GEO DataSets

(Submitter supplied) Successful production of offspring in mammals is determined by the growth and apoptosis pathway, which is responsible for maintaining the balance between the estrous cycle. It is also believed that the development of the porcine ovary is regulated similarly; however, the molecular mechanism underlying differences in follicle development in the minipig and pig has yet to be elucidated. The present study aimed to identify developmental-associated genes differentially expressed in the minipig vs. more...

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL16571

2 Samples

Download data: TXT

(Submitter supplied) After observing the surgical wounds on the 28th postoperative day, the experimental animals were put to death. Vascular tissues from the surgical site were taken and subjected to gene microarray analysis. This was used to examine the effect of TAG repair in the experimental group and Exoseal repair in the control group.

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL16571

6 Samples

Download data: TXT

(Submitter supplied) Gottingen minipigs mirror the physiological radiation response observed in humans and hence make an ideal candidate model for studying radiation biodosimetry for both limited-sized and mass casualty incidents. We examined the whole blood gene expression profiles at day 1, 3 and 7 after total-body irradiation with 1.7, 1.9, 2.1 and 2.3 Gy doses of gamma-rays. Blood taken one day prior to radiation served as control. more...

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL16571

96 Samples

Download data: TXT

(Submitter supplied) The present work identified gene expression changes in response to total body irradiation (TBI) in heart, lungs, and liver tissue in Gottingen minipigs. Animals were exposed to 1.7 Gy, 1.9 Gy, 2.1 Gy and 2.3 Gy of TBI and were followed for 45 days. Organ samples were collected at the end of 45 days or sooner if the animal displayed morbidity necessitating euthanasia. RNA was extracted and gene expression profiling studied using Agilent arrays.

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL16571

90 Samples

Download data: TXT, XLSX

(Submitter supplied) The knowledge regarding the reproductive-status-related changes occurring within the transcriptome of the porcine pituitary is limited. This study aimed to compare pituitary gland gene expression profiles of pigs during the maternal recognition of pregnancy period (days 12-13 of pregnancy) with pigs during the respective days of the estrous cycle using a microarray approach. Analysis indicated 482 differentially expressed genes (DEGs) with a FC ≥ 1.5 (p < 0.05) in the pituitary of pregnant vs. estrous-cyclic pigs. more...

Organism:

Sus scrofa domesticus; Sus scrofa

Type:

Expression profiling by array

Platform:

GPL16571

4 Samples

Download data: TXT

(Submitter supplied) Porcine endometrial transcriptome has been profiled using expression micrarrays to determine the effect of PGE2 administered together with E2 on global gene expression profile.

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL16571

19 Samples

Download data: TXT

(Submitter supplied) To explore the molecular mechanisms of meniscal degeneration after resection of anterior cruciate ligament and lateral collateral ligament, we have employed whole genome microarray expression profiling as a discovery platform to identify genes with the potential role in the development of meniscal degeneration. The anterior cruciate ligament (ACL) and lateral collateral ligament (LCL) of the right rear limbs of Wuzhishan minipig was resected at the same time, and the left rear limbs was sham operated. more...

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL16571

14 Samples

Download data: TXT

(Submitter supplied) Microarray analysis was done to compare the response of EBOV-infected pigs that were pre-treated with Ad5-porIFNα or PBS. At 3 days post EBOV infection, pigs that had been pre-treated with Ad5-porIFNα displayed upregulation of many genes related to the immune response in contrast to pigs treated with PBS. The largest category of induced genes included cytokines and chemokines that affect T-cell differentiation (IL27) and T-cell recruitment (CCL5, CCL23, CCL24, CXCL9, CXCL11)

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL16571

24 Samples

Download data: TXT, XLSX

(Submitter supplied) To further study of pcv2-related diseases, we have employed whole genome microarray expression profiling as a discovery platform to identify ileal differentially expressed genes of piglets after pcv2 infection. Infected and uninfected piglets were sampled and analyzed by whole genome microarray expression profiling. The result showed 43603 differencially expressed genes in ileum after PCV2 infection. more...

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL16571

12 Samples

Download data: TXT

(Submitter supplied) Although pigment synthesis is well understood, relevant mechanisms of psychologically debilitating dyspigmentation in nascent tissue after cutaneous injuries are still unknown. Here, differences in genomic transcription of hyper- and hypopigmented tissue relative to uninjured skin were investigated using a red Duroc swine scar model. Transcription profiles differed based on pigmentation phenotypes with a trend of more upregulation or downregulation in hyper- or hypopigmented scars, respectively. more...

Organism:

Sus scrofa domesticus; Sus scrofa

Type:

Expression profiling by array

Platform:

GPL16571

28 Samples

Download data: TXT

(Submitter supplied) Meniscus degeneration is one of the manifestations of knee osteoarthritis, but its specific molecular mechanism is still not very clear. We used Wuzhishan pig's anterior cruciate ligament resection to prepare meniscus degeneration models, and applied gene chip technology to detect the expression of differential genes in the degenerated meniscus tissue. The study detected a total of 893 differentially expressed genes, mainly related to hormones, apoptosis, inflammation and other mechanisms, and analyzed that TRP channels may play a key role. more...

