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Items: 10

1.

Molecular signature predictive of long-term liver fibrosis progression to inform anti-fibrotic drug development

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
5 related Platforms
917 Samples
Download data
Series
Accession:
GSE85550
ID:
200085550
2.

Prognostic Liver Signature profiles in biopsy tissues from chronic hepatitis C patients with HIV co-infection followed for fibrosis progression

(Submitter supplied) Background/Aims: There is a major unmet need to assess prognostic impact of anti-fibrotics in clinical trials due to the slow rate of liver fibrosis progression. We aimed to develop a surrogate biomarker to predict future fibrosis progression. Methods: A Fibrosis Progression Signature (FPS) was defined to predict fibrosis progression within 5 years in HCV and NAFLD patients with no to minimal fibrosis at baseline (n=421), and validated in an independent NAFLD cohort (n=78). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL17230
24 Samples
Download data: TXT
Series
Accession:
GSE85547
ID:
200085547
3.

Prognostic Liver Signature profiles in post-transplant liver biopsy tissues from chronic hepatitis C patients

(Submitter supplied) Background/Aims: There is a major unmet need to assess prognostic impact of anti-fibrotics in clinical trials due to the slow rate of liver fibrosis progression. We aimed to develop a surrogate biomarker to predict future fibrosis progression. Methods: A Fibrosis Progression Signature (FPS) was defined to predict fibrosis progression within 5 years in HCV and NAFLD patients with no to minimal fibrosis at baseline (n=421), and validated in an independent NAFLD cohort (n=78). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL17230
38 Samples
Download data: TXT
Series
Accession:
GSE85546
ID:
200085546
4.

A cell-based model unravels drivers for hepatocarcinogenesis and targets for clinical chemoprevention

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Rattus norvegicus; Homo sapiens; Hepacivirus hominis
Type:
Expression profiling by array; Expression profiling by high throughput sequencing
7 related Platforms
265 Samples
Download data
Series
Accession:
GSE66843
ID:
200066843
5.

Gene expression profiles of Huh7.5.1 and HepG2 cells infected with HCV, HBV, HDV, and alcohol, and clinical liver tissues treated with various compounds of co-culture with LX2 cells

(Submitter supplied) Hepatocellular carcinoma (HCC) is the second leading cause of cancer death. Curative approaches are limited and chemoprevention is not available. A 186-gene signature in liver tissue predicts HCC risk in cirrhotic patients of various etiologies. However, the drivers of the HCC risk gene signature remain to be fully elucidated. Here, we develop a simple and robust liver cell-based system in which persistent hepatitis B and C virus infection or ethanol exposure induce this signature. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL19886 GPL17230
95 Samples
Download data: TXT
Series
Accession:
GSE66841
ID:
200066841
6.

A genomic and clinical prognostic index for hepatitis C-related early-stage cirrhosis that predicts clinical deterioration

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL14951 GPL17230
244 Samples
Download data
Series
Accession:
GSE54102
ID:
200054102
7.

Expression profiles of 186-gene signature in U.S. hepatitis C virus (HCV)-related liver cirrhosis

(Submitter supplied) OBJECTIVE: The number of patients with HCV-related cirrhosis is increasing, leading to a rising risk of complications and death. Prognostic stratification in patients with early-stage cirrhosis is still challenging. We aimed to develop and validate a clinically useful prognostic index based on genomic and clinical variables to identify patients at high risk of disease progression. DESIGN: We developed a prognostic index, comprised of a 186-gene signature validated in our previous genome-wide profiling study, bilirubin (>1 mg/dL) and platelet count (<100 000/mm3), in an Italian HCV cirrhosis cohort (training cohort, n=216, median follow-up 10 years). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL17230
145 Samples
Download data: TXT
Series
Accession:
GSE54100
ID:
200054100
8.

Expression profiles of 186-gene signature in Italian hepatitis C virus (HCV)-related liver cirrhosis

(Submitter supplied) OBJECTIVE: The number of patients with HCV-related cirrhosis is increasing, leading to a rising risk of complications and death. Prognostic stratification in patients with early-stage cirrhosis is still challenging. We aimed to develop and validate a clinically useful prognostic index based on genomic and clinical variables to identify patients at high risk of disease progression. DESIGN: We developed a prognostic index, comprised of a 186-gene signature validated in our previous genome-wide profiling study, bilirubin (>1 mg/dL) and platelet count (<100 000/mm3), in an Italian HCV cirrhosis cohort (training cohort, n=216, median follow-up 10 years). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL17230
90 Samples
Download data: TXT
Series
Accession:
GSE54099
ID:
200054099
9.

Gene-expression profiles of archived section of formalin-fixed paraffin-embedded (AS-FFPE) liver and tumor tissues from hepatocellular carcinoma patients (Illumina and Nanostring)

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL17230 GPL13369
160 Samples
Download data
Series
Accession:
GSE47595
ID:
200047595
10.

Gene-expression profiles of archived section of formalin-fixed paraffin-embedded (AS-FFPE) liver tissues from hepatocellular carcinoma patients

(Submitter supplied) Background and Aims Formalin-fixed, paraffin-embedded (FFPE) tissue is the most commonly available form of archived clinical specimens, which are often stored as thin sections on glass slides. RNA isolated from such archived section (AS) of FFPE tissue is more degraded compared to freshly cut (FC) FFPE section because of prolonged air exposure. In this study, we evaluated performance of transcriptome profiling-based disease classification in AS-FFPE tissue. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL17230
24 Samples
Download data: TXT
Series
Accession:
GSE47594
ID:
200047594
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