ClinVar

Yersinia Pestis Resistance

Osei-Owusu et al. (2019) identified FPR1 R190W as a candidate resistance allele in humans that protects neutrophils from destruction by the Yersinia pestis type III secretion system (T3SS), which targets immune cells for destruction. In a human donor whose neutrophils exhibited decreased T3SS translocation and reduced chemotaxis toward N-formylpeptide and Y. pestis, Osei-Owusu et al. (2019) identified a SNP in the FPR1 gene, rs5030880A-T, that designated an arg190-to-trp (R190W) substitution in extracellular loop 2 between transmembrane domains 4 and 5. The authors stated that this variant occurs in 11 to 13% of Europeans and Americans of European descent, 6 to 9% of Africans and Americans of African descent, and 20% of Asians. This donor did not carry the CCR5-delta-32 allele (601373.0001). Osei-Owusu et al. (2019) generated macrophages expressing FPR1 R190W and found that they exhibited reduced effector translocation during Y. pestis infection, and chemotoaxis experiments revealed reduced migration of R190W-expressing monocytes towards N-formylpeptide and Y. pestis compared to controls.