GEO DataSets

(Submitter supplied) Berberin has been shown to inhibit 3T3L1 preadipocytes differentiation. This study aims to determine the genes regulated by berberine and clarify the possible molecular mechanism underlying the action.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL13692

4 Samples

Download data: GPR

(Submitter supplied) Berberin has been shown to inhibit HepG2 cell viability. This study aims to determine the genes regulated by berberine and clarify the possible molecular mechanism underlying the action.

Organism:

Homo sapiens; Mus musculus

Type:

Expression profiling by array

Platform:

GPL13692

4 Samples

Download data: GPR

(Submitter supplied) Berberine shows protective effect against AAPH-damaged C17.2 neural stem cells. This study aims to determine the genes regulated by berberine and clarify the possible molecular mechanism underlying the action.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL13692

4 Samples

Download data: GPR, XLSX

(Submitter supplied) In previous studies, microcurrent electrical nerve stimulation (MENS) has been also used for pain control and muscular growth, but no literatures study the effects and mechanisms of MENS for DM management. Here we analyzed the effect of MENS and MENS mechanisms using phenotype data and omics data of mouse animal model. The results showed MENS regulated diabetes-related pathways to lower blood glucose.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL13692

12 Samples

Download data: GPR

(Submitter supplied) Sheng-Hua-Tang (SHT) is commonly used to treat female illnesses, especially postpartum conditioning. However, its effects and mechanisms on female reproductive system remain unclear. The aim of the present study was to investigate the effect of SHT on female brain-ovary-uterus axis from bench to clinic.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL13692

6 Samples

Download data: GPR

(Submitter supplied) Vanillin is a natural dietary flavoring. Colorectal cancer (CRC) is one of the common malignancies in the world. Chronic intestinal inflammation is a risk factor for the development of CRC. We have previously found that vanillin improves and prevents the colitis in mice. Here, we evaluated the inhibitory activities of vanillin on a mouse model of colitis-induced colon cancer.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL13692

9 Samples

Download data: GPR

(Submitter supplied) Vanillin is one of the most widely used flavouring products worldwide. Psoriasis is a chronic inflammatory skin disorder. Here we analyzed the effect of vanillin on imiquimod (IMQ)-induced psoriatic skin inflammation in mice.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL13692

9 Samples

Download data: GPR

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:

GPL16331 GPL13692

16 Samples

Download data: BED, BEDGRAPH, GPR

(Submitter supplied) Cordycepin, a 3-deoxyadenosine, a traditional Chinese medicine. Studies have demonstrated that cordycepin could modulate multiple signaling pathways to induce cancer cell death. This study aims to determine the genes regulated by Cordycepin and clarify the possible molecular mechanism underlying their action.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL13692

4 Samples

Download data: GPR, XLSX

(Submitter supplied) Large intergenic non-coding RNAs (lincRNAs) play widespread roles in epigenetic regulation during multiple differentiation processes, but little is known about their mode of action in cardiac differentiation. Here, we identified the key roles of a lincRNA, termed linc1405, in modulating the core network of cardiac differentiation by functionally interacting with Eomes. Chromatin- and RNA- immunoprecipitation assays showed that exon2 of linc1405 physically mediates a complex consisting of Eomes, Trithorax group (TrxG) subunit WDR5, and histone acetyltransferase GCN5 binding at the enhancer region of Mesp1 gene and activates its expression during cardiac mesoderm specification of embryonic stem cells. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL13692

5 Samples

Download data: GPR

(Submitter supplied) Though there has been extensive investigation of the kidney's acute cellular and molecular responses following cisplatin treatment, the mechanisms of progression from acute to chronic disease have not been explored. In this study, we use functional and morphological metrics to establish a time point when the transition from acute repairable kidney injury to chronic irreparable disease is clearly established. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL13692

3 Samples

Download data: TXT

(Submitter supplied) In previous study, we demonstrated adenine-induced cell signaling on anti-inflammation in BV2 cells. To investigate the changes of transcriptome mediated by adenine, we used microarrays to compare the difference in expression levels.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL13692

6 Samples

Download data: GPR

(Submitter supplied) We performed gene expression profiling by microarray using RNA extracted from the tibialis anterior of control and Hira myofiber-specific conditional knockout mice at 6 weeks of age. Hira is a histone chaperone responsible for replication-independent incorporation of histone variant H3.3 at actively transcribed loci. Conditional knockout of Hira in myofibers caused hypertrophy, degeneration, and increased the percentage of type I fibers. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL13692

24 Samples

Download data: GPR

(Submitter supplied) We performed gene expression profiling by microarray using RNA extracted from the tibialis anterior of control and Hira myofiber-specific conditional knockout mice at 6 months of age. Hira is a histone chaperone responsible for replication-independent incorporation of histone variant H3.3 at actively transcribed loci. Conditional knockout of Hira in myofibers improved strength and endurance, caused hypertrophy and regeneration, and increased the percentage of type I fibers. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL13692

24 Samples

Download data: GPR

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platforms:

GPL15816 GPL13692

30 Samples

Download data

(Submitter supplied) Pathological cardiac hypertrophy, a dynamic remodeling process, is a major risk factor for heart failure. Although a number of key regulators and related genes have been identified, how the transcription factors (TFs) dynamically regulate the associated genes and control the morphological and electrophysiological changes during the hypertrophic process are still largely unknown. In this study, we obtained the time-course transcriptomes at five time points in four weeks from male murine hearts subjected to transverse aorta banding surgery. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL13692

10 Samples

Download data: TXT

(Submitter supplied) We performed gene expression profiling by microarray using RNA extracted from healthy free wall left ventricle tissues from control and Hira cardiomyocyte-specific conditional knockout mice at 6 weeks of age. Hira is a histone chaperone responsible for replication-independent incorporation of histone variant H3.3 at actively transcribed regions. Conditional knockout of Hira in cardiomyocytes resulted in impaired cardiac function, cardiomyocyte degeneration and focal replacement fibrosis. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL13692

24 Samples

Download data: GPR

(Submitter supplied) To examine the molecular alterations in cells with different sensitivity, genome-wide expression of the leukemic cells was profiled, revealing that overall 366 and 212 genes became upregulated or downregulated, respectively, in the resistant cells. Many of these genes are involved in the regulation of cell cycle, cellular proliferation, and apoptosis.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL13692

3 Samples

Download data: GPR

(Submitter supplied) In this study, we identified a number of genes whose expression are regulated by the Hippo tumor suppressor pathway. To disrupt Hippo signaling in the mouse heart, we inactivated the single mammalian Salv ortholog using a Salv conditional null allele and the Nkx2.5 cre allele that directs cardiac cre activity. Total RNA from P8-stage hearts were used for expression profiling.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL13692

12 Samples

Download data: GPR

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platforms:

GPL13692 GPL15216

28 Samples

Download data: TXT