U.S. flag

An official website of the United States government

Format
Items per page
Sort by

Send to:

Choose Destination

Search results

Items: 1 to 20 of 22

1.

Clinical and pathological findings in neurolymphomatosis: preliminary association with gene expression profiles in sural nerves.

(Submitter supplied) Although inflammation appears to play a role in neurolymphomatosis (NL), the mechanisms leading to degeneration in the peripheral nervous system are poorly understood. The purpose of this exploratory study was to identify molecular pathways underlying NL pathogenesis, combining clinical and neuropathological investigation with gene expression (GE) studies. Based on the neuropathic symptoms and signs, NL patients were classified into three forms of neuropathy: chronic symmetrical sensorimotor polyneuropathy (SMPN, n=3), multiple mononeuropathy (MN, n=4) and acute motor-sensory axonal neuropathy (AMSAN, n=1). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13369
16 Samples
Download data: TXT
Series
Accession:
GSE213455
ID:
200213455
2.

Transcriptome analysis of collagen VI-related muscular dystrophy muscle biopsies

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Expression profiling by array
Platforms:
GPL13369 GPL11154
72 Samples
Download data: IDAT
Series
Accession:
GSE103975
ID:
200103975
3.

Transcriptome analysis of collagen VI-related muscular dystrophy muscle biopsies [Microarray].

(Submitter supplied) Collagen VI-related muscular dystrophies (COL6RD) are a rare, inherited group of congenital muscular dystrophies. The phenotype spans from an early-onset, severe, and rapidly progressive clinical course in Ullrich congenital muscular dystrophy (UCMD), to a late-onset, mild and slowly progressive form in Bethlem muscular dystrophy (BM). COL6RD are caused by pathogenic variants in any of the three collagen type VI genes (COL6A1, COL6A2, COL6A3), which cause absence, reduction, mislocalization, or dysfunction of the collagen VI microfibrils in the skeletal muscle extracellular matrix (myomatrix), leading to yet incompletely understood downstream effects. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13369
36 Samples
Download data: IDAT
Series
Accession:
GSE103972
ID:
200103972
4.

Characterisation of gene expression of cancer-associated and normal fibroblasts from lobular and ductal breast cancer patients

(Submitter supplied) The purpose of this study was to characterise gene expression differences between cultured human cancer-associated fibroblasts and normal fibroblasts from lobular and ductal breast cancer patients.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13369
12 Samples
Download data: TXT
Series
Accession:
GSE148156
ID:
200148156
5.

Myeloid cells are enriched in tonsillar crypts providing insight into the host tropism of HPV

(Submitter supplied) Viruses are the second leading cause of cancer worldwide, and human papillomavirus (HPV)-associated head and neck cancers are increasing in incidence in the United States. HPV preferentially infects the crypts of the tonsils rather than the surface epithelium. The present study sought to characterize the unique microenvironment within the crypts to better understand the host tropism of HPV to a lymphoid rich organ. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13369
12 Samples
Download data: TXT
Series
Accession:
GSE155139
ID:
200155139
6.

Plant-derived soybean peroxidase stimulates osteoblast collagen biosynthesis and matrix mineralization

(Submitter supplied) Bone defects arising from fractures or disease represent a significant problem for surgeons to manage and are a substantial economic burden on the healthcare economy. Recent advances in the development of biomaterial substitutes provides an attractive alternative to the current “gold standard” autologous bone grafting. Despite on-going research, we are yet to identify cost effective biocompatible, osteo-inductive factors that stimulate controlled, accelerated bone regeneration.We have recently reported that enzymes with peroxidase activity possess previously unrecognised roles in extracellular matrix biosynthesis, angiogenesis and osteoclastogenesis, which are essential processes in bone remodelling and repair. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13369
6 Samples
Download data: TXT, XLSX
Series
Accession:
GSE168303
ID:
200168303
7.

Secondhand smoke alters arachidonic acid metabolism in infants and children with cystic fibrosis

(Submitter supplied) Children ages 0-10 years old with CF were recruited from 2012-2015 at the outpatient CF clinic, and classified according to age (infants <1 year old, vs. children 1-10 years old). The diagnosis of CF was defined as two disease-causing mutations or a sweat chloride test ≥ 60 mmol/L. Hair and blood samples were collected from each subject. Hair nicotine concentrations were determined and considered as the primary objective measure of SHSe. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13369
40 Samples
Download data: TXT
Series
Accession:
GSE107846
ID:
200107846
8.

Associations between IFI44L gene variants and rates of respiratory tract infections during early childhood

(Submitter supplied) Background: Genetic heterogeneity in the innate immune system may account for variable susceptibility to respiratory tract infections (RTIs) in children. Objective: We aimed to assess the impact of polymorphisms rs273259 and rs1333969 in type I interferon related gene IFI44L on susceptibility to RTIs and acute otitis media in children. Methods: In two prospective, population-based birth cohorts, the FinnBrain Birth Cohort Study and the STEPS Study, IFI44L genotypes for rs273259 and rs1333969 were determined in relation to the development of RTIs until one and two years of age, respectively, and adjusted incidence rate ratios (aIRR) or odds ratios (OR) were calculated. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13369
71 Samples
Download data: TXT
Series
Accession:
GSE150133
ID:
200150133
9.

Functional rare and low frequency variants in BLK and BANK contribute to human lupus pathogenesis

(Submitter supplied) Systemic lupus erythematosus (SLE) is the prototypic systemic autoimmune disease. It is thought that many common variant gene loci of weak effect act additively to predispose to common autoimmune diseases, while the contribution of rare variants remains unclear. Here we describe that rare coding variants in lupus-risk genes are present in most SLE patients and healthy controls. We demonstrate the functional consequences of rare and low frequency missense variants in the interacting proteins BLK and BANK, which are present alone, or in combination, in a substantial proportion of lupus patients. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13369
40 Samples
Download data: TXT
Series
Accession:
GSE126307
ID:
200126307
10.

