C2675481[trait identifier] AND "Labcorp Genetics (formerly Invitae), L - ClinVar - NCBI

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	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 2853073	NM_002691.4(POLD1):c.-1-25_16del	POLD1	Deletion (splice acceptor variant +1 more)	Colorectal cancer, susceptibility to, 10	GUncertain significance
Select item 647458	NC_000019.10:g.(?_50398842)_(50399494_?)del	POLD1	Deletion	Colorectal cancer, susceptibility to, 10	GUncertain significance
Select item 583694	NC_000019.9:g.(?_50902099)_(50906864_?)dup	POLD1	Duplication	Colorectal cancer, susceptibility to, 10	GUncertain significance
Select item 583662	NC_000019.9:g.(?_50902099)_(50921214_?)dup	LOC130064985, LOC130064986 +1 more	Duplication	Colorectal cancer, susceptibility to, 10	GUncertain significance
Select item 583863	NC_000019.10:g.(?_50398846)_(50403603_?)del	POLD1	Deletion	Colorectal cancer, susceptibility to, 10	GUncertain significance
Select item 537179	NC_000019.10:g.(?_50398846)_(50406523_?)del	POLD1	Deletion	Colorectal cancer, susceptibility to, 10	GUncertain significance
Select item 469167	NC_000019.10:g.(?_50398846)_(50399490_?)del	POLD1	Deletion	Colorectal cancer, susceptibility to, 10	GUncertain significance
Select item 417420	NC_000019.9:g.(?_50902108)_(50902741_?)dup	POLD1	Duplication	Colorectal cancer, susceptibility to, 10	GUncertain significance
Select item 1469315	NM_002691.4(POLD1):c.1A>C (p.Met1Leu)	POLD1 (M1L)	Single nucleotide variant (missense variant +2 more)	Colorectal cancer, susceptibility to, 10	GUncertain significance
Select item 845531	NM_002691.4(POLD1):c.1A>G (p.Met1Val)	POLD1 (M1V)	Single nucleotide variant (missense variant +2 more)	Colorectal cancer, susceptibility to, 10	GUncertain significance
Select item 822534	NM_002691.4(POLD1):c.2T>C (p.Met1Thr)	POLD1 (M1T)	Single nucleotide variant (missense variant +2 more)	POLD1-related disorder +3 more	GUncertain significance
Select item 371955	NM_002691.4(POLD1):c.2T>A (p.Met1Lys)	POLD1 (M1K)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 2016643	NM_002691.4(POLD1):c.4G>T (p.Asp2Tyr)	POLD1 (D2Y)	Single nucleotide variant (missense variant +1 more)	Colorectal cancer, susceptibility to, 10	GUncertain significance
Select item 1039963	NM_002691.4(POLD1):c.4G>C (p.Asp2His)	POLD1 (D2H)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 863206	NM_002691.4(POLD1):c.8G>A (p.Gly3Asp)	POLD1 (G3D)	Single nucleotide variant (missense variant +1 more)	Colorectal cancer, susceptibility to, 10	GUncertain significance
Select item 408029	NM_002691.4(POLD1):c.9C>T (p.Gly3=)	POLD1	Single nucleotide variant (synonymous variant +1 more)	Colorectal cancer, susceptibility to, 10 +1 more	GLikely benign
Select item 2848943	NM_002691.4(POLD1):c.10A>G (p.Lys4Glu)	POLD1 (K4E)	Single nucleotide variant (missense variant +1 more)	Colorectal cancer, susceptibility to, 10	GUncertain significance
Select item 848509	NM_002691.4(POLD1):c.10A>C (p.Lys4Gln)	POLD1 (K4Q)	Single nucleotide variant (missense variant +1 more)	Colorectal cancer, susceptibility to, 10	GUncertain significance
Select item 1478506	NM_002691.4(POLD1):c.11A>C (p.Lys4Thr)	POLD1 (K4T)	Single nucleotide variant (missense variant +1 more)	Colorectal cancer, susceptibility to, 10	GUncertain significance
Select item 1492196	NM_002691.4(POLD1):c.14GGC[1] (p.Arg6del)	POLD1 (R6del)	Microsatellite (inframe_deletion +1 more)	Colorectal cancer, susceptibility to, 10	GUncertain significance
Select item 239235	NM_002691.4(POLD1):c.13C>T (p.Arg5Trp)	POLD1 (R5W)	Single nucleotide variant (missense variant +1 more)	not provided +3 more	GConflicting classifications of pathogenicity