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL16571

14 Samples

Download data: TXT

(Submitter supplied) In pigs, the peri-implantation period is recognized as determinant of successful reproduction, and it is controlled by neuroendocrinal interactions among signals originating from the female hypothalamic-pituitary-ovarian axis, uterus, and developing embryo. The transcriptomic activity of the pituitary gland may influence reproductive processes occurring in pigs during the peri-implantation period. The aim of this study was to determine alternations in gene expression in the porcine pituitary gland during the peri-implantation period (days 15-16 of pregnancy) in comparison with that during the respective days of the estrous cycle using a microarray approach.

Organism:

Sus scrofa; Sus scrofa domesticus

Type:

Expression profiling by array

Platform:

GPL16571

4 Samples

Download data: TXT

(Submitter supplied) Thermal condition is an important envrionment factor to produce healthy pig. A mineral heat ware, RAVI is a regenerative far-infrared heating system. The purpose of this sutyd was to evaluate immunostimulating effects in pigs when RAVI was applied to maintain thermal condition compared with gasoline heater.

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL16571

12 Samples

Download data: TXT, XLSX

(Submitter supplied) Adiponectin is secreted by the white adipose tissue and is one of the most important hormones that regulate metabolic homeostasis. The expression of adiponectin and adiponectin receptor genes and proteins in reproductive organs, such as the testes, ovaries and uterus, suggests that adiponectin is also involved in the regulation of reproductive functions. The aim of this study was to explore the influence of adiponectin on global gene expression in the porcine endometrium during early gestation, on days 15 to 16 of pregnancy (implantation period).

Organism:

Sus scrofa; Sus scrofa domesticus

Type:

Expression profiling by array

Platform:

GPL16571

4 Samples

Download data: TXT

(Submitter supplied) Orexins, namely orexin A (OXA) and orexin B (OXB) belongs to the family of neuropeptides produced mainly by specific neurons of the lateral region of the hypothalamus. Primarily orexins were recognized as hormones involved exclusively in the regulation of food intake and energy homeostasis. However, a growing body of evidences indicate their involvement in the regulation of an increasing number of biological processes, inter alia, in the regulation of the reproductive functions. more...

Organism:

Sus scrofa domesticus; Sus scrofa

Type:

Expression profiling by array

Platform:

GPL16571

4 Samples

Download data: TXT

(Submitter supplied) Orexin A (OXA) and orexin B (OXB) are hypothalamic-derived peptides that participate in the regulation of energy metabolism, food intake and reproductive function by influencing the hypothalamic-pituitary-ovarian axis. Orexins are also produced in the endometrium, myometrium and placenta, which suggests that they could act as a link between energy metabolism and the reproductive system. The aim of this study was to explore the influence of orexin B on global gene expression in the porcine myometrium during early gestation, on days 15 to 16 of pregnancy (implantation period).

Organism:

Sus scrofa domesticus; Sus scrofa

Type:

Expression profiling by array

Platform:

GPL16571

4 Samples

Download data: TXT

(Submitter supplied) Adiponectin is a hormone secreted primarily by white adipose tissue. Recent studies have shown that adiponectin and its receptors (AdipoR1 and AdipoR2) are expressed in different reproductive tissues, including the ovary and uterus. This newly discovered endocrine system plays an important role in the regulation of reproductive processes. The aim of this study was to explore the influence of adiponectin on global gene expression in the porcine endometrium during early gestation, on days 15 to 16 of pregnancy (implantation period).

Organism:

Sus scrofa; Sus scrofa domesticus

Type:

Expression profiling by array

Platform:

GPL16571

4 Samples

Download data: TXT

(Submitter supplied) Adiponectin is thought to be involved in the regulation of metabolic homeostasis and reproductive processes. Adiponectin controls carbohydrate and lipid metabolism by regulating the fatty acid oxidation process, increasing insulin sensitivity and decreasing plasma triglyceride levels. Adiponectin also plays an important role in the modulation of female reproductive functions, both directly and by influencing the secretory functions of the higher branches of the hypothalamic-pituitary-gonadal axis. more...

Organism:

Sus scrofa; Sus scrofa domesticus

Type:

Expression profiling by array

Platform:

GPL16571

4 Samples

Download data: TXT

(Submitter supplied) Orexins belong to the group of metabolism regulating factors connected mainly with the nervous system. Both biologically active neuropeptides, orexin A (OXA) and orexin B (OXB) are products of the proteolytic cleavage of common 130 amino-acid precursor – prepro-orexin (PPO). In the reproductive system orexins has been found to act not only on the endocrine, but also auto- and paracrine manner. In the present study we focused on the effect of OXA treatment on the global gene expression in the porcine myometrium during the most dynamic phase of the early pregnancy – the implantation period (days 15 to 16 of gestation).

Organism:

Sus scrofa; Sus scrofa domesticus

Type:

Expression profiling by array

Platform:

GPL16571

4 Samples

Download data: TXT

(Submitter supplied) Cytotoxic therapy leads to marked changes in intestinal structure, function, immunity and microbiota. Information about chemotherapy-induced intestinal gene expression may provide insights into the mechanisms underlying gut toxicity, and help to identify biomarkers and targets for intervention. We investigated jejunal tissue from piglets subjected to two different, clinically-relevant chemotherapy regimens, 1) busulfan plus cyclophosphamide (BUCY) and 2) doxorubicin (DOX). more...

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL16571

22 Samples

Download data: TXT