GEO DataSets

(Submitter supplied) Granulomas are the pathological hallmark of tuberculosis (TB). In individuals latently infected with Mycobacterium tuberculosis (M. tb), the bacteria are thought to reside within the granulomas in a nonreplicating dormant state due to the lack of oxygen and nutrients. However, a portion of these individuals will develop active TB and little is known on the bacterial mechanisms/factors involved in this process. more...

Organism:

Mycobacterium marinum

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21992

25 Samples

Download data: XLSX

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Danio rerio; Mycobacterium marinum

Type:

Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:

GPL21992 GPL24995

42 Samples

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(Submitter supplied) Granulomas are the pathological hallmark of tuberculosis (TB). In individuals latently infected with Mycobacterium tuberculosis (M. tb), the bacteria are thought to reside within the granulomas in a nonreplicating dormant state due to the lack of oxygen and nutrients. However, a portion of these individuals will develop active TB and little is known on the bacterial mechanisms/factors involved in this process. more...

Organism:

Mycobacterium marinum

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL21992

6 Samples

Download data: XLSX

(Submitter supplied) Granulomas are the pathological hallmark of tuberculosis (TB). In individuals latently infected with Mycobacterium tuberculosis (M. tb), the bacteria are thought to reside within the granulomas in a nonreplicating dormant state due to the lack of oxygen and nutrients. However, a portion of these individuals will develop active TB and little is known on the bacterial mechanisms/factors involved in this process. more...

Organism:

Mycobacterium marinum

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21992

30 Samples

Download data: XLSX

(Submitter supplied) Regulation of M. marinum gene expression in an espM deletion strain

Organism:

Mycobacterium marinum

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21992

12 Samples

Download data: XLSX

(Submitter supplied) Here, we report the discovery of a novel mechanism of genetic complementation in M. marinum. We found that nonsense suppression was causing genetic complementation. Nonsense suppression was linked to alterations in cell permeability and exposure to the aminoglycoside antibiotic, hygromycin.

Organism:

Mycobacterium marinum

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21992

6 Samples

Download data: XLSX

(Submitter supplied) WhiB6 is a transcription factor that regulates expression of genes encoding ESX-1 substrates. We found that in the absence of the genes encoding conserved membrane components of the ESX-1 system, the expression of the whiB6 gene and genes encoding ESX-1 substrates were reduced.

Organism:

Mycobacterium marinum

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21992

10 Samples

Download data: XLSX