Select item 408051	NM_002691.4(POLD1):c.14G>A (p.Arg5Gln)	POLD1 (R5Q)	Single nucleotide variant (missense variant +1 more)	Immunodeficiency 120 +4 more	GConflicting classifications of pathogenicity
Select item 389551	NM_002691.4(POLD1):c.15G>T (p.Arg5=)	POLD1	Single nucleotide variant (synonymous variant +1 more)	Colorectal cancer, susceptibility to, 10 +1 more	GLikely benign
Select item 537104	NM_002691.4(POLD1):c.16C>T (p.Arg6Trp)	POLD1 (R6W)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +3 more	GConflicting classifications of pathogenicity
Select item 239256	NM_002691.4(POLD1):c.17G>C (p.Arg6Pro)	POLD1 (R6P)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +3 more	GConflicting classifications of pathogenicity
Select item 226047	NM_002691.4(POLD1):c.17G>A (p.Arg6Gln)	POLD1 (R6Q)	Single nucleotide variant (missense variant +1 more)	not specified +4 more	GConflicting classifications of pathogenicity
Select item 841189	NM_002691.4(POLD1):c.20C>A (p.Pro7Gln)	POLD1 (P7Q)	Single nucleotide variant (missense variant +1 more)	Colorectal cancer, susceptibility to, 10	GUncertain significance
Select item 756889	NM_002691.4(POLD1):c.21A>G (p.Pro7=)	POLD1	Single nucleotide variant (synonymous variant +1 more)	Colorectal cancer, susceptibility to, 10	GLikely benign
Select item 2817586	NM_002691.4(POLD1):c.22G>A (p.Gly8Ser)	POLD1 (G8S)	Single nucleotide variant (missense variant +1 more)	Colorectal cancer, susceptibility to, 10	GUncertain significance
Select item 2197943	NM_002691.4(POLD1):c.23G>C (p.Gly8Ala)	POLD1 (G8A)	Single nucleotide variant (missense variant +1 more)	Colorectal cancer, susceptibility to, 10	GUncertain significance
Select item 1903260	NM_002691.4(POLD1):c.23G>A (p.Gly8Asp)	POLD1 (G8D)	Single nucleotide variant (missense variant +1 more)	Colorectal cancer, susceptibility to, 10	GUncertain significance
Select item 387186	NM_002691.4(POLD1):c.24C>T (p.Gly8=)	POLD1	Single nucleotide variant (synonymous variant +1 more)	Colorectal cancer, susceptibility to, 10 +2 more	GLikely benign
Select item 2902906	NM_002691.4(POLD1):c.27_32del (p.7PG[2])	POLD1	Deletion (inframe_deletion +1 more)	Colorectal cancer, susceptibility to, 10	GUncertain significance
Select item 2830395	NM_002691.4(POLD1):c.25C>T (p.Pro9Ser)	POLD1 (P9S)	Single nucleotide variant (missense variant +1 more)	Colorectal cancer, susceptibility to, 10	GUncertain significance
Select item 537098	NM_002691.4(POLD1):c.26C>T (p.Pro9Leu)	POLD1 (P9L)	Single nucleotide variant (missense variant +1 more)	Colorectal cancer, susceptibility to, 10	GUncertain significance
Select item 484367	NM_002691.4(POLD1):c.27A>G (p.Pro9=)	POLD1	Single nucleotide variant (synonymous variant +1 more)	Colorectal cancer, susceptibility to, 10 +1 more	GLikely benign
Select item 972395	NM_002691.4(POLD1):c.28G>A (p.Gly10Arg)	POLD1 (G10R)	Single nucleotide variant (missense variant +1 more)	Colorectal cancer, susceptibility to, 10	GUncertain significance
Select item 2059467	NM_002691.4(POLD1):c.29G>T (p.Gly10Val)	POLD1 (G10V)	Single nucleotide variant (missense variant +1 more)	Colorectal cancer, susceptibility to, 10 +1 more	GUncertain significance OUncertain significance
Select item 1450338	NM_002691.4(POLD1):c.31C>T (p.Pro11Ser)	POLD1 (P11S)	Single nucleotide variant (missense variant +1 more)	Colorectal cancer, susceptibility to, 10	GUncertain significance
Select item 239344	NM_002691.4(POLD1):c.33C>T (p.Pro11=)	POLD1	Single nucleotide variant (synonymous variant +1 more)	Colorectal cancer, susceptibility to, 10 +3 more	GBenign