Dynamic imbalance between cancer cell subpopulations induced by Transforming Growth Factor Beta (TGF-β) is associated with a DNA methylome switch

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array; Methylation profiling by genome tiling array
Platforms:
GPL13369 GPL13534
36 Samples
Download data: IDAT
Series
Accession:
GSE127829
ID:
200127829
11.

Dynamic imbalance between cancer cell subpopulations induced by Transforming Growth Factor Beta (TGF-β) is associated with a DNA methylome switch [expression array]

(Submitter supplied) Distinct subpopulations of neoplastic cells within tumors, including hepatocellular carcinoma (HCC), display pronounced ability to initiate new tumors and induce metastasis. Recent evidence suggests that signals from transforming growth factor beta (TGF-β) may increase the survival of these so called tumor initiating cells leading to poor HCC prognosis. However, how TGF-β establishes and modifies the key features of these cell subpopulations is not fully understood. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13369
12 Samples
Download data: IDAT
Series
Accession:
GSE127763
ID:
200127763
12.

Interleukin 10 and succinate synergize to provide B cell help in human lupus

(Submitter supplied) Autoantibodies against nucleic acids are a hallmark of Systemic Lupus Erythematosus. We recently uncovered that human oxidized DNA of mitochondrial origin released by activated lupus neutrophils represents a distinct class of interferogenic TLR9 ligand for plasmacytoid dendritic cells. We now show that oxidized mitochondrial DNA-activated plasmacytoid dendritic cells skew naïve CD4+ T cells towards IL2low, IFNγhigh, IL10high secreting B helper cells different from follicular helper and Type 1 regulatory CD4+ T cells. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13369
9 Samples
Download data: TXT
Series
Accession:
GSE93679
ID:
200093679
13.

Senescent carcinoma associated fibroblasts up-regulate interleukin 8 to enhance pancreatic cancer progression

(Submitter supplied) Comparison of the gene expression profile of senescent versus non-senescent cancer associated fibroblasts. The hypothesis tested is that senescent CAFs secrete higher levels of cytokines that promote cancer progression.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13369
9 Samples
Download data: TXT
Series
Accession:
GSE81368
ID:
200081368
14.

Gene expression analyses of SMAD4 knockdown in pancreatic cell line

(Submitter supplied) The transforming growth factor β (TGF-β) signaling protein SMAD4 is lost in 60% of PDAC, and this has been associated with poorer prognosis. We expressed SMAD4 in human PDAC cell lines BxPC3, by selection of stable clones containing an inducible SMAD4 Tet-ON construct. After 24h of SMAD4 expression, TGF-β signaling-dependent G1-arrest was observed in BxPC3 cells with an increase in the G1-phase fraction from 48.9% to 71.5%. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13369
12 Samples
Download data: TXT
Series
Accession:
GSE70940
ID:
200070940
15.

Gene profile of breast cancer tumors with low and high FAK expression

(Submitter supplied) The gene expression profiles were identified in breast cancer tumors with different level of FAK
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13369
12 Samples
Download data: TXT
Series
Accession:
GSE53618
ID:
200053618
16.

Gene profile of colon cancer cells treated with Y15 (FAK inhibitor) and 5-fluorouracil

(Submitter supplied) The gene expression profiles were identified in colon cancer cell lines treated either with Y15 or with 5-FU
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13369
12 Samples
Download data: TXT
Series
Accession:
GSE53617
ID:
200053617
17.

Gene-expression profiles of archived section of formalin-fixed paraffin-embedded (AS-FFPE) liver and tumor tissues from hepatocellular carcinoma patients (Illumina and Nanostring)

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL17230 GPL13369
160 Samples
Download data
Series
Accession:
GSE47595
ID:
200047595
18.

Gene-expression profiles of archived section of formalin-fixed paraffin-embedded (AS-FFPE) liver and tumor tissues from hepatocellular carcinoma patients

(Submitter supplied) Background and Aims Formalin-fixed, paraffin-embedded (FFPE) tissue is the most commonly available form of archived clinical specimens, which are often stored as thin sections on glass slides. RNA isolated from such archived section (AS) of FFPE tissue is more degraded compared to freshly cut (FC) FFPE section because of prolonged air exposure. In this study, we evaluated performance of transcriptome profiling-based disease classification in AS-FFPE tissue. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13369
136 Samples
Download data: TXT
Series
Accession:
GSE46444
ID:
200046444
19.

Genome-wide analysis of gene expression in response to bortezomib treatment

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL13369 GPL6887
50 Samples
Download data
Series
Accession:
GSE41930
ID:
200041930
20.

Genome-wide analysis of gene expression in response to bortezomib treatment [human cell lines].

(Submitter supplied) Genome-wide analysis of gene expression in response to bortezomib treatment (33 nM) in cell lines before and after selection for resistance. Multiple myeloma (MM) is a hematologic malignancy characterized by the proliferation of neoplastic plasma cells in the bone marrow. While the first-to-market proteasome inhibitor bortezomib/VELCADE has been successfully used to treat myeloma patients, drug resistance remains an emerging problem. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13369
6 Samples
Download data: TXT
Series
Accession:
GSE41929
ID:
200041929
Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

db=gds|term=GPL13369[RGSE]|query=1|qty=3|blobid=MCID_6758365779cb8359a2c7404b|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
   Taxonomic Groups  [List]
Tree placeholder
    Top Organisms  [Tree]

Find related data

Search details

See more...

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Support Center