	Single nucleotide variant (synonymous variant)	Lynch syndrome 5 +3 more	GLikely benign
Select item 231388	NM_000179.3(MSH6):c.2493C>T (p.Pro831=)	MSH6	Single nucleotide variant (synonymous variant)	Hereditary nonpolyposis colorectal neoplasms +3 more	GLikely benign
Select item 419929	NM_000179.3(MSH6):c.2534A>G (p.Tyr845Cys)	MSH6 (Y845C +2 more)	Single nucleotide variant (missense variant)	Hereditary nonpolyposis colorectal neoplasms +3 more	GUncertain significance
Select item 657525	NM_000179.3(MSH6):c.2570A>G (p.Asp857Gly)	MSH6 (D555G +2 more)	Single nucleotide variant (missense variant)	Lynch syndrome 5 +2 more	GUncertain significance
Select item 8931	NM_000179.3(MSH6):c.2633T>C (p.Val878Ala)	MSH6 (V878A +2 more)	Single nucleotide variant (missense variant)	Lynch syndrome	GBenign
Select item 138259	NM_000179.3(MSH6):c.2724A>G (p.Glu908=)	MSH6	Single nucleotide variant (synonymous variant)	not provided +5 more	GBenign/Likely benign
Select item 231129	NM_000179.3(MSH6):c.2850C>T (p.Ser950=)	MSH6	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +3 more	GLikely benign
Select item 184311	NM_000179.3(MSH6):c.2904C>G (p.Val968=)	MSH6	Single nucleotide variant (synonymous variant)	Breast and/or ovarian cancer +6 more	GBenign/Likely benign
Select item 89322	NM_000179.3(MSH6):c.2927G>A (p.Arg976His)	MSH6 (R976H +2 more)	Single nucleotide variant (missense variant)	Endometrial carcinoma +5 more	GConflicting classifications of pathogenicity
Select item 183936	NM_000179.3(MSH6):c.2982C>T (p.Tyr994=)	MSH6	Single nucleotide variant (synonymous variant)	Hereditary nonpolyposis colorectal neoplasms +5 more	GBenign/Likely benign
Select item 135838	NM_000179.3(MSH6):c.3024C>T (p.Thr1008=)	MSH6	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +6 more	GBenign/Likely benign
Select item 142781	NM_000179.3(MSH6):c.3037_3041del (p.Lys1013fs)	MSH6 (K711fs +1 more)	Deletion (frameshift variant)	Endometrial carcinoma +6 more	GPathogenic
Select item 42470	NM_000179.3(MSH6):c.3246G>T (p.Pro1082=)	MSH6	Single nucleotide variant (synonymous variant)	Lynch syndrome 1	GBenign
Select item 185357	NM_000179.3(MSH6):c.3265T>C (p.Leu1089=)	MSH6	Single nucleotide variant (synonymous variant)	Hereditary nonpolyposis colorectal neoplasms +5 more	GBenign/Likely benign
Select item 36589	NM_000179.3(MSH6):c.3306T>A (p.Thr1102=)	MSH6	Single nucleotide variant (synonymous variant)	Lynch syndrome	GBenign
Select item 220901	NM_000179.3(MSH6):c.3354G>A (p.Glu1118=)	MSH6	Single nucleotide variant (synonymous variant)	Lynch syndrome 5 +5 more	GConflicting classifications of pathogenicity
Select item 237189	NM_000179.3(MSH6):c.3426G>A (p.Thr1142=)	MSH6	Single nucleotide variant (synonymous variant)	Hereditary nonpolyposis colorectal neoplasms +5 more	GBenign/Likely benign
Select item 42471	NM_000179.3(MSH6):c.3438+14A>T	MSH6	Single nucleotide variant (intron variant)	Lynch syndrome	GBenign
Select item 89389	NM_000179.3(MSH6):c.3439-16C>T	MSH6	Single nucleotide variant (intron variant)	Lynch syndrome	GBenign
Select item 89400	NM_000179.3(MSH6):c.3488A>T (p.Glu1163Val)	MSH6 (E1163V +2 more)	Single nucleotide variant (missense variant)	Lynch syndrome	GLikely benign
Select item 1332178	NM_000179.3(MSH6):c.3491T>C (p.Val1164Ala)	MSH6 (V1034A +2 more)	Single nucleotide variant (missense variant)	Lynch syndrome 5 +1 more	GUncertain significance
Select item 89416	NM_000179.3(MSH6):c.3557-40T>A	MSH6	Single nucleotide variant (intron variant)	Lynch syndrome 1	GLikely benign
Select item 89432	NM_000179.3(MSH6):c.3646+91T>C	MSH6	Single nucleotide variant (intron variant)	Lynch syndrome	GBenign
Select item 36594	NM_000179.3(MSH6):c.3802-40C>G	MSH6	Single nucleotide variant (intron variant)	Lynch syndrome	GBenign
Select item 218078	NM_000179.3(MSH6):c.4002-25T>C	MSH6	Single nucleotide variant (intron variant)	Lynch syndrome 5	GLikely benign
Select item 378172	NM_000179.3(MSH6):c.4002-20T>G	MSH6	Single nucleotide variant (intron variant)	Hereditary cancer-predisposing syndrome +2 more	GLikely benign
Select item 234447	NM_000179.3(MSH6):c.4002-8A>T	MSH6	Single nucleotide variant (intron variant)	not specified +3 more	GBenign/Likely benign
Select item 89518	NM_000179.3(MSH6):c.4068_4071dup (p.Lys1358delinsAspTer)	MSH6	Duplication (nonsense)	Lynch syndrome	GLikely benign

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Items: 55