Select item 407998	NM_002691.4(POLD1):c.34G>A (p.Gly12Arg)	POLD1 (G12R)	Single nucleotide variant (missense variant +1 more)	not specified +5 more	GConflicting classifications of pathogenicity
Select item 2870624	NM_002691.4(POLD1):c.35G>A (p.Gly12Glu)	POLD1 (G12E)	Single nucleotide variant (missense variant +1 more)	Colorectal cancer, susceptibility to, 10	GUncertain significance
Select item 3000332	NM_002691.4(POLD1):c.36G>T (p.Gly12=)	POLD1	Single nucleotide variant (synonymous variant +1 more)	Colorectal cancer, susceptibility to, 10	GLikely benign
Select item 1605958	NM_002691.4(POLD1):c.36G>C (p.Gly12=)	POLD1	Single nucleotide variant (synonymous variant +1 more)	Colorectal cancer, susceptibility to, 10 +1 more	GLikely benign
Select item 761379	NM_002691.4(POLD1):c.36G>A (p.Gly12=)	POLD1	Single nucleotide variant (synonymous variant +1 more)	Colorectal cancer, susceptibility to, 10 +2 more	GConflicting classifications of pathogenicity
Select item 1051972	NM_002691.4(POLD1):c.37G>C (p.Val13Leu)	POLD1 (V13L)	Single nucleotide variant (missense variant +1 more)	Colorectal cancer, susceptibility to, 10	GUncertain significance
Select item 407974	NM_002691.4(POLD1):c.37G>T (p.Val13Leu)	POLD1 (V13L)	Single nucleotide variant (missense variant +1 more)	Colorectal cancer, susceptibility to, 10 +1 more	GUncertain significance
Select item 407967	NM_002691.4(POLD1):c.37G>A (p.Val13Met)	POLD1 (V13M)	Single nucleotide variant (missense variant +1 more)	Colorectal cancer, susceptibility to, 10 +1 more	GUncertain significance
Select item 2131923	NM_002691.4(POLD1):c.39G>T (p.Val13=)	POLD1	Single nucleotide variant (synonymous variant +1 more)	Colorectal cancer, susceptibility to, 10	GLikely benign
Select item 1055019	NM_002691.4(POLD1):c.40C>T (p.Pro14Ser)	POLD1 (P14S)	Single nucleotide variant (missense variant +1 more)	Colorectal cancer, susceptibility to, 10 +2 more	GUncertain significance
Select item 1362448	NM_002691.4(POLD1):c.41C>A (p.Pro14His)	POLD1 (P14H)	Single nucleotide variant (missense variant +1 more)	Colorectal cancer, susceptibility to, 10	GUncertain significance
Select item 2731060	NM_002691.4(POLD1):c.43C>T (p.Pro15Ser)	POLD1 (P15S)	Single nucleotide variant (missense variant +1 more)	Colorectal cancer, susceptibility to, 10	GUncertain significance
Select item 847274	NM_002691.4(POLD1):c.43_44insTTG (p.Pro15delinsLeuAla)	POLD1	Insertion (inframe_indel +1 more)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 657069	NM_002691.4(POLD1):c.44C>T (p.Pro15Leu)	POLD1 (P15L)	Single nucleotide variant (missense variant +1 more)	Colorectal cancer, susceptibility to, 10	GUncertain significance
Select item 469354	NM_002691.4(POLD1):c.45A>G (p.Pro15=)	POLD1	Single nucleotide variant (synonymous variant +1 more)	Colorectal cancer, susceptibility to, 10 +1 more	GLikely benign
Select item 496661	NM_002691.4(POLD1):c.46A>G (p.Lys16Glu)	POLD1 (K16E)	Single nucleotide variant (missense variant +1 more)	not provided +4 more	GConflicting classifications of pathogenicity
Select item 1647214	NM_002691.4(POLD1):c.49C>A (p.Arg17=)	POLD1	Single nucleotide variant (synonymous variant +1 more)	Colorectal cancer, susceptibility to, 10	GLikely benign
Select item 408109	NM_002691.4(POLD1):c.49C>T (p.Arg17Trp)	POLD1 (R17W)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +2 more	GConflicting classifications of pathogenicity
Select item 537111	NM_002691.4(POLD1):c.50G>T (p.Arg17Leu)	POLD1 (R17L)	Single nucleotide variant (missense variant +1 more)	Colorectal cancer, susceptibility to, 10 +1 more	GUncertain significance
Select item 486074	NM_002691.4(POLD1):c.53_61del (p.Ala18_Gly20del)	POLD1	Deletion (inframe_deletion +1 more)	Colorectal cancer, susceptibility to, 10 +1 more	GUncertain significance
Select item 408008	NM_002691.4(POLD1):c.50G>A (p.Arg17Gln)	POLD1 (R17Q)	Single nucleotide variant (missense variant +1 more)	Colorectal cancer, susceptibility to, 10 +2 more	GUncertain significance
Select item 1746028	NM_002691.4(POLD1):c.51G>C (p.Arg17=)	POLD1	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome +1 more	GLikely benign
Select item 1162130	NM_002691.4(POLD1):c.51G>A (p.Arg17=)	POLD1	Single nucleotide variant (synonymous variant +1 more)	Colorectal cancer, susceptibility to, 10	GLikely benign
Select item 578732	NM_002691.4(POLD1):c.52G>A (p.Ala18Thr)	POLD1 (A18T)	Single nucleotide variant (missense variant +1 more)	Colorectal cancer, susceptibility to, 10	GUncertain significance
Select item 414765	NM_002691.4(POLD1):c.55C>T (p.Arg19Cys)	POLD1 (R19C)	Single nucleotide variant (missense variant +1 more)	Colorectal cancer, susceptibility to, 10 +3 more	GConflicting classifications of pathogenicity
Select item 841540	NM_002691.4(POLD1):c.56G>T (p.Arg19Leu)	POLD1 (R19L)	Single nucleotide variant (missense variant +1 more)	Colorectal cancer, susceptibility to, 10	GUncertain significance
Select item 221055	NM_002691.4(POLD1):c.56G>A (p.Arg19His)	POLD1 (R19H)	Single nucleotide variant (missense variant +1 more)	not specified +4 more	GBenign/Likely benign
Select item 1749771	NM_002691.4(POLD1):c.57T>G (p.Arg19=)	POLD1	Single nucleotide variant (synonymous variant +1 more)	Colorectal cancer, susceptibility to, 10 +1 more	GLikely benign
Select item 1650944	NM_002691.4(POLD1):c.57T>C (p.Arg19=)	POLD1	Single nucleotide variant (synonymous variant +1 more)	Colorectal cancer, susceptibility to, 10	GLikely benign
Select item 646927	NM_002691.4(POLD1):c.58G>A (p.Gly20Arg)	POLD1 (G20R)	Single nucleotide variant (missense variant +1 more)	Colorectal cancer, susceptibility to, 10	GUncertain significance
Select item 2129649	NM_002691.4(POLD1):c.59G>T (p.Gly20Val)	POLD1 (G20V)	Single nucleotide variant (missense variant +1 more)	Colorectal cancer, susceptibility to, 10	GUncertain significance
Select item 654641	NM_002691.4(POLD1):c.59G>C (p.Gly20Ala)	POLD1 (G20A)	Single nucleotide variant (missense variant +1 more)	Colorectal cancer, susceptibility to, 10 +2 more	GUncertain significance
Select item 408031	NM_002691.4(POLD1):c.59G>A (p.Gly20Glu)	POLD1 (G20E)	Single nucleotide variant (missense variant +1 more)	not provided +2 more	GUncertain significance
Select item 1514276	NM_002691.4(POLD1):c.61G>C (p.Gly21Arg)	POLD1 (G21R)	Single nucleotide variant (missense variant +1 more)	Colorectal cancer, susceptibility to, 10	GUncertain significance
Select item 469371	NM_002691.4(POLD1):c.61G>T (p.Gly21Cys)	POLD1 (G21C)	Single nucleotide variant (missense variant +1 more)	Colorectal cancer, susceptibility to, 10	GUncertain significance
Select item 1018486	NM_002691.4(POLD1):c.62G>A (p.Gly21Asp)	POLD1 (G21D)	Single nucleotide variant (missense variant +1 more)	Colorectal cancer, susceptibility to, 10 +1 more	GUncertain significance
Select item 537097	NM_002691.4(POLD1):c.62G>T (p.Gly21Val)	POLD1 (G21V)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 469374	NM_002691.4(POLD1):c.64C>T (p.Leu22Phe)	POLD1 (L22F)	Single nucleotide variant (missense variant +1 more)	not provided +1 more	GUncertain significance
Select item 1131056	NM_002691.4(POLD1):c.66C>G (p.Leu22=)	POLD1	Single nucleotide variant (synonymous variant +1 more)	Colorectal cancer, susceptibility to, 10	GLikely benign
Select item 469377	NM_002691.4(POLD1):c.66C>T (p.Leu22=)	POLD1	Single nucleotide variant (synonymous variant +1 more)	Colorectal cancer, susceptibility to, 10 +1 more	GLikely benign
Select item 952034	NM_002691.4(POLD1):c.67T>C (p.Trp23Arg)	POLD1 (W23R)	Single nucleotide variant (missense variant +1 more)	Colorectal cancer, susceptibility to, 10 +1 more	GUncertain significance
Select item 1481498	NM_002691.4(POLD1):c.69G>T (p.Trp23Cys)	POLD1 (W23C)	Single nucleotide variant (missense variant +1 more)	Colorectal cancer, susceptibility to, 10 +1 more	GUncertain significance
Select item 1012122	NM_002691.4(POLD1):c.69G>A (p.Trp23Ter)	POLD1 (W23*)	Single nucleotide variant (nonsense +1 more)	Colorectal cancer, susceptibility to, 10	GUncertain significance
Select item 537054	NM_002691.4(POLD1):c.71ATG[5] (p.Asp27dup)	POLD1	Microsatellite (inframe_insertion +1 more)	Colorectal cancer, susceptibility to, 10 +1 more	GUncertain significance
Select item 1417288	NM_002691.4(POLD1):c.70G>A (p.Asp24Asn)	POLD1 (D24N)	Single nucleotide variant (missense variant +1 more)	Colorectal cancer, susceptibility to, 10	GUncertain significance
Select item 827385	NM_002691.4(POLD1):c.71ATG[3] (p.Asp27del)	POLD1 (D27del)	Microsatellite (inframe_deletion +1 more)	Colorectal cancer, susceptibility to, 10 +1 more	GUncertain significance
Select item 565940	NM_002691.4(POLD1):c.73G>A (p.Asp25Asn)	POLD1 (D25N)	Single nucleotide variant (missense variant +1 more)	Colorectal cancer, susceptibility to, 10	GUncertain significance
Select item 1525503	NM_002691.4(POLD1):c.74A>T (p.Asp25Val)	POLD1 (D25V)	Single nucleotide variant (missense variant +1 more)	Colorectal cancer, susceptibility to, 10	GUncertain significance
Select item 1061519	NM_002691.4(POLD1):c.74A>G (p.Asp25Gly)	POLD1 (D25G)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 513674	NM_002691.4(POLD1):c.75T>C (p.Asp25=)	POLD1	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome +2 more	GLikely benign
Select item 469384	NM_002691.4(POLD1):c.75del (p.Asp25fs)	POLD1 (D25fs)	Deletion (frameshift variant +1 more)	Colorectal cancer, susceptibility to, 10	GUncertain significance
Select item 537056	NM_002691.4(POLD1):c.77A>G (p.Asp26Gly)	POLD1 (D26G)	Single nucleotide variant (missense variant +1 more)	Colorectal cancer, susceptibility to, 10 +2 more	GUncertain significance
Select item 1305724	NM_002691.4(POLD1):c.80A>G (p.Asp27Gly)	POLD1 (D27G)	Single nucleotide variant (missense variant +1 more)	not provided +1 more	GUncertain significance
Select item 245862	NM_002691.4(POLD1):c.80A>T (p.Asp27Val)	POLD1 (D27V)	Single nucleotide variant (missense variant +1 more)	not provided +3 more	GConflicting classifications of pathogenicity
Select item 1497309	NM_002691.4(POLD1):c.83C>G (p.Ala28Gly)	POLD1 (A28G)	Single nucleotide variant (missense variant +1 more)	Colorectal cancer, susceptibility to, 10	GUncertain significance
Select item 469390	NM_002691.4(POLD1):c.83C>T (p.Ala28Val)	POLD1 (A28V)	Single nucleotide variant (missense variant +1 more)	not provided +2 more	GUncertain significance
Select item 744174	NM_002691.4(POLD1):c.84A>C (p.Ala28=)	POLD1	Single nucleotide variant (synonymous variant +1 more)	Colorectal cancer, susceptibility to, 10 +1 more	GLikely benign
Select item 560824	NM_002691.4(POLD1):c.84A>G (p.Ala28=)	POLD1	Single nucleotide variant (synonymous variant +1 more)	not provided +2 more	GLikely benign
Select item 407976	NM_002691.4(POLD1):c.85C>T (p.Pro29Ser)	POLD1 (P29S)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 221163	NM_002691.4(POLD1):c.88C>T (p.Arg30Trp)	POLD1 (R30W)	Single nucleotide variant (missense variant +1 more)	Colorectal cancer, susceptibility to, 10 +4 more	GBenign/Likely benign